A5100455961- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Lung Cancer Treatments and Mutations
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Nutrition and Health in Aging
- Aortic aneurysm repair treatments
- Oral health in cancer treatment
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Head and Neck Cancer Studies
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Hydrogen's biological and therapeutic effects
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Immunotherapy and Biomarkers
- Antiplatelet Therapy and Cardiovascular Diseases
- Photocathodes and Microchannel Plates
- High Altitude and Hypoxia
- Chronic Myeloid Leukemia Treatments
Peking University Third Hospital
2011-2024
Peking University
2009-2024
Chengdu University of Traditional Chinese Medicine
2024
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
Zaozhuang Municipal Hospital
2023
Shenzhen Third People’s Hospital
2023
United States Congress
2022
Kunming Medical University
2021
Qinghai Red Cross Hospital
2021
Effects of genistein on wild-type (wt) and delta F508-cystic fibrosis transmembrane conductance regulator (CFTR) were studied in NIH/3T3 cells stably transfected with wt or mutant CFTR cDNA. As measured by I- efflux, half-maximal concentration agonist (K1/2) for forskolin-dependent activation was greater F508-CFTR than wt-CFTR. Genistein decreased the K1/2 both forms channel increased maximal activity 3.7-fold. In cell-attached patches, 10 microM forskolin induced minimal characteristic...
Previous studies have shown that genistein increased cystic fibrosis transmembrane conductance regulator (CFTR) channel activity in the presence of saturating concentrations forskolin and calyculin A intact cells. Possible molecular mechanisms for genistein's action include inhibition tyrosine kinases, serine/threonine protein phosphatases, or direct binding to CFTR. Since inhibits several enzymes hydrolyze ATP, ATP hydrolysis is an intrinsic property CFTR, we examined effect on CFTR gating...
Gating of the cystic fibrosis transmembrane conductance regulator (CFTR) involves a coordinated action ATP on two nucleotide binding domains (NBD1 and NBD2). Previous studies using nonhydrolyzable analogues NBD mutant CFTR have suggested that hydrolysis at NBD1 is required for opening channel, while nucleotides NBD2 controls channel closing. We studied ATP-dependent gating in excised inside-out patches from stably transfected NIH3T3 cells. Single kinetics different [ATP] were analyzed. The...
Due to the reality gap between designed models and as‐built real‐world scenarios, improving accuracy of 3D power transmission lines is essential when transferring them from design department operation department. Point clouds obtained drone's remote sensing provide a credible reference for verification model. However, pylon localization using traditional point cloud segmentation methods limited due complex background as well noise in cloud. In this paper, we propose sequential pose method...
<i>Background:</i> Induced sputum analysis has been widely used to assay airway inflammation. However, the mucolytic agent dithiothreitol (DTT) may affect detection of some soluble mediators. <i>Objectives:</i> Our study was designed investigate whether DTT affects monocyte chemoattractant protein (MCP)-1, macrophage inflammatory (MIP)-1α and interleukin (IL)-10. <i>Methods:</i> Sputum samples were collected from 12 patients with chronic obstructive...
We conducted a focus group study in an urban hospital-based primary care teaching clinic serving indigent and Hispanic (predominantly Puerto Rican) population New England order to learn how patients with Chronic Obstructive Lung Disease (COPD) perceive their disease, they experience medical care, the barriers face managing disease following recommendations. The research team included doctors, nurses, anthropologist, clinical pharmacist, hospital interpreter, systems analyst. Four groups were...
Background: People with cystic fibrosis (CF) suffer from chronic lung disease that is often treated a bronchodilator. This trial evaluated the pharmacokinetics, safety, and tolerability of single multiple doses tiotropium inhaled via Respimat® Soft Mist™ Inhaler in patients CF. Methods: Patients received dose (placebo, 2.5 μg, 5 or 10 μg) and/or daily for 28 days. Results: Ninety-two patients, aged 5–57 years, were treated. All showed satisfactory safety profile adverse events, vital signs,...
Appropriate management of acute exacerbation chronic obstructive pulmonary disease (AECOPD) is very important because such negatively impacts patients' health status, progression, and mortality. Exacerbation episodes are mainly triggered by viral bacterial infections, one study showed that 55% hospitalized patients with AECOPD had a infection.[1] Some analyses have suggested antibiotic therapy can reduce the risk short-term mortality improve prognosis. However, not all benefit from therapy....
<title>Abstract</title> <italic>Background:</italic> Substantial evidence links PM2.5 to the development of inflammatory lung diseases such as chronic airways, but effective treatments are lacking. Gan-Du-Qing Decoction is a traditional Chinese medicine formula for airway inflammation. However, whether GDQ can ameliorate PM2.5-induced injury and its mechanism unknown we will further investigate.. <italic>Study Design/Methods:</italic> Male Sprague-Dawley (SD) rats weighing 120 grams were...
Aim: To develop and validate a simple method using UPLC-MS/MS for determination of apatinib its three active metabolites in Phase IV clinical trial. Materials & methods: All compounds were separated on Hypersil GOLD™ aQ C18 Polar Endcapped LC column (50 × 2.1 mm, 1.9 μm, Thermo) 5 mmol/l ammonium acetate with 0.1% formic acid:acetonitrile (20:80, v/v) as the mobile phase after rapid liquid-liquid extraction. This was validated over linear concentration range 1.00-1000 ng/ml each compound....
There is no optimal treatment to alleviate the decline of lung function in stable phase chronic obstructive pulmonary disease (COPD). The effectiveness moxibustion as an adjunctive for COPD has been reported clinically, but conclusions on efficacy and safety have not unified. This study will systematically evaluate phase, providing clinical-based evidence.We search 7 literature databases 2 clinical trial registration platforms. searching time be conducted from establishment March 31, 2021,...
Objective To analyze the influences of stress relief intervention on level and emotion patients with chronic hepatitis B (CHB). Methods A total 102 CHB in First Affiliated Hospital Harbin Medical University were selected divided into control group (with 53 cases conventional nursing) observation 49 intervened by relief). Stress anxious from both groups before after compared. Results After intervention, score was (21.04±6.03), lower than that (30.66±7.46); anxiety (42.18±3.70),...
Objective To examine the levels of fractional exhaled nitric oxide in bronchial asthma and correlation between pulmonary function tests as well value curing children with asthma. Methods Seventy-two asthmatic came from Guiyang Maternal Child Health Hospital were studied.They divided into 2 groups: mild-to-moderate group (36 cases) serious cases). Fractional level lung measured analysis was analyzed by SPSS 13.0 software. Results The concentration significantly higher than that...
Objective To explore the influencing factors of treatment compliance and nursing strategy in traumatic epilepsy patients. Methods The compliance, effectiveness 64 patients from July 2012 to June 2013 were investigated by self-designed questionnaires, then put forward strategy. Results The was only 56.3%, improved with increasing differences statistically significant (χ2=10.100, P<0.05). Compliance influenced anxiety, drug side-effects, disease knowledge low...
Background Anticoagulation is an important clinical issue.At present,the new oral anticoagulants (NOACs)are increasingly replacing traditional in practice.Advantages of these agents include their rapid onset and elimination,predictable anticoagulant effect no need for routine monitoring.Objective To report the recent progress NOACs applied perioperative period.Content summarize current literature on NOACs' pharmacology application,especially period operation.Trend If possible,the should be...