A5029740848- Chemical Safety and Risk Management
- Risk and Safety Analysis
- Occupational Health and Safety Research
- Analytical Chemistry and Sensors
- Polymer Surface Interaction Studies
- Genetic Neurodegenerative Diseases
- Force Microscopy Techniques and Applications
- biodegradable polymer synthesis and properties
- Mechanical and Optical Resonators
- Molecular Junctions and Nanostructures
- Gold and Silver Nanoparticles Synthesis and Applications
- Neuroscience and Neuropharmacology Research
- Advanced Fluorescence Microscopy Techniques
- Fungal and yeast genetics research
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Parkinson's Disease Mechanisms and Treatments
- Technology Assessment and Management
- Lipid Membrane Structure and Behavior
- Material Properties and Applications
- Chemistry and Chemical Engineering
- Photonic and Optical Devices
- Advanced MEMS and NEMS Technologies
- Hydrogels: synthesis, properties, applications
- Mitochondrial Function and Pathology
Institute for Environmental Management
2024
American Chemical Society
2020-2021
University of Illinois Urbana-Champaign
2013-2020
Myotonic dystrophy type 1 (DM1) is caused by an expanded CUG repeat (CUG(exp)) that sequesters muscleblind-like protein (MBNL1), a regulates alternative splicing. CUG(exp) RNA validated drug target for this currently untreatable disease. Herein, we develop bioactive small molecule (1) targets and able to inhibit the CUG(exp)·MBNL1 interaction in cells model DM1. The core of based on ligand 2, which was previously reported be active vitro assay. A polyamine-derivative side chain conjugated...
We describe the 3-iodopropyl acetal moiety as a simple cleavable unit that undergoes acid catalyzed hydrolysis to liberate HI (pKa ∼ −10) and acrolein stoichiometrically. Integrating this into linear network polymers gives class of macromolecules undergo new mechanism degradation with an amplified, sigmoidal rate. This trigger-responsive self-amplified degradable polymer accelerated rate agent release.
An expanded CUG repeat transcript (CUG(exp)) is the causative agent of myotonic dystrophy type 1 (DM1) by sequestering muscleblind-like protein (MBNL1), a regulator alternative splicing. On basis ligand (1) that was previously reported to be active in an vitro assay, we present synthesis small library containing 10 dimeric ligands (4-13) differ length, composition, and attachment point linking chain. The oligoamino linkers gave greater gain affinity for RNA were more effective when compared...
We apply fast relaxation imaging (FReI) as a novel technique for investigating the folding stability and dynamics of proteins within polyacrylamide hydrogels, which have diverse widespread uses in biotechnology. FReI detects protein unfolding situ by changes fluorescence resonance energy transfer (FRET) after temperature jump perturbations. Unlike bulk measurements, diffraction-limited epifluorescence combined with perturbations reveals impact local environment effects on protein-biomaterial...
Vibrational resonances of microelectromechanical systems (MEMS) can serve as means for assessing physical properties ultrathin coatings in sensors and analytical platforms. Most such technologies exist largely two-dimensional configurations with a limited total number accessible vibration modes modal displacements, thereby placing constraints on design options operational capabilities. This study presents set concepts three-dimensional (3D) microscale platforms vibrational excited by...
The laboratory safety team (LST) movement was triggered in 2012 by Dow Chemical's exploration of ways to strengthen academic research culture from the bottom up. This necessitated a new form leadership graduate students and postdoctoral scholars. has been spreading throughout chemistry engineering departments United States grassroots fashion. However, few publications exist providing details LST structure activities. In this paper, we share results interviews with 16 currently active teams...
The widespread interest in neutral, water-soluble polymers such as poly(ethylene glycol) (PEG) and poly(zwitterions) poly(sulfobetaine) (pSB) for biomedical applications is due to their widely assumed low protein binding. Here we demonstrate that pSB chains solution can interact with proteins directly. Moreover, reduce the thermal stability increase folding cooperativity relative buffer or PEG solutions. Polymer-dependent changes tryptophan fluorescence spectra of three structurally-distinct...
Recurring academic laboratory accidents and a lack of consensus about the best approach to chemical safety culture education has led development team (LST) programs at many research institutions in United States. LSTs are collaborative groups that seek improve within department or multiple departments. They usually consist partnership between departmental faculty, staff, students have goal providing concrete opportunities for all these stakeholders continuously practices their department....
Nanoantenna-based surface-enhanced infrared absorption (SEIRA) is a powerful platform for the detection of biological and chemical species due to its ability strongly enhance relatively narrow band vibrational modes. However, SEIRA only detects molecules within order 100 nm nanoantenna, thus, it requires diffusion analyte into local vicinity nanoantenna provide enhanced sensing. Here, we demonstrate use polyacrylamide hydrogel film with imbedded radial gradient locally concentrate analytes...
Polymer brushes are found in biomedical and industrial technologies, where they exhibit functionalities considerably dependent on polymer brush-solvent-analyte interactions. It remains a difficult challenge to quickly analyze solvent-swollen brushes, both at the solvent-polymer brush interface interior, as well monitor kinetics of interaction with key analytes. Here, we demonstrate novel use silicon photonic microring resonators characterize situ swollen brush-analyte By monitoring resonant...
ADVERTISEMENT RETURN TO ISSUEEditorialNEXTImpact Factor: Friend or Foe?Mary Beth Mulcahy*Mary Mulcahy*E-mail: [email protected]More by Mary Mulcahyhttps://orcid.org/0000-0002-3060-9189, Kali A. MillerKali MillerMore Millerhttps://orcid.org/0000-0003-3632-0615, and Harry ElstonHarry ElstonMore Elstonhttps://orcid.org/0000-0003-4730-6421Cite this: ACS Chem. Health Saf. 2021, 28, 5, 291–292Publication Date (Web):September 27, 2021Publication History Published online27 September 2021Published...
Abstract Silicon photonic microring resonators have emerged as a promising technology for the sensitive detection of biological macromolecules, including proteins and nucleic acids. However, not all species interest are large biologics that can be targeted by highly specific capture agents. For smaller organic chemicals, many toxic regulated species, general approach to improving sensitivity would desirable. By functionalizing surface silicon with polymer brushes, small molecules selectively...
ADVERTISEMENT RETURN TO ISSUEEditorialNEXTCitation Bias in Organic Chemistry Research: Are Industry-Affiliated Papers Cited Less Often?Kai Rossen*Kai RossenSanofi, 65926 Frankfurt, Germany*Email: [email protected]More by Kai Rossenhttp://orcid.org/0000-0002-3857-0004 and Kali A. MillerKali MillerJournals Publishing Group, American Chemical Society, Washington, D.C. 20036, United StatesMore Millerhttp://orcid.org/0000-0003-3632-0615Cite this: Org. Process Res. Dev. 2021, 25, 2,...
To optimize the technical, economic, and social benefits of chemical enterprise, practice chemistry must consider address best safety practices from concept through research, development, manufacture, use, disposal its products. Only such a holistic approach will control individual public risks associated with resulting technologies to acceptable levels. For this reason, in 2016, ACS Board Directors adopted as one Society's core values. This action established expectation that Society...