Rasmus Amund Henriksen
A5006605808- Forensic and Genetic Research
- Cancer Genomics and Diagnostics
- Genetic diversity and population structure
- Genomics and Chromatin Dynamics
- Genomics and Phylogenetic Studies
- Yersinia bacterium, plague, ectoparasites research
- DNA Repair Mechanisms
- Digestive system and related health
- Renal and related cancers
- Race, Genetics, and Society
- Epigenetics and DNA Methylation
- Linguistics and language evolution
- Microbial Community Ecology and Physiology
- Wildlife Ecology and Conservation
- Linguistics and Cultural Studies
- Archaeology and ancient environmental studies
- Methane Hydrates and Related Phenomena
- Indigenous Studies and Ecology
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Molecular Biology Techniques and Applications
- Species Distribution and Climate Change
- Climate change and permafrost
- Historical and Archaeological Studies
Lundbeck Foundation
2022-2024
University of Copenhagen
2020-2024
Globe University
2024
Abstract Western Eurasia witnessed several large-scale human migrations during the Holocene 1–5 . Here, to investigate cross-continental effects of these migrations, we shotgun-sequenced 317 genomes—mainly from Mesolithic and Neolithic periods—from across northern western Eurasia. These were imputed alongside published data obtain diploid genotypes more than 1,600 ancient humans. Our analyses revealed a ‘great divide’ genomic boundary extending Black Sea Baltic. hunter-gatherers highly...
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for dietary, physical and mental health present-day populations. Using a dataset more than 1,600 imputed ancient genomes
Abstract Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales 1–4 . However, insights into the population dynamics contact zones are hampered by a lack of ancient genomic data sampled high spatiotemporal resolution 5–7 Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years Mesolithic period, Neolithic period and Early Bronze Age Denmark integrated these with proxies for diet ( 13 C 15 N content),...
Summary Western Eurasia witnessed several large-scale human migrations during the Holocene 1–5 . To investigate cross-continental impacts we shotgun-sequenced 317 primarily Mesolithic and Neolithic genomes from across Northern Eurasia. These were imputed alongside published data to obtain diploid genotypes >1,600 ancient humans. Our analyses revealed a ‘Great Divide’ genomic boundary extending Black Sea Baltic. hunter-gatherers (HGs) highly genetically differentiated east west of this...
Circular DNA can arise from all parts of eukaryotic chromosomes. In yeast, circular ribosomal (rDNA) accumulates dramatically as cells age, however little is known about the accumulation other chromosome-derived circles or contribution such to genetic variation in aged cells. We profiled Saccharomyces cerevisiae populations sampled when young and after extensive aging. Young possessed highly diverse but 94% were lost ∼15 divisions, whereas rDNA underwent massive >95% DNA. Circles present...
Abstract Summary With the rapid expansion of capabilities DNA sequencers throughout different sequencing generations, quantity generated data has likewise increased. This evolution also led to new bioinformatical methods, for which in silico have become crucial when verifying accuracy a model or robustness genomic analysis pipeline. Here, we present multithreaded next-generation simulator (NGSNGS), simulates reads faster than currently available methods and programs. NGSNGS can simulate with...
Summary Using ancient environmental DNA (eDNA) 1 we reconstructed microbial and viral communities from the Kap København Formation in North Greenland 2 . We find pioneer communities, along with likely dormant methanogens permafrost’s seed bank. Our findings reveal that at time of formation, terrestrial input site originated a palustrine wetland, suggesting non-permafrost conditions. During this time, detection methanogenic archaea carbon processing pathways suggests moderate strengthening...
Summary The Eurasian Holocene (beginning c. 12 thousand years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for dietary, physical and mental health present-day populations. Using an imputed dataset >1600 complete ancient genome sequences, new computational methods locating selection time space, we reconstructed landscape transition from hunting gathering, to farming pastoralism across West Eurasia. We identify major signals...
Summary Today, Germanic languages, including German, English, Frisian, Dutch and the Nordic are widely spoken in northwest Europe. However, key aspects of assumed arrival diversification this linguistic group remain contentious 1–3 . By adding 712 new ancient human genomes we find an archaeologically elusive population entering Sweden from Baltic region by around 4000 BP. This became widespread throughout Scandinavia 3500 BP, matching contemporaneous distribution Palaeo-Germanic, Bronze Age...
Motivation: One essential initial step in the analysis of ancient DNA is to authenticate that sequencing reads actually are from DNA. This done by assessing if exhibit typical characteristics postmortem damage, including cytosine deamination and nicks. We present a novel statistical method implemented fast multithreaded program, ngsBriggs, enables rapid quantification PMD estimation Briggs damage model parameters (Briggs parameters). Results: Using multinomial with maximum likelihood fit,...
Abstract Specimen-based taxonomic research is essential for understanding diversity and setting management frameworks threatened mammal faunas, ancient DNA techniques are increasingly used to extract information from taxonomically relevant historical specimens. The largest survivors of the depleted Caribbean fauna hutias in genus Capromys, which usually interpreted as containing a single species, C. pilorides. Previous studies have demonstrated genetic differentiation Capromys populations...
ABSTRACT One essential initial step in the analysis of ancient DNA is to authenticate that sequencing reads are actually from DNA. This done by assessing if exhibit typical characteristics post‐mortem damage (PMD), including cytosine deamination and nicks. We present a novel statistical method implemented fast multithreaded programme, ngsBriggs enables rapid quantification PMD estimation Briggs model parameters (Briggs parameters). Using multinomial with maximum likelihood fit, accurately...
Circular DNA of chromosomal origin form from all parts eukaryotic genomes. In yeast, circular rDNA accumulates as cells divide, contributing to replicative aging. However, little is known about how other chromosome-deri ved circles segregate and contribute geneticvariation age. We identified across the genome young S. cerevisiae populations their aged descendants. Young had highly diverse populations, but lost 94% different after 20 divisions. Circles present in both old were characterized...
Abstract Cell free extrachromosomal circular DNA (eccDNA) is evolving as a potential biomarker in liquid biopsies for disease diagnosis. In this study, an optimized next generation sequencing-based Circle-Seq method was developed to investigate urinary cell eccDNA (ucf-eccDNA) from 28 adult healthy volunteers (mean age = 28, 19 males/ 9 females). The genomic distributions and sequence compositions of ucf-eccDNAs were comprehensively characterized. Approximately 1.2 million unique are...