A5010069485- Glaucoma and retinal disorders
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Treatment and Management
- Diabetes Management and Research
- Diet and metabolism studies
- Pharmacology and Obesity Treatment
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Parkinson's Disease Mechanisms and Treatments
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- Obesity and Health Practices
- Behavioral Health and Interventions
- Pain Management and Opioid Use
- Pancreatic function and diabetes
- Retinal Diseases and Treatments
- Advanced Glycation End Products research
- Metabolism, Diabetes, and Cancer
- Pressure Ulcer Prevention and Management
- Neuroblastoma Research and Treatments
- Muscle metabolism and nutrition
- Eating Disorders and Behaviors
- Nutritional Studies and Diet
- Receptor Mechanisms and Signaling
University of Liverpool
2017-2024
NIHR Manchester Biomedical Research Centre
2024
Manchester University NHS Foundation Trust
2023-2024
Manchester Academic Health Science Centre
2024
University of Manchester
2024
Manchester Royal Infirmary
2023-2024
NIHR Wellcome Trust Southampton Clinical Research Facility
2024
Aintree University Hospital
2017-2023
Aintree University Hospitals NHS Foundation Trust
2018
Abstract Aims/hypothesis Corneal confocal microscopy is a rapid non-invasive ophthalmic imaging technique that identifies peripheral and central neurodegenerative disease. Quantification of corneal sub-basal nerve plexus morphology, however, requires either time-consuming manual annotation or less-sensitive automated image analysis approach. We aimed to develop validate an artificial intelligence-based, deep learning algorithm for the quantification fibre properties relevant diagnosis...
An effective prescribing pathway for liraglutide 3 mg, an approved obesity pharmacotherapy, may improve treatment access. This trial compared a targeted mg with multiple stopping rules in specialist weight management services (SWMS) to standard SWMS care.
Peripheral neuropathy is reported in obesity even the absence of hyperglycaemia. To compare prevalence and characterise phenotype peripheral people living with (OB) long-duration type 1 diabetes (T1D). We performed a prospective cross-sectional study 130 participants including healthy volunteers (HV) (n = 28), T1D 51), OB (BMI 30–50 kg/m2) 51). Participants underwent assessment neuropathic symptoms (Neuropathy Symptom Profile, NSP), neurological deficits Disability Score, NDS), vibration...
In this study, we evaluate small and large nerve fibre pathology in relation to diabetic foot ulceration (DFU) incident cardiovascular cerebrovascular events type 1 diabetes (T1D).A prospective observational study was conducted on people with T1D without peripheral neuropathy (DPN) (n = 25), DPN 28), DFU 25) 32 healthy volunteers. ROC analysis of parameters diagnose DFU, multivariate Cox regression performed the predictive ability corneal nerves for cardiac over 3 years.Corneal length...
Summary Resting energy expenditure (REE) and metabolic fuel utilization (carbohydrate or fat) proxied by respiratory quotient (RQ) from indirect calorimetry enables more precise measurement of needs fat oxidation capacity. The study compared the effectiveness providing information during diet exercise weight intervention versus standard care (SOC) on loss outcomes. Fifty‐two participants with obesity were recruited a specialist service, randomized 1:1 to (INT) SOC only. Participants in INT...
Introduction In the UK and Ireland, severe complex obesity is managed in specialist weight management services (SWMS), which provide multicomponent lifestyle interventions to support loss, use of medication if available. Liraglutide 3 mg (LIRA mg) an effective weight-loss medication, but loss individual patients variable, its efficacy has not been assessed SWMS. This study aims investigate whether a targeted prescribing pathway for LIRA with multiple prespecified stopping rules could help...
Introduction Respiratory quotient (RQ) provides an indication of the relative balance carbohydrate and fat oxidation. RQ could serve as early biomarker negative energy during weight loss. Restriction intake to total daily requirements produces a which can lead fall in RQ, accompanied by decrease resting expenditure (REE). However, net change body does not usually match predicted due intraindividual metabolic adaptations. Our aim is determine effectiveness utilising EE information from...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)