A5084545534- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Spaceflight effects on biology
- Medical and Biological Ozone Research
Cardiff University
2016-2017
Purpose: To investigate the effect of various riboflavin/ultraviolet light (UVA) crosslinking (CXL) protocols on corneal enzymatic resistance. Methods: A total 66 enucleated porcine eyes, with epithelium removed, were divided into 6 groups. Group 1 remained untreated. Groups 2 to received riboflavin/dextran for 30 minutes. 3 underwent standard CXL (SCXL) mW/cm2 UVA minutes (total energy dose 5.4 J/cm2). 4 and 5 high intensity (HCXL) using (5.4 J/cm2) (7.2 J/cm2), respectively. was exposed 8...
The application of inhibitors the Rho kinase pathway (ROCK inhibitors) to surface eye in form eyedrops has beneficial effects which aid recovery diseased or injured endothelial cells that line inner cornea. aim this study was test plausibility delivering a selective ROCK inhibitor, Y-27632, cornea using thin polymeric film. Mucoadhesive films were prepared incorporating Y-27632 and diffusional release into PBS determined. Topical ocular delivery from applied film investigated freshly excised...
Purpose . To examine the effects of transcorneal freezing using a new cryoprobe designed for corneal endothelial surgery. Methods A console employing nitrous oxide as cryogen was used to cool series different tip designs made silver high thermal conductivity. In vitro studies were conducted on 426 porcine corneas, followed by preliminary in vivo investigations three rabbit corneas. Results The epithelium destroyed freezing, expected; however, epithelial basement membrane remained intact....