A5088630557- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Infectious Diseases and Tuberculosis
- Diagnosis and treatment of tuberculosis
- Viral Infections and Vectors
- Vibrio bacteria research studies
- Zoonotic diseases and public health
- Infectious Diseases and Mycology
- Food Safety and Hygiene
- Probiotics and Fermented Foods
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Milk Quality and Mastitis in Dairy Cows
- Salmonella and Campylobacter epidemiology
- Malaria Research and Control
- Viral Infections and Outbreaks Research
- Energy and Environment Impacts
- Escherichia coli research studies
- African Botany and Ecology Studies
- Parasites and Host Interactions
- Antibiotic Resistance in Bacteria
- Identification and Quantification in Food
University of Ghana
2014-2025
Noguchi Memorial Institute for Medical Research
2016-2025
Kwame Nkrumah University of Science and Technology
2024
Roosevelt Hospital
2022
University of Nottingham
2021
Urinary tract infection (UTI) is frequently encountered during pregnancy and associated with adverse maternal, fetal, neonatal effects. However, very little information available on the prevalence of UTI among pregnant women in northern part Ghana, a region high birth rate. This study employed cross-sectional analysis prevalence, antimicrobial profile, risk factors 560 attending primary care for antenatal check-ups. Sociodemographic obstetrical history personal hygiene were obtained using...
Summary Objectives To investigate the microbiological quality and presence of antibiotic residues in raw cow milk some indigenous products produced marketed by informal sector coastal savannah zone Ghana. Methods Milk samples were aseptically collected from 224 kraals 26 purchased processors retailers. Total plate counts, total coliform counts Escherichia coli E. O157:H7 determined all 250 samples. also tested for residues. Results exceeded 10 5 CFU/ml 45.2% while coliforms 3 66.0% was...
Background Pro- and anti-inflammatory cytokines are important mediators of immunity associated with malaria disease outcomes. However, their role in the establishment asymptomatic infections, which may precede development clinical symptoms, is not as well-understood. Methods We determined association pro other immune effector molecules malaria. measured compared plasma levels pro-inflammatory including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin (IL)-6,...
Abstract Acute gastroenteritis associated with diarrhea is considered a serious disease in Africa and South Asia. In this study, we examined the trends causative pathogens of corresponding gut microbiota Ghana using microbiome analysis performed on diarrheic stools via 16S rRNA sequencing. total, 80 patients 34 healthy adults as controls, from 2017 to 2018, were enrolled study. Among diarrhea, 39 norovirus-positive 18 rotavirus-positive. The species richness (Chao1) was lower than that...
Livestock diseases are a major constraint to agricultural productivity, frequently causing significant livelihood losses for farmers, and negatively affecting public food safety security. Vaccines provide an effective profitable means controlling most infectious livestock diseases, but remain underutilized. This study sought assess the barriers determinants of vaccination utilization priority in Ghana.We conducted mixed-method involving quantitative survey with ruminant farmers (N = 350)...
Diarrheal disease remains a major global health problem particularly in children under 5 years and the emergence of antibiotic-resistant strains causative pathogens could slow control efforts, settings where treatment options are limited. This surveillance study conducted Ghana aimed to determine prevalence antimicrobial susceptibility profile diarrhea-causing bacteria. was cross-sectional carried out five facilities Ga West Municipality between 2017 2021. Diarrheic stool samples from...
Mycobacterium tuberculosis complex (MTBC) and Non-tuberculosis (NTM) infections differ clinically, making rapid identification drug susceptibility testing (DST) very critical for infection control therapy. This study aims to use World Health Organization (WHO) approved line probe assay (LPA) differentiate mycobacterial isolates obtained from (TB) prevalence survey in Ghana determine their resistance patterns.A retrospective was conducted whereby a total of 361 were differentiated patterns...
To assess the safety of retailed poultry using prevalence antibiotic resistance in Escherichia coli (E. coli), a dominant intestinal microflora.Two medium-scale farms and 8 well-known retail outlets within La-Nkwantanang Madina municipality Accra were purposively selected for sampling from January to March 2020. We randomly sampled raw chicken (n = 25) fecal matter 50). All samples immediately transported on ice laboratory analysis 12 hours after collection. Conventional culture techniques,...
Food from animal sources continues to be a significant food safety hazard. This study determined the microbial quality and of beef along value chains with case studies in Ashaiman Municipality Ghana. Raw samples were collected four slaughter slabs analyzed using standard microbiological methods determine prevalence specific pathogens, including Salmonella species, Listeria monocytogenes (L. monocytogenes), Brucella as well Toxoplasma gondii (T. gondii), Cyclospora cayetanensis (C....
• New survey data on trustworthiness and accountability in wood burner regulation. Results suggest strengthening regulatory pressures consumer compliance. support enhancing collaboration across health/environment public agencies. need to empower national level expert delegated agencies the UK.
Background Early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) are Mycobacterium tuberculosis (Mtb)–specific antigens that secreted by actively metabolising bacteria contribute to the virulence of bacteria. Their ability induce Treg Th2 responses, particularly during first two weeks treatment, has not been comprehensively examined date. The purpose this work was characterise Th1, responses rESAT-6-CFP10 fusion in TB patients before intensive phase treatment...
Abstract Introduction : Sustainable livestock production remains of central importance for attaining food security globally and securing the livelihoods a sizeable proportion people in developing countries. However, ineffective control diseases often reduces productivity, results animal mortalities, may contribute to antimicrobial resistance. This study sought assess management strategies employed by farmers priority diseases, utilization, performance veterinary services. Methods We...
There has been a long held belief that patients with drug-susceptible TB are non-infectious after two weeks of therapy. Recent microbiological and epidemiological evidence challenged this dogma, however, the nature Mtb-specific cellular immune response during period not adequately investigated. This knowledge could be exploited in development immunological biomarkers early treatment response. Cellular to four Mtb infection phase-dependent antigens, ESAT-6/CFP-10 fusion protein three DosR...
Bacteria pathogens constitute a significant proportion of diarrhoea-causing food contaminants. Transmission antibiotic resistant foodborne to humans is major threat safety, especially in developing countries where quality hygiene and sanitation facilities are lacking. Factors related use, hand have been associated with the spread infectious diseases as well bacteria. Proper handling ensures that not contaminated potential pathogenic This study assessed carriage bacteria factors.A...
Query fever, also known as Q is a zoonotic disease caused by Coxiella burnetii. It cause of abortion in livestock and presents febrile illness humans. A correlation between the incidence humans goats sheep farms has been reported countries such Netherlands Australia. In Ghana, occurrence fever both not fully explored. This study sought to determine seroprevalence Nkawkaw, Eastern Region Ghana. Sera obtained from 92 12 were tested using indirect multi-species ELISA for detection anti-Coxiella...
We report the frequency and associated factors of tuberculosis (TB) parasite coinfection from newly diagnosed pulmonary TB patients (TB+) non-TB participants (TB−) Regional Tuberculosis Control Center, households, health facilities in Bobo-Dioulasso 2019 to 2021. Biological samples were examined for infection using direct microscopy, concentration techniques, immunochromatographic rapid test. Data analyzed STATA 14. Of a total 192 involved, 95 TB+ 97 non-TB. There was no statistically...
Rift Valley fever (RVF) is a re-emerging zoonotic disease of domestic ruminants and humans. While neighbouring countries have reported outbreaks RVF, Ghana has not yet identified any cases. The aim this study was to determine whether RVF virus (RVFV) circulating in livestock herders the southern part Ghana, estimate its seroprevalence, identify associated risk factors. surveyed 165 farms randomly selected from two districts Ghana. Serum samples 253 goats, 246 sheep, 220 cattle, 157 herdsmen...
Background: Bacteria are ubiquitous in the marine environment. Increasing concern for human health has led to growing interest contamination on public beaches. The presence of pathogenic microorganisms originating from anthropogenic activities such as defecation and disposal sewage beaches special concern. In this study, bacteria bacterial load beach zones point sources were investigated. Methods: Sand core samples subtidal zone, intertidal supratidal zone 5 Accra, Ghana, collected analysed....
The aim was to isolate and identify the species of mycobacteria causing tuberculous-like (TB-like) lesions in cattle Ghana.Between 2019 2020, 68 bovine tissue samples with TB-like lesions, identified during post slaughter examination, were obtained from four major abattoirs close border towns Ghana. cultured on Lowenstein-Jensen medium. Isolated bacteria characterized by Ziehl-Neelsen staining observation for acid-fast bacilli (AFB) under a microscope. DNA extracted AFB-positive isolates,...
While most Non-tuberculous mycobacteria (NTM) are saprophytic, several species have been associated with human diseases, from localized infection to disseminated diseases. Pulmonary NTM infections lead TB-like disease called pulmonary (NTM-PD). Due variation in treatment options among species, it is necessary identify the and determine drug susceptibility profiles inform choice of appropriate regimen for disease.
Although a lot of work has been done on the safety street foods in most developing countries, not much with regards to hotel industry. A pilot study investigate food and its preparation conditions ten selected hotels Accra, capital Ghana respect was therefore initiated 2005/2006. total 184 samples; 105 swabs kitchen working surfaces, cutlery plates; 29, 30, 20 samples food, water fruit juice respectively were taken for microbial analysis from highly patronized between December 2005 June...
Background: To better understand the extent of magnitude tuberculosis (TB) and Human Immunodeficiency Virus (HIV) co-infection in Ghana, a baseline study was conducted to establish national prevalence dual infection. The aimed determine most prevalent HIV serotype (HIV-1 or HIV-2) TB patients (new old cases); genotype mycobacterial species causing TB/HIV their drug susceptibility patterns. Methods: Sputum dried blood samples were collected from 503 67 health facilities nationwide between...