A5019132479- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Radiation Dose and Imaging
- Receptor Mechanisms and Signaling
- Sodium Intake and Health
- Advanced X-ray and CT Imaging
- Cholesterol and Lipid Metabolism
- Renal function and acid-base balance
- Pharmacology and Obesity Treatment
- Venous Thromboembolism Diagnosis and Management
- Sleep and related disorders
- Sleep and Wakefulness Research
- Ovarian cancer diagnosis and treatment
- Urinary and Genital Oncology Studies
- Endometriosis Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Eicosanoids and Hypertension Pharmacology
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Endometrial and Cervical Cancer Treatments
- Obstructive Sleep Apnea Research
- Antioxidant Activity and Oxidative Stress
- Electrolyte and hormonal disorders
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
University Hospital of Zurich
2015-2023
Memorial Sloan Kettering Cancer Center
2017-2021
New York Proton Center
2020
University of Zurich
2015-2019
University of Fribourg
2004-2019
University of Bern
1980-2015
University Hospital of Bern
1987-2014
University of Göttingen
2004-2006
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2005
Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of care for the management muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin-based regimens have yielded favorable outcomes compared with standard-dose chemotherapy, yet optimal neoadjuvant regimen remains undefined. We assessed efficacy and tolerability six cycles dose-dense gemcitabine cisplatin (ddGC) in patients MIBC. Patients Methods In this prospective, multicenter phase II study, received ddGC...
Abstract: The aim of this prospective study was to document radiographically tissue remodeling patterns around ITI® implants placed according an osteotome technique. In 19 consecutive patients from a private practice, 25 the Dental Implant System were subjacent sinus floor. beds pre‐prepared with pilot drills and/or using Summers Osteotome Kit®. Bio Oss® particles mixed autologous bone and inserted into apex area. Implants self‐tapping. floors thereby pushed up attempts not sever...
Article AbstractObjective: Ziprasidone, an atypical antipsychotic, is a potent dopamine (D2) and serotonin (5-HT2A/C) receptor blocker, has agonistic properties at the 5-HT1A receptor, blocks norepinephrine reuptake. These transmitter systems are closely related to regulation of sleep. Method: The aim this double-blind, placebo-controlled, randomized, crossover study was investigate effects ziprasidone on polysomnographic sleep structure subjective quality. Twelve healthy male subjects were...
The role of various pressor factors and cardiovascular responsiveness to norepinephrine or angiotensin II in the pathogenesis borderline hypertension was evaluated. Exchangeable body sodium, blood volume, plasma renin activity, dopamine levels, epinephrine excretion rates were similar between 24 patients with (mean age 34 +/- 4 (SEM) years 22 normal subjects matched for age; had a slight increase supine epinephrine. Pressor doses significantly lower (p less than 0.01 0.001, respectively)...
The role of the adrenergic effector-response axis in pathogenesis essential hypertension and hypotensive mechanism diuretic treatment was evaluated by combined analysis plasma catecholamine levels pressor sensitivity to norepinephrine (NE).Under placebo conditions, NE, epinephrine dopamine concentrations did not differ significantly between normal subjects patients with borderline or established hypertension. dose (δ mean blood pressure + 20 mm Hg) infused NE correlated positively (P < 0.05)...
Fourteen patients with untreated mild to moderate essential hypertension had on average an abnormally high cardiovascular reactivity exogenous noradrenaline and angiotension II, while plasma noradrenaline, renin activity, exchangeable body sodium, blood volume were normal. Treatment a low dose of indapamide (2.5 mg/day) for six weeks decreased pressure by 10% in these hypertensive but not 13 normal control subjects. Plasma or sodium changed significantly; nevertheless, the latter, weight,...
The objective of this study was to assess the discriminative power dual-energy computed tomography (DECT) versus single-energy CT (SECT) distinguish between ferromagnetic and non-ferromagnetic ballistic projectiles improve safety regarding magnetic resonance (MR) imaging studies in patients with retained projectiles.Twenty-seven including 25 bullets (diameter, 3-15 mm) 2 shotgun pellets (2 mm each) were examined an anthropomorphic chest phantom using 128-section dual-source CT. Data...
18F-fluorodihydrotestosterone (18F-FDHT) is a radiolabeled analog of the androgen receptor's primary ligand that currently being credentialed as biomarker for prognosis, response, and pharmacodynamic effects new therapeutics. As part qualification process, we prospectively assessed its reproducibility repeatability in men with metastatic castration-resistant prostate cancer. Methods: We conducted prospective multiinstitutional study cancer patients undergoing 2 (test/retest) 18F-FDHT PET/CT...
The acute responsiveness of plasma catecholamine, renin (PRA), and aldosterone levels to exogenous norepinephrine was studied under placebo conditions following renin-angiotensin activation by diuretic pretreatment in 25 normal subjects 34 patients with borderline-to-moderate essential hypertension. Norepinephrine infusion caused increases (PNE) that correlated the infused dose (p < 0.001); this relationship similar hypertensive unaltered therapy. Plasma epinephrine dopamine were unchanged...