A5083091323- Inflammatory Bowel Disease
- Microscopic Colitis
- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Urticaria and Related Conditions
- Antibiotic Resistance in Bacteria
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal Tumor Research and Treatment
- Celiac Disease Research and Management
- Metabolism and Genetic Disorders
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Clinical Nutrition and Gastroenterology
- Helicobacter pylori-related gastroenterology studies
- Congenital gastrointestinal and neural anomalies
- Immune Cell Function and Interaction
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
Children's Hospital of Zhejiang University
2015-2025
Zhejiang University
2007-2024
National Clinical Research
2024
Weatherford College
2021
Creative Commons
2021
National Natural Science Foundation of China
2021
Edinburgh Royal Infirmary
2009
Boston Children's Hospital
2009
Sir Run Run Shaw Hospital
2007
Exclusive enteral nutrition (EEN) is recommended as first-line therapy for children with mild to moderate Crohn's disease (CD), given its effectiveness in inducing clinical remission (CR) and promoting mucosal healing (MH). However, the identification of reliable early predictors EEN response remains an area requiring further investigation. Patients CD diagnosed between 2015 2024 were divided into training validation cohorts. Baseline laboratory covariates analyzed separately evaluate their...
ABSTRACT Congenital tufting enteropathy (CTE) is a rare autosomal recessive inherited disorder caused by mutations in the epithelial cell adhesion molecule ( EpCAM ) gene, characterized severe diarrhea and growth failure. Between December 2017 2023, eight patients diagnosed with CTE at our hospital were retrospectively analyzed for their clinical genetic features, alongside comprehensive literature review. All presented malnutrition failure upon admission. Parenteral nutrition (PN) high...
Acinetobacter baumannii has emerged as an important opportunistic pathogen due to its ability acquire resistance most currently available antibiotics. Colistin is often considered the last line of therapy for infections caused by multidrug-resistant A. (MDRAB). However, a colistin-resistant strain recently been reported. To explore how multiple drug-resistant responds colistin resistance, we compared genomic, transcriptional and proteomic profile MDR-ZJ06 induced ZJ06-200P5-1. Genomic...
To analyze clinical differences between monogenic and nonmonogenic very-early-onset inflammatory bowel disease (VEO-IBD) to characterize IBD phenotypically genotypically
Mycoplasma pneumoniae (M. pneumoniae) infection can cause community acquired pneumonia in children. A real-time method of simultaneous amplification and testing M. (SAT-MP) was developed to diagnose targeting a region the ribosomal RNA. The SAT-MP assay accurately identify with detection range from 101 107 CFU/ml. In this study, specimens 315 children were collected analyzed by parallel PCR IgM ELISA assay. positive rates these examined assay, 16.51%, 15.56% 12.70% respectively. While there...
To compare the effectiveness of exclusive enteral nutrition (EEN) and infliximab (IFX) therapy in pediatric Crohn's disease (CD). In a prospective study children initiating EEN or for CD, we compared clinical outcomes using activity index (PCDAI), growth improvement, endoscopic mucosal healing, adverse effects. Data were measured at baseline after 8 weeks therapy. We enrolled 26 with CD; whom, 13 treated infliximab, EEN. Clinical response (PCDAI) reduction ≥ 15 final PCDAI ≤ 10 was achieved...
Gut dysbiosis is closely related to dysregulated microRNAs (miRNAs) in the intestinal epithelial cells, which plays an important role pathogenesis of Crohn's disease (CD). We investigated relationship between fecal gut microbiome (GM) and tissue miRNAs different stages pediatric CD. Metagenomic analysis miRNA sequencing were conducted examine GM profiles CD patients before after clinical induction therapy controls. Twenty-seven newly diagnosed, therapy-naïve with active 11 non-inflammatory...
Intestinal lymphangiectasia (IL) is a rare disease characterized by dilated lymphatic vessles in the intestinal wall and small bowel mesentery which induce loss of protein lymphocytes into lumen.Because it most often occurs intestine cannot be detected upper gastroendoscopy or colonoscopy, value common image examinations such as X-ray computerized tomography (CT) are limited, diagnosis IL difficult, usually needing help surgery.Capsule endoscopy useful diagnosing diseases, IL.We here report...
Acinetobacter baumannii is an important bacterium that emerged as a significant nosocomial pathogen worldwide. The rise of A. was due to its multi-drug resistance (MDR), while it difficult treat resistant with antibiotics, especially in pediatric patients for the therapeutic options antibiotics were quite limited patients. ST208 identified predominant sequence type carbapenem United States and China. As we knew, there no complete genome reproted ST208, although several whole shotgun...
To reconstruct the evolutionary history of clinical Acinetobacter baumannii XH1056, which lacks Oxford scheme allele gdhB.Susceptibility testing was performed using broth microdilution and agar dilution. The whole-genome sequence XH1056 determined Illumina Nanopore platforms. MLST Pasteur scheme. Antibiotic resistance genes were identified ABRicate.XH1056 resistant to all antibiotics tested, apart from colistin, tigecycline eravacycline. assigned ST256. However, could not be typed with as...
Salmonella enterica is a zoonotic food-borne pathogen threatening public health around the world. As case with many other pathogens, spread of mobilized colistin resistance (mcr) alleles grave concern. In this study, totally 689 clinical isolates were collected from local hospital in Hangzhou, Zhejiang Province, China between 2009 and 2018. Resistance genes screen by PCR. Two mcr-9-positive strains S15 S639 identified which belong to serotype Typhimurium Thompson, respectively. We observed...
Variants in the MSN gene were recently reported as cause of a primary immunodeficiency disease called X-linked moesin-associated (X-MAID). Hitherto, only 10 patients worldwide. Here, we report boy who presented with recurrent high fever, oral ulcers, abdominal pain, and hematochezia for over 2 weeks. His serum inflammatory markers elevated, colonoscopy showed multiple colon ulcers terminal ileum which resemble colitis caused by bowel disease. A novel heterozygous variant...
AIM:To investigate the diagnostic yield of capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB), and to determine whether was affected by different status. METHODS:Three hundred nine consecutive (all recent negative gastric colonic results) were investigated CE; 49 cases massive 260 chronic recurrent overt bleeding.Data regarding OGIB obtained retrospective chart review an internal database CE findings. RESULTS:Visualization entire small intestine achieved 81.88%...
Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia carcinoma. It rare in paediatric cohorts. We present the case of boy with whom immune dysregulation, polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome was confirmed by FOXP3 gene mutation. patient referred hospital at age 3 years recurrent emesis,...
Background: Children presenting with chronic liver disease or acute failure often have an underlying genetic disorder. The aim of this study was to analyze the clinical and spectra inherited in children a tertiary hospital. Methods: A total 172 patients were classified into three groups according their presentation: cholestasis (Group A), enzyme elevation B), hepato/splenomegaly C). Next-generation sequencing (NGS) performed on all recruited study. genotypic phenotypic these reviewed....
Background. Both exclusive enteral nutrition (EEN) and infliximab (IFX) are recommended as induction therapy for pediatric Crohn’s disease (CD). Our aim was to compare long-term outcomes of patients initially received with either IFX or EEN. Methods. Medical records newly diagnosed, naïve CD EEN were retrospectively enrolled. Pediatric activity index (PCDAI), endoscopic severity (CDEIS), other clinical data compared pre- postinduction in two groups. The sustained remission rates time coupled...
Congenital tufting enteropathy (CTE) is a rare disease that manifests as intractable diarrhea during the neonatal period which associated with mutations of epithelial cell adhesion molecule (EpCAM) gene.A male infant who presented vomiting, diarrhea, abdominal distention, malnutrition and growth failure was admitted to our department when he 2 months old. His parents were healthy nonconsanguineous. Etiologic examinations stool, inflammatory markers, blood gas electrolytes levels, serum...
Transient infantile hypertriglyceridemia is a rare autosomal recessive disorder characterized by hypertriglyceridemia, hypohepatia, hepatomegaly, hepatic steatosis and fibrosis in infancy. Mutations GPD1 gene are considered the causative factor but underlying mechanism of this still enigmatic. To date, only 24 different mutations have been reported literature worldwide with transient or relevant conditions. Here we report Chinese girl who developed hepatomegaly steatosis, elevated...