A5016544434- Soft Robotics and Applications
- Biochemical and Molecular Research
- Modular Robots and Swarm Intelligence
- Protein Tyrosine Phosphatases
- Industrial Vision Systems and Defect Detection
- PI3K/AKT/mTOR signaling in cancer
- Scientific Computing and Data Management
- Robotics and Sensor-Based Localization
- Protein Kinase Regulation and GTPase Signaling
- Systems Engineering Methodologies and Applications
- Lung Cancer Treatments and Mutations
- Advanced Vision and Imaging
- Chronic Lymphocytic Leukemia Research
- Advanced Sensor and Energy Harvesting Materials
- Ethics and Social Impacts of AI
- Melanoma and MAPK Pathways
- Robot Manipulation and Learning
- Bioactive Compounds and Antitumor Agents
- Dementia and Cognitive Impairment Research
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Food Supply Chain Traceability
- Cancer Genomics and Diagnostics
- Hate Speech and Cyberbullying Detection
- Advanced Breast Cancer Therapies
Commonwealth Scientific and Industrial Research Organisation
2022-2024
Pfizer (United States)
2023
Loxo Oncology at Lilly (United States)
2023
Data61
2022
Array BioPharma (United States)
2015-2020
Capping off an era marred by drug development failures and punctuated waning interest presumed intractability toward direct targeting of KRAS, new technologies strategies are aiding in the target's resurgence. As previously reported, tetrahydropyridopyrimidines were identified as irreversible covalent inhibitors KRASG12C that bind switch-II pocket KRAS make a bond to cysteine 12. Using structure-based design conjunction with focused vitro absorption, distribution, metabolism excretion...
Heterogeneous teams of robots, leveraging a balance between autonomy and human interaction, bring powerful capabilities to the problem exploring dangerous, unstructured subterranean environments. Here we describe solution developed by Team CSIRO Data61, consisting CSIRO, Emesent Georgia Tech, during DARPA Subterranean Challenge. These presented systems were fielded in Tunnel Circuit August 2019, Urban February 2020, our own Cave event, conducted September 2020. A unique capability team is...
Bruton tyrosine kinase (BTK), a nonreceptor kinase, is major therapeutic target for B-cell driven malignancies. However, approved covalent BTK inhibitors (cBTKi) are associated with treatment limitations due to off-target side effects, suboptimal oral pharmacology, and development of resistance mutations (eg, C481) that prevent inhibitor binding. Here we describe the preclinical profile pirtobrutinib, potent, highly selective, non-covalent (reversible) inhibitor. Pirtobrutinib binds an...
KRAS is the most frequently mutated driver oncogene in human cancer, and mutations are commonly associated with poor prognosis resistance to standard treatment. The ability effectively target block function of has remained elusive despite decades research. Recent findings have demonstrated that directly targeting KRAS-G12C electrophilic small molecules covalently modify codon 12 cysteine feasible. We discovered a series tetrahydropyridopyrimidines as irreversible covalent inhibitors vivo...
The DARPA Subterranean Challenge was designed for competitors to develop and deploy teams of autonomous robots explore difficult unknown underground environments. Categorized in human-made tunnels, urban infrastructure, natural caves, each these subdomains had many challenging elements robot perception, locomotion, navigation, autonomy. These included degraded wireless communication, poor visibility due smoke, narrow passages doorways, clutter, uneven ground, slippery loose terrain, stairs,...
SHP2 has emerged as an important target for oncology small-molecule drug discovery. As a nonreceptor tyrosine phosphatase within the MAPK pathway, it been shown to control cell growth, differentiation, and oncogenic transformation. We used structure-based design find novel class of potent orally bioavailable inhibitors. Our efforts led discovery 5-azaquinoxaline new core developing this compounds. Optimization potency properties scaffold generated compound 30, that exhibited in vitro...
Fibre jamming is a new and understudied soft robotic mechanism that has previously found success in stiffness-tunable arms fingers. However, to date researchers have not fully taken advantage of the freedom offered by contemporary fabrication techniques including multi-material 3D printing creation fibre structures. In this research, we present novel, modular, multi-material, printed, tendon unit for use compliant ankle, or Jammkle. Its multimaterial printed design offers unparalleled...
Abstract Background: Activating mutations and oncogenic fusions of the RET receptor tyrosine kinase have been identified in multiple tumor types, including thyroid, lung, breast colon carcinoma. Furthermore, inhibitors (TKIs) with anti-RET activity produced clinical responses patients whose tumors harbor alterations. However, currently available were initially developed to target kinases other than are only moderately potent against RET, inhibit or poorly secondary resistance (e.g....
Abstract Covalent Bruton tyrosine kinase inhibitors (cBTKi) have transformed the treatment of B cell malignancies. Despite efficacy cBTKi, failure often occurs through development resistance or intolerance. Pirtobrutinib, a highly selective, non-covalent BTKi, potently inhibits both WT and C481 mutant BTK. Pirtobrutinib has favorable oral pharmacology, is well tolerated, shown promising in patients with poor prognosis malignancies following prior therapy, including cBTKi. Here we report...
The DARPA Subterranean Challenge was designed for competitors to develop and deploy teams of autonomous robots explore difficult unknown underground environments. Categorised in human-made tunnels, urban infrastructure natural caves, each these subdomains had many challenging elements robot perception, locomotion, navigation autonomy. These included degraded wireless communication, poor visibility due smoke, narrow passages doorways, clutter, uneven ground, slippery loose terrain, stairs,...
Humans possess a remarkable ability to react unpredictable perturbations through immediate mechanical responses, which harness the visco-elastic properties of muscles maintain balance. Inspired by this behaviour, we propose novel design robotic leg utilising fibre jammed structures as passive compliant mechanisms achieve variable joint stiffness and damping. We developed multi-material tendons with tunable properties, can be 3D printed in one-go without need for assembly. Through extensive...
Fibre jamming is a relatively new and understudied soft robotic mechanism that has previously found success when used in stiffness-tuneable arms fingers. However, to date researchers have not fully taken advantage of the freedom offered by contemporary fabrication techniques including multi-material 3D printing creation fibre structures. In this research, we present novel, modular, multi-material, printed, tendon unit for use compliant ankle, or Jammkle. We describe design Jammkle highlight...