A5054931429- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Intramuscular injections and effects
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Cancer therapeutics and mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Chemotherapy-related skin toxicity
- Probiotics and Fermented Foods
- COVID-19 Clinical Research Studies
- Eosinophilic Disorders and Syndromes
Exact Sciences (United States)
2019
Topical use of antibacterial drugs as part complex therapy for purulent-inflammatory infections the skin and oropharynx can not only eliminate symptoms but also influence cause disease. Dioxidine® is a broad-spectrum drug, active against both gram-positive gram-negative bacteria. The aim this study was to investigate bioavailability, pharmacokinetic parameters, safety profile Dioxidine®, solution topical external use, 0.25 mg/ml, in cutaneous application. Another dosage form — infusion 5...
AIM. To measure the trough and maximum plasma concentrations of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML) patients on standard reduced doses drugs, to evaluate impact TKI concentration loss major/deep molecular response (MR) after dose reduction drug toxicity changes. MATERIALS & METHODS. The trial enrolled 46 imatinib 16 nilotinib recipients. (Сtrough) (Cmax) were measured. On imatinib/nilotinib therapy, Ctrough was analyzed 104/22 Cmax 63/15 samples,...
Aim . To assess the effect of rifaximin and a multi-strain probiotic on intestinal microbiome indicators cardiovascular risk in patients with coronary heart disease (CHD). Materials methods. A study conducted during 2016–2019 period included 120 people over 50 years old divided into 3 groups. Group 1 comprised receiving standard treatment. 2 additionally (Bifidobacterium bifidum no less than 1x109 CFU; Bifidobacterium longum infantis Lactobacillus rhamnosus CFU) within 28 days. CHD for 7...
Molnupiravir is one of the drugs for etiotropic therapy a new coronavirus infection COVID-19. It has confirmed its clinical efficacy in treatment patients with mild and moderate COVID-19, including those who are at high risk progressing to severe disease. The aim study was evaluate bioequivalence generic drug molnupiravir ALARIO-TL original Lagevrio single oral administration healthy volunteers. Materials methods. This an open, randomized, two-period crossover study. In each two periods,...
Nirmatrelvir is an antiviral drug that, in combination with ritonavir, effective agent for the etiotropic therapy of patients mild to moderate COVID-19. The aim study was evaluate bioequivalence generic nirmatrelvir Аrpaxel ritonavir and original Paxlovid, which a nirmatrelvir/ritonavir, single dose administration healthy volunteers. Materials methods. This research open-label, randomized, two-period crossover study. It included 2 periods, each volunteers received either test (nirmatrelvir...