A5069936720- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Veterinary Orthopedics and Neurology
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Veterinary Equine Medical Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hip disorders and treatments
- Genetics and Plant Breeding
- Cancer-related gene regulation
- Veterinary Medicine and Surgery
- Veterinary Oncology Research
- Mechanisms of cancer metastasis
- Circular RNAs in diseases
- Animal Nutrition and Physiology
- Cancer, Lipids, and Metabolism
- Hereditary Neurological Disorders
- Educational Games and Gamification
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Wnt/β-catenin signaling in development and cancer
- Wikis in Education and Collaboration
- Immune Cell Function and Interaction
University of Copenhagen
2008-2025
Royal Agricultural University
2005
Obesity is a complex condition that increases the risk of life threatening diseases such as cardiovascular disease and diabetes. Studying gene regulation obesity important for understanding molecular mechanisms behind derived may lead to better intervention treatment plans. MicroRNAs (miRNAs) are short non-coding RNAs regulating target mRNA by binding their 3'UTR. They involved in numerous biological processes diseases, including obesity. In this study we use mixed breed pig model designed...
The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context obesity metabolic diseases because other widely models (e.g. mice) do not completely recapitulate key pathophysiological features associated with these humans. Therefore, we established F2 resource population (n = 564) designed elucidate genetics underlying phenotypes. Segregation traits was ensured by using breeds highly divergent...
Obesity is a rising worldwide public health problem. Difficulties to precisely measure various obesity traits and the genetic heterogeneity in human have been major impediments completely disentangle factors causing obesity. The pig relevant model for studying obesity-related (OOR) traits. Using founder breeds divergent with respect we created an F2 resource population (454 pigs), which has intensively phenotyped 36 OOR main rationale our study characterize architecture of design, by...
Summary Melanocortin 4 receptor (MC4R) is expressed in the appetite‐regulating areas of brain where it central regulation feed intake and energy balance. A mutation MC4R causing an Asp298Asn substitution has been associated with fatness, high daily gain pig. In a previously performed genome scan based on Hampshire × Landrace cross, we detected one quantitative trait loci (QTL) affecting carcass fat/meat ratio QTL biceps femoris muscle, both close to position porcine chromosome 1. this study,...
The first cases of early-onset progressive polyneuropathy appeared in the Alaskan Malamute population Norway late 1970s. Affected dogs were both sexes and ambulatory paraparetic, progressing to non-ambulatory tetraparesis. On neurologic examination, affected displayed predominantly laryngeal paresis, decreased postural reactions, spinal reflexes muscle atrophy. disease was considered eradicated through breeding programmes but recently new have occurred Nordic countries USA. N-myc...
Brachycephalic syndrome (BS) is a pathophysiological disorder caused by excessive soft tissue within the upper airways of short-nosed dog breeds, causing obstruction nasal, pharyngeal and laryngeal lumen, resulting in severe respiratory distress. As prevalence BS appears to be high among some affected there an urgent need for breeding efforts improve health status those dogs. In present study, we evaluated correlations between morphometric other phenotypic characteristics population 69...
Reprogramming of adipocyte function in obesity is implicated metabolic disorders like type 2 diabetes. Here, we used the pig, an animal model sharing many physiological and pathophysiological similarities with humans, to perform in-depth epigenomic transcriptomic characterization pure fractions. Using a combined DNA methylation capture sequencing Reduced Representation bisulfite (RRBS) strategy 11 lean 12 obese pigs, identified 3529 differentially methylated regions (DMRs) located at close...
Summary We report the identification of quantitative trait loci (QTL) affecting carcass composition, length, fat deposition and lean meat content using a genome scan across 462 animals from combined intercross backcross between Hampshire Landrace pigs. Data were analysed multiple linear regression fitting additive dominance effects. This model was compared with including parent‐of‐origin effect to spot evidence imprinting. Several precisely defined muscle phenotypes measured in order dissect...
Summary Canine hip dysplasia is characterized by poor joint conformation and laxity. The disease a complex trait influenced both genetics environment. Diagnosis quantification of are performed radiographic examination the diagnosis used for making breeding decisions in many breeds. A prognostic genetic test (the Dysgen test) based on seven associated SNPs has been developed study Spanish Labrador Retrievers. In our this evaluated 39 Danish Retrievers with known score: 14 (grade D or E) 25...
Abstract Background Approximately every fifth Dachshund is affected by disc herniation - a painful, hereditary condition which typically preceded calcification. Therefore, the selection of dogs suitable for breeding can be based on radiographic examination calcification status. Recently, an insertion FGF4 retrogene CFA12 has been identified and associated with risk developing in chondrodystrophic breeds DNA test now offered. In this study we investigate incidence smooth-haired, long-haired...
We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and related co-morbidities by crossing prone Göttingen Minipig breed with two lean production breeds. In this study we performed genome wide association (GWA) identify loci effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) haplotype analyses. Three separate haploblocks...
Abstract Background A pig phenotype characterized by juvenile hairlessness, thin skin and age dependent lung emphysema has been discovered in a Danish herd. The trait shows autosomal co-dominant inheritance with all three genotypes distinguishable. Since the resemblance to integrin β 6 -/- knockout seen mice, two genes encoding subunits of α v , i.e. ITGB6 ITGAV were considered candidate for this trait. Results mutated is hairlessness until puberty, few hair follicles absence musculi...
This paper covers videos created and used in different learning patterns. The are grouped according to the teaching or activities which they used. One group of by teacher for one-way communication, including: online lectures, experts interacting with one another, instruction introduction videos. Further teacher-student interactive videos, feedback on student deliveries, productions Examples from courses at faculties University Copenhagen types (screencasts, pencasts kinds camera recordings,...
Cholesterol is a ubiquitous steroid and vital component of cellular membranes in vertebrates. At the same time, subendothelial deposition cholesterol other lipoproteins culprit atherosclerotic lesions leading to range cardiovascular diseases which together represent most frequent causes death industrialized world. The balance between plasma levels low-density lipoprotein (LDL-C) high-density (HDL-C) critical for disease development. A high level LDL-C atherogenic whereas HDL-C cardio...
Abstract Cystinuria is a genetic disease that can lead to cystine urolith formation. The English bulldog the dog breed most frequently affected. In this breed, three missense mutations have been suggested be associated with cystinuria: c.568A>G and c.2086A>G in SLC3A1 c.649G>A SLC7A9 . study, occurrence of these Danish population bulldogs was investigated. Seventy‐one were genotyped using TaqMan assays. dogs’ owners given questionnaires concerning medical histories their dogs....
When the COVID-19 pandemic swept through Europe in 2020, veterinary educational institutions faced new challenges overnight: distance learning became imperative, and teachers were forced to develop e-learning material on fly. As a response unfortunate situation, faculties at three European universities (Utrecht, Copenhagen, Helsinki) applied for received an Erasmus+ grant international platform sharing material. Technical administrative caused slow start. This added already limited timeframe...
Heritabilities and genetic correlations were calculated using a BLUP-animal model, taking age (when appropriate), batch sex as fixed effects into account. An F2 population consisting of 450 pigs was created cross between Yorkshire Duroc * Gottingen minipig. The are typically lean pigs, selected for decades low fat content, leanness high growth rate. minipigs bred principally its small size known to be obesity.The resulting shows wide range phenotypic characteristics.