A5085849066- Plant Virus Research Studies
- Gastric Cancer Management and Outcomes
- HIV Research and Treatment
- Neuroscience and Neuropharmacology Research
- Gastrointestinal Tumor Research and Treatment
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- HIV/AIDS Research and Interventions
- Metastasis and carcinoma case studies
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic and Hepatic Oncology Research
- Memory and Neural Mechanisms
- Colorectal Cancer Surgical Treatments
- Neuroendocrine regulation and behavior
- Esophageal and GI Pathology
- Regulation of Appetite and Obesity
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Plant and Fungal Interactions Research
- Biochemical Analysis and Sensing Techniques
- T-cell and Retrovirus Studies
- Liver Disease Diagnosis and Treatment
National Institute of Infectious Diseases
2013-2025
International University of Health and Welfare
2019-2025
Kumamoto University
2022
Institute of Fruit Tree and Tea Science
2021
Asia University
2021
Toyota Technological Institute
2019
Azumi Hospital
2015-2018
National Agriculture and Food Research Organization
1991-2016
National Cancer Centre Japan
2014-2016
Institute of Vegetable and Floriculture Science
2016
We examined genetically determined oxidation polymorphisms of metoprolol and mephenytoin in 200 unrelated, healthy Japanese subjects 98 mainland Chinese simultaneously. This examination was done according to the respective reported phenotyping criteria by use urinary metablic ratio percentage excretion 4-hydroxymephenytoin 8 hours after dose administration. The frequencies occurrence poor metabolizers (PMs) versus were 0.5% 0% for 22.5% 17.4% mephenytoin, respectively. There no statistically...
ASEAN realized the Economic Community (AEC) at end of 2015. The AEC is an economic integration whose goals are free movement goods, services, investment, and skilled workers, freer capital. Following establishment Free Trade Area (AFTA), deepened its through AEC. Evaluations ASEAN's mixed. While highly praised for steady progress, there also assessments suggesting little progress in integration. This study examines AEC's evaluates integration, including AFTA. "FTA-plus" target level market...
A considerable number of gastric cancers derive from stomach mucosa where chronic atrophic gastritis is severe and extensive. Based on the fact that serum pepsinogen levels provide a precise measure extent gastritis, we have devised mass screening method involving measurement to identify subjects at high risk cancer. In 1991, screened 4,647 workers (male: 4,113, female: 534, mean age: 49.0 years) Japanese company using this method. Out 875 (18.8%) with I level less than 50 μg/liter I/II...
The effectiveness of comprehensive stroke center (CSC) capabilities on mortality remains uncertain. We performed a nationwide study to examine whether CSC influenced in-hospital patients with ischemic and hemorrhagic stroke.Of the 1,369 certified training institutions in Japan, 749 hospitals responded questionnaire survey regarding that queried availability personnel, diagnostic techniques, specific expertise, infrastructure, educational components recommended for CSCs. Among responded, data...
ABSTRACT Transfusion-transmissible infections among 808 blood donors in Ghana were investigated 1999. Antibody seroprevalences of 3.8, 0.7, 8.4, and 13.5%, respectively, for human immunodeficiency virus, T-cell lymphotrophic virus type 1, hepatitis C (HCV), Treponema pallidum obtained. The seroprevalence HCV infection was confirmed to be 0.9% after supplementary testing, the transfusion risk potential these pathogens demonstrated.
Erysipelothrix rhusiopathiae is a gram-positive rod capable of causing erysipelas in swine. To establish method for specifically detecting E. practical applications, such as the inspection slaughterhouses, feasibility using primers derived from DNA sequence coding 16S rRNA PCR-specific detection system was investigated. Oligonucleotide were designed to amplify 407-bp fragment by PCR. The amplification specific but not that other bacterial genera tested. This PCR-based efficiently and...
Cholinergic stimulation of the lateral hypothalamic neurons with intrahypothalamic microinjections acetylcholine or carbachol caused a marked increase in content active form glycogen (starch) synthase liver. Total activity enzyme (active plus inactive forms) was not increased significantly. The lowest effective dose 5 × 10 -10 mole, and optimum -9 mole. Similar applications other neurotransmitters, such as norepinephrine, dopamine, serotonin, γ-aminobutyric acid, did affect enzyme's activity.
The effects of electrical and chemical stimulations the hypothalamus on plasma levels glucagon, insulin, glucose were studied in undisturbed free-moving rabbits. Electrical stimulation ventromedial hypothalamic nucleus (VMH) caused a marked increase circulating level glucagon coincident with rapid rise level. insulin did not during VMH stimulation, but increased after cessation stimulation. lateral (LHN), other hand, alter either hormone. Microinjection minute amount acetylcholine into led...
Abstract Acute gastroenteritis associated with diarrhea is considered a serious disease in Africa and South Asia. In this study, we examined the trends causative pathogens of corresponding gut microbiota Ghana using microbiome analysis performed on diarrheic stools via 16S rRNA sequencing. total, 80 patients 34 healthy adults as controls, from 2017 to 2018, were enrolled study. Among diarrhea, 39 norovirus-positive 18 rotavirus-positive. The species richness (Chao1) was lower than that...
The effects of electrolytic lesions the suprachiasmatic nucleus (SCN) and ventromedial (VMH) hypothalamus on circadian rhythm liver glycogen metabolism were studied in rats fed during dark period (2000-0800 h). Bilateral SCN did not affect appreciably rhythmicity three parameters metabolism, i.e., content synthetase I phosphorylase a activities. In contrast, bilateral VMH resulted almost complete loss activity by lowering high normally observed late evening. also reduced amplitudes rhythms...
The ontogenesis of hypothalamic GH-releasing factor (GRF) in pre- and postnatal rats was examined by means a specific rat GRF RIA. Whereas content undetectable (less than 10 pg/hypothalamus) on day 17 gestation, it increased to 30-65 pg/hypothalamus during days 18-20. During life, more rapidly 20-50 0-20 or 50-90. 900-1300 50- 90-day-old rats, there no consistent sex difference life. Hypothalamic somatostatin levels, as measured RIA, showed developmental pattern similar that GRF....
Background Buruli ulcer (BU) caused by Mycobacterium ulcerans (M. ulcerans) has emerged as an important public health problem in several rural communities sub-Saharan Africa. Early diagnosis and prompt treatment are preventing disfiguring complications associated with late stages of the disease progression. Presently there is no simple rapid test that appropriate for early use low-resource settings where M. most prevalent. Methodology We compared conventional pocket warmer loop mediated...
HIV-1 infected individuals under antiretroviral therapy can control viremia but often develop non-AIDS diseases such as cardiovascular and metabolic disorders. Gut microbiome dysbiosis has been indicated to be associated with progression of these diseases. Analyses gut/fecal in individual regions are important for our understanding pathogenesis infections. However, data on not yet accumulated West Africa. In the present study, we examined fecal compositions adults Ghana, where approximately...
Diarrheal disease remains a major global health problem particularly in children under 5 years and the emergence of antibiotic-resistant strains causative pathogens could slow control efforts, settings where treatment options are limited. This surveillance study conducted Ghana aimed to determine prevalence antimicrobial susceptibility profile diarrhea-causing bacteria. was cross-sectional carried out five facilities Ga West Municipality between 2017 2021. Diarrheic stool samples from...
Human T-cell leukemia virus type 1 (HTLV-1) induces chronic long-term latent infection that can cause fatal diseases, including adult leukemia. HTLV-1 production is poor and undetectable during the asymptomatic phase of infection. Virus-host immune interaction in has not been fully determined. In present study, virus-specific antibody responses carriers (n = 77) were investigated. Neutralizing significantly higher individuals with anti-Env SU (gp46) levels positively correlated proviral...
Non-small-cell-lung cancer (NSCLC) medication use and guideline adherence remain unclear. We investigated treatment patterns among Japanese patients with NSCLC. analyzed by age histology in ≥ 20-year-olds stage IV NSCLC treated between 2016-2018 using diagnostic procedure combination data. Logistic regression analysis evaluated the impact of various factors on adherence. included 9,722 patients. In < 75-year-olds nonsquamous NSCLC, first-to third-line treatments comprised 31.8% platinum...
Abstract: To extrapolate the function of leptomeninges, we examined profile proteins secreted from cultured leptomeningeal cells prepared 1–2‐day‐old rats. In sodium dodecyl sulfate‐polyacrylamide gel electrophoresis analysis medium conditioned with cells, 20–25 differentially distinctive protein bands were noted. Through several chromatographic procedures (Sephadex G‐75, Mono Q, and 7C 8 ‐300), altogether 18 purified to homogeneity, partial amino acid sequence each was determined. Homology...