A5065273151- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Animal Disease Management and Epidemiology
- Endometrial and Cervical Cancer Treatments
- Tumors and Oncological Cases
- Virology and Viral Diseases
- Cancer Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Cancer and Skin Lesions
- Animal Nutrition and Physiology
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Viral Infections and Vectors
- Sarcoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Estrogen and related hormone effects
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Agriculture and Biological Studies
- Ovarian cancer diagnosis and treatment
University Hospital Hradec Králové
2023
University of Warmia and Mazury in Olsztyn
2020-2023
Charles University
2023
Gdańsk Medical University
2011-2020
The Maria Sklodowska-Curie National Research Institute of Oncology
2012
Medical University of Lodz
2012
Polish Academy of Sciences
1979-1984
Institute of Plant Genetics, Polish Academy of Sciences
1977-1978
National Veterinary Research Institute
1972-1977
Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression which harbors t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology lobulated growth pattern often composed microcystic, tubular, solid structures with abundant eosinophilic homogenous or bubbly secretions....
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of have been reported a variety epithelial and hematological malignancies. In salivary gland pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), has not documented any other type. The present study comprised clinical molecular analysis 25 cases morphologically immunohistochemically typical MASC. They all also displayed rearrangement as visualized by...
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This first series of MASC cases identified in historic cohort carcinomas glands with clinical/pathological correlation and follow-up data. We reviewed 183 primary major minor resected at Medical University Gdańsk, Poland, between 1992 2012. Based on morphology immunohistochemistry, suspicious for were selected, diagnosis was confirmed by fluorescence...
This study examines the presence of EWSR1 rearrangement in a variety clear cell salivary gland carcinomas with myoepithelial differentiation. A total 94 prominent component included 51 cases de novo (CCMC), 21 CCMCs ex pleomorphic adenoma (CCMCexPA), 11 epithelial-myoepithelial carcinoma (EMC), 6 EMC solid overgrowth, and 5 hyalinizing minor glands. In addition, 10 devoid change 12 benign myoepithelioma were as well. All tumors this spectrum reviewed, reclassified, tested by fluorescence...
Rationale: The etiology of sarcoidosis is unknown, but microbial agents are suspected as triggers.Objectives: We sought to identify bacterial, fungal, or viral lineages in specimens from patients with enriched relative control subjects using metagenomic DNA sequencing. Because environmental contamination contributes disproportionately samples low authentic content, we developed improved methods for filtering contamination.Methods: analyzed (n = 93), without 72), and various controls 150)....
Myoepithelial carcinoma of salivary glands is an underrecognized and challenging entity with a broad morphologic spectrum, including EWSR1-rearranged clear cell variant. generally aggressive largely unknown genetic features. A retrospective review Salivary Gland Tumor Registry in Pilsen searching for the key words "clear myoepithelial carcinoma," "hyalinizing cell," malignant myoepithelioma" yielded 94 carcinomas (CCMCs) molecular analysis EWSR1 rearrangement using fluorescence situ...
Salivary gland secretory carcinoma (SC), previously mammary analog SC, is a low-grade malignancy characterized by well-defined morphology and an immunohistochemical genetic profile identical to SC of the breast. Translocation t(12;15)(p13;q25) resulting in ETV6 :: NTRK3 gene fusion characteristic feature along with S100 protein mammaglobin immunopositivity. The spectrum alterations for continues evolve. aim this retrospective study was collect data salivary SCs correlate their histologic,...
The recurrent translocations t(11;19) and t(11;15) resulting in CRTC1-MAML2 or CRTC3-MAML2 fusion oncogenes, respectively, are identified a large proportion of mucoepidermoid carcinomas (MECs) the salivary gland have impact on prognosis. However, there conflicting data specificity this translocation, particular, its putative occurrence Warthin tumor (WT) parotid as reported few previous cases. It was speculated that extensive squamous metaplasia could explain presence translocation subset...
The present study was undertaken to evaluate real probability and pattern of cervical occult lymph node metastases (OLNM) in primary parotid carcinoma (PPC). We carried out a retrospective analysis 66 patients treated years 1992-2010 due PPC, who underwent elective neck dissection (END). In search risk factors for OLNM, we analysed the following parameters: age, sex, pT-Status, tumour size, skin invasion, facial nerve palsy, fixation, extraparotid extension, localization, grade, histology,...
Endometrial cancer (EC) is a hormone-related disease, showing highly diverse features of ER/PR/HER2 status-based molecular subtypes. Long noncoding RNA (lncRNA) HOX antisense intergenic (HOTAIR) has recently emerged as key molecule in many cancers, triggering epithelial-mesenchymal transition (EMT)-mediated stem cell (CSC) formation, but little known about its significance EC. Thus, we aimed to investigate the clinical HOTAIR itself different subtypes EC and possible links between HOTAIR,...
The aim of the study was to assess treatment results parotid gland salivary duct carcinoma (SDC). A retrospective clinicopathological analysis 40 patients treated for SDC in 1996–2015 performed. impact following factors on 5-year disease-free survival (DFS) and overall (OS) studied: age, sex, preoperative 7th nerve palsy, skin infiltration, pT, pN, surgical margin, type parotidectomy neck dissection, histology (SDC de novo vs. ex pleomorphic adenoma, SDCexPA), intra/periparotid lymph nodes...
Intratumor heterogeneity implies heterogeneous protein function, facilitating tumor adaptation which results in therapeutic failure. We hypothesized that at level may influence the course of disease. As a single biopsy might not represent full biologic complexity tumor, we have analyzed immunohistochemically four different cores obtained from each primary within cohort 364 patients with endometrial cancer (EC). The following proteins were examined: estrogen receptor 1 (ESR1), progesterone...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Majewska H, Skálová A, Radecka K, et al. Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study. Polish Journal Pathology. 2016;67(1):39-45. doi:10.5114/pjp.2016.59475. APA Majewska, H., Skálová, A., Radecka, K., Stodulski, D., Hyrcza, M., & Stankiewicz, C. (2016). Pathology, 67(1), 39-45. https://doi.org/10.5114/pjp.2016.59475 Chicago Hanna, Alena Klaudia...
Abstract Endometrial cancer (EC) is a hormone‐dependent, most frequent malignancy of the female genital tract, yet no molecular subtype classification based receptor status (estrogen [ER], progesterone [PR], human epidermal growth factor 2 [HER2]) has been established so far. Assuming that subtypes might differ fundamentally in EC, we analyzed expression levels ER, PR, and HER2 with immunohistochemistry aimed to determine clinical significance four subtypes: ER+/PR+/HER2+; ER+/PR+/HER2−,...
Intratumoral heterogeneity of breast cancer remains a major challenge in successful treatment. Failure therapies can also be accredited to inability systemically eradicate stem cells (CSCs). Recent evidence points the role epithelial-mesenchymal transition (EMT) expanding pool tumor with CSCs features. Thus, we assessed expression level as well markers primary tumors (PT), lymph node metastasis (LNM), and circulating (CTCs)–enriched blood fractions order correlate them signs EMT activation...
Malignant acanthosis nigricans is a rare paraneoplastic skin syndrome mostly associated with gastric adenocarcinoma. Florid cutaneous papillomatosis and tripe palms are considered to be abortive clinical variants of nigricans. Clinical manifestations include pruritic, hyperkeratotic hyperpigmented plaques subsequent formation velvety papillomas in the involved areas. This case report describes an unusual patient diagnosed combination malignant nigricans, florid
Thyroid transcription factor-1 (TTF-1) is a marker of tumors pulmonary and thyroid origin, its expression practically excludes diagnosis Merkel cell carcinoma (MCC). However, TTF-1 in combined MCC was recently reported. PAX5 B-cell origin that also expressed most classical cases; however, not described MCC. The authors decided to evaluate the both these markers group 5 MCCs (2 with invasive squamous carcinoma, 2 situ, 1 basal carcinoma). Expression found 4 3 cases, shown component (weakly...
Abstract Salivary gland carcinomas represent a heterogeneous group of poorly characterized head and neck tumors. The purpose this study was to evaluate ALK gene protein aberrations in large, well-characterized cohort these A total 182 salivary were tested for anaplastic lymphoma kinase (ALK) positivity by immunohistochemistry (IHC) using the cut-off 10% positive cells. tumors subjected FISH analysis followed hybrid capture–based next generation sequencing (NGS). Of tumors, 8 IHC. Further...
There are no clinically useful biomarkers predictive of brain metastases (BM) in breast cancer. In this study, we investigated the correlation between expression selected proteins primary tumor and risk BM patients with metastatic cancer (MBC).The study included 198 MBC (96 102 without BM). Using tissue microarrays derived from tumor, assessed by immunohistochemical ER, PR, HER2, Ki-67, CK5/6, EGFR, HER3, CXCR4, Rad51, E-cadherin, claudin 3 4.Ki-67 ≥14% (hazard ratio [HR] 2.76; P < 0.001),...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Majewska H, Skálová A, Weinreb I, et al. Giant cribriform adenocarcinoma of the tongue showing PRKD3 rearrangement. Polish Journal Pathology. 2016;67(1):84-90. doi:10.5114/pjp.2016.59223. APA Majewska, H., Skálová, A., Weinreb, I., Stodulski, D., Dziadziuszko, K., & Stankiewicz, C. (2016). Pathology, 67(1), 84-90. https://doi.org/10.5114/pjp.2016.59223 Chicago Hanna, Alena Ilan Dominik Katarzyna Czesław and...
Whilst the role of eukaryotic translation initiation factors (eIFs) has already been investigated in several human cancers, their endometrial cancer (EC) is relatively unknown. In present retrospective study, 279 patients with EC (1180 samples) were included (mean age: 63.0 years, mean follow-up: 6.1 years). Samples analysed for expression 7 eIFs subunits (eIF2α, eIF3c, eIF3h, eIF4e, eIF4g, eIF5, eIF6) through immunohistochemistry and western blotting. Fifteen samples healthy endometrium...