A5044490703- Salivary Gland Disorders and Functions
- Ion channel regulation and function
- Parasitic infections in humans and animals
- Ideological and Political Education
- Congenital Anomalies and Fetal Surgery
- Epilepsy research and treatment
- Innovative Teaching Methods
- S100 Proteins and Annexins
- RNA Research and Splicing
- Video Analysis and Summarization
- Neuroscience and Neuropharmacology Research
- Systemic Lupus Erythematosus Research
- Cardiac electrophysiology and arrhythmias
- Geothermal Energy Systems and Applications
- Immunotherapy and Immune Responses
- Multimodal Machine Learning Applications
- vaccines and immunoinformatics approaches
- Plant-based Medicinal Research
- Viral gastroenteritis research and epidemiology
- Amoebic Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Innovative Educational Techniques
- Bacteriophages and microbial interactions
- Circular RNAs in diseases
- Neuroscience and Neural Engineering
Dongguan People’s Hospital
2019-2022
Nanfang Hospital
2020-2022
Southern Medical University
2019-2022
Xinjiang Medical University
2008-2019
Guangdong Provincial People's Hospital
2019
Biogen (United States)
2016-2017
Guangdong Academy of Medical Sciences
2011
Guangdong General Hospital
2011
First Affiliated Hospital of Xinjiang Medical University
2008
This paper introduces MiniGPT4-Video, a multimodal Large Language Model (LLM) designed specifically for video understanding. The model is capable of processing both temporal visual and textual data, making it adept at understanding the complexities videos. Building upon success MiniGPT-v2, which excelled in translating features into LLM space single images achieved impressive results on various image-text benchmarks, this extends model's capabilities to process sequence frames, enabling...
Abstract Despite being one of the most common rheumatologic diseases, there is still no disease-modifying drug for primary Sjögren’s syndrome (pSS). Advancing our knowledge target tissue has been limited by low dimensionality histology techniques and small size human salivary gland biopsies. In this study, we took advantage a molecularly validated mouse model pSS to characterize tissue-infiltrating CD4+ T cells their regulation lymphotoxin/LIGHT signaling axis. Novel cell subsets were...
The purpose of the present studies was to use CyTOF and RNA-Seq technologies identify cells genes involved in lacrimal gland repair that could be targeted treat diseases dysfunction. Lacrimal glands female BALB/c mice were experimentally injured by intra-glandular injection interleukin 1 alpha (IL-1α). harvested at various time points following injury (1 14 days) used either prepare single cell suspensions for immuno-phenotyping analyses or extract RNA gene expression using RNA-Seq....
Abstract Purpose The aim of this was to discover disease‐causing gene mutations linked genetic epilepsy with febrile seizures plus (GEFS+) in a family the Southern Chinese Han population. Of three‐generation pedigree 18 members family, 4 were affected GEFS+. Method Blood samples 7 members—3 and unaffected individuals—were collected. Whole‐exome sequencing performed assess for two individuals individuals. Results Fourteen potentially consequential found validated Sanger method. DNA tested...
Traditional board writing and other teaching methods make it difficult to present the microscopic world of microorganisms students. We used many modern multimedia teaching, QQ, WeChat, MOOCs in medical microbiology allow students clearly recognize microcosmic ensure quality teaching.
To investigate the gene mutations of CHRNB2 and CHRNA2 in Chinese population with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).One hundred six Han nationality patients (74 sporadic 32 familial) were recruited studied. Mutational screening was performed by sequencing all 6 coding exons 7 including donor acceptor splice sites.The results excluded involvement known published genes. However, a novel synonymous mutation c.483C>T (H161H) single nucleotide polymorphism (c.1407C>G)...
Abstract Background Colorectal cancer (CRC) is the third most frequently diagnosed with rising incidence and mortality rates. Telomere RNA component (TERC) plays a crucial role in various biological processes tumor development, although its CRC development metastasis remains unknown. Methods The proliferation invasion of TERC-overexpressing TERC-knockdown cells were analyzed by standard cellular assays animal models. underlying mechanisms investigated RT-PCR, western blotting fluorescence...
Based on the characteristic of course medical Microbiology and Immunology, there are many advantages with multimedia teaching method. However, also some disadvantages method compared traditional methods. It is benefit students to improve effect quality while teachers combine methods in microbiology immunology.
8085 Background: Altered NF-kB2 activation is found in many human cancers although the exact mechanisms and affected pathways are not clear. We investigated these questions a unique transgenic mouse model with lymphocyte targeted expression of p80HT, lymphoma associated mutant (Zhang et al.). This shares features multiple myeloma (MM) including elevated bone marrow plasma cells an M spike some mice. Methods: Microarray analysis was performed on B p80HT mice, which produced serum monoclonal...
Abstract Echinococcus granulosus (E. granulosus) is a small parasitic flat worm that would cause zoonosis named Cystic echinococcosis (CE), which leads to serious healthy and economic damage all over the world. To prevent spread of disease, vaccine against E. has become one most effective strategies nowadays. According previous research, Eg14-3-3 protein an important candidate antigen granulosus. Therefore, serval bioinformatics approaches were used analyze spatial structure linear B-cell...
Abstract Background: DDX39B is a member of the DEAD box (DDX) RNA helicase family required for nearly all cellular metabolism processes. The exact role and potential molecular mechanism in progression human colorectal cancer (CRC) remain to be investigated. Methods: Western blotting quantitative real-time PCR (qRT-PCR) were conducted detect expression CRC tissues cell lines. Transwell wound healing assays assess migration invasion ability cells with overexpressed or silencing. Orthotopic...
Genetic epilepsy with febrile seizures plus (GEFS+) is a type of epileptic syndrome closely related to heredity factors, which can be caused by gene mutations. However, it still remains unclear how these mutations result in seizures. Previously, we identified new heterozygous missense mutation the KCNAB3 gene, H258R, GEFS+ family; electric currents human embryonic kidney 293 (HEK293) cells co-expressing Kvβ3 (H258R) and Kv1.1 showed obvious inactivation. This study sought examine effects...