A5083328121- Research on Leishmaniasis Studies
- Cell death mechanisms and regulation
- Educational Outcomes and Influences
- Toxoplasma gondii Research Studies
- Toxin Mechanisms and Immunotoxins
- Educational theories and practices
- Trypanosoma species research and implications
- Stress and Burnout Research
- Psychology Research and Bibliometrics
- Higher Education Teaching and Evaluation
- Educational Methods and Psychological Studies
- Health and Lifestyle Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Cytomegalovirus and herpesvirus research
- Synthesis and Biological Evaluation
- Business, Education, Mathematics Research
- Parasites and Host Interactions
- Occupational Health and Safety Research
- Educational and Psychological Assessments
- Parasitic Infections and Diagnostics
- Psychometric Methodologies and Testing
- Immunotherapy and Immune Responses
- Psychological Testing and Assessment
- Health and Medical Education
Benito Juárez Autonomous University of Oaxaca
2024
Universidad Nacional Autónoma de México
2016-2023
Instituto Nacional de Cardiología
2018-2023
Universidad Autónoma de la Ciudad de México
2022
Dendritic cells (DC) along with macrophages are the main host of intracellular parasite Leishmania. DC traverse a process maturation, passing through an immature state phagocytic ability to mature one where they can modulate immune response secretion cytokines. Several studies have demonstrated that Leishmania inhibits maturation. Nevertheless, when subjected second stimulus such as LPS/IFN-γ, manage mature. In maturation DC, several signaling pathways been implicated, importantly MAPK. On...
The intracellular parasite Leishmania mexicana inhibits camptothecin (CPT)-induced apoptosis of monocyte-derived dendritic cells (moDC) through the down-regulation p38 and JNK phosphorylation, while kinase Akt is maintained active for 24 h. In addition, infection moDC with L. promastigotes increases protein presence antiapoptotic Bcl-xL. present work, we aimed to investigate role in inhibition by modulation expression proteins Bcl-2, Mcl-1 were infected metacyclic treated CPT, an inhibitor,...
Abstract A series of novel 4‐acetyl‐1,3,4‐oxadiazole derivatives was designed and synthesized for their biological evaluation in vitro against Trypanosoma cruzi ( T. ) Leishmania mexicana L. ). Additionally, all compounds were evaluated by molecular docking on the cruzain Tc Cz) cysteine protease B (CPB) Lm CPB) to know potential mechanism binding. Compound OX‐12 had better trypanocidal activity NINOA (IC 50 =10.5 μM) A1 =21.7 strains that reference drug benznidazole =30.3 μM 39.8 μM,...