A5089745349- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Enzyme function and inhibition
- Biochemical and Molecular Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Synthesis and Reactions of Organic Compounds
- Diabetes Treatment and Management
- Cholinesterase and Neurodegenerative Diseases
- Quinazolinone synthesis and applications
- Pesticide Residue Analysis and Safety
- Cancer Mechanisms and Therapy
- Calcium signaling and nucleotide metabolism
- Pancreatic function and diabetes
- Synthesis and biological activity
- Insect Resistance and Genetics
- Antibiotics Pharmacokinetics and Efficacy
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Cytokine Signaling Pathways and Interactions
- Drug Transport and Resistance Mechanisms
- Parasite Biology and Host Interactions
- Morinda citrifolia extract uses
Instituto Politécnico Nacional
2019-2025
Background/Objectives: Pork tapeworm Taenia solium is the causative agent of cysticercosis which may develop in muscle tissue, skin, eyes, and central nervous system (neurocysticercosis). It estimated by World Health Organization (WHO) that about 2.56–8.30 million are infected worldwide. Praziquantel albendazole used for anthelminthic treatment neurocysticercosis; however, not all patients have a complete elimination cysts, makes it necessary to seek new improved options. Methods: In this...
The primary strategy for managing Nacobbus aberrans has traditionally relied on synthetic chemicals. However, increasing regulatory pressure unsafe products led to a growing research focus nematicides. Despite this, chemical nematicides remain more effective than other control methods. Consequently, there is pressing need develop novel that are both and environmentally safer. This study aimed evaluate the nematocidal efficacy of various molecules against second-stage juveniles N. aberrans,...
In this study, n-butyl and iso-butyl quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives were evaluated in vitro against Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), Entamoeba histolytica (E. histolytica). The potential mechanism of action determination was approached by silico analysis on G. T. triosephosphate isomerase (GlTIM TvTIM, respectively), E. thioredoxin reductase (EhTrxR). Enzyme inactivation assays performed recombinant GlTIM EhTrxR. Compound T-167 showed...
Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. depends on glycolysis as source of adenosine triphosphate (ATP) supply, triosephosphate isomerase (TIM) plays key role in this metabolic pathway. This enzyme an attractive target for the design new trypanocidal drugs. In study, ligand-based virtual screening (LBVS) from ZINC15 database using benzimidazole scaffold was accomplished. Later, molecular docking interface TIM (TcTIM) performed compounds were...
Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine available to prevent the disease, and medical treatments cause serious side effects. Additionally, treatment failure parasite resistance have made development of new drugs against CL necessary. In this work, virtual screening natural products from BIOFACQUIM Selleckchem databases was performed using method molecular docking at triosephosphate isomerase (TIM) enzyme interface...
Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), “Neglected disease”, for which the search new drugs priority. Benzimidazole scaffold used to develop antiparasitic drugs; therefore, it interesting molecule against L. mexicana. In this work, ligand-based virtual screening (LBVS) ZINC15 database was performed. Subsequently, molecular docking predict compounds with potential binding at dimer interface triosephosphate isomerase (TIM) (LmTIM). Compounds were...
Background: Diabetes mellitus is a metabolic disease that causes multiple complications and common comorbidities, which decreases the quality of life for people affected by disease. Sodium glucose cotransporter type 2 (SGLT2) participates in reabsorption 90% kidneys; therefore, it an attractive drug target controlling blood levels. Objective: The aim this work was to obtain new potential SGLT2 inhibitors. Methods: A ligand-based virtual screening (LBVS) from ZINC15, PubChem ChemSpider...
Phenothiazine derivatives can unselectively inhibit the trypanothione-dependent antioxidant system enzyme trypanothione reductase (TR). A virtual screening of 2163 phenothiazine from ZINC15 and PubChem databases docked on active site T. cruzi TR showed that 285 compounds have higher affinity than natural ligand disulfide. 244 toward parasite's to its human homolog glutathione reductase. Protein-ligand interaction profiling predicted main interactions for top scored were with residues...
n -, and isobutyl esters of quinoxaline-1,4-di- N -oxide are effective anti-tuberculosis agents against replicating non-replicating H37Rv bacilli, with top ten lead compounds being relatively safe selectivity index values over 70.
Chagas disease has an ineffective drug treatment despite efforts made over the last four decades. The carbonic anhydrase of Trypanosoma cruzi (α-TcCA) emerged as interesting target for design new antiparasitic compounds due to its crucial role in parasite processes.
Abstract A series of novel 4‐acetyl‐1,3,4‐oxadiazole derivatives was designed and synthesized for their biological evaluation in vitro against Trypanosoma cruzi ( T. ) Leishmania mexicana L. ). Additionally, all compounds were evaluated by molecular docking on the cruzain Tc Cz) cysteine protease B (CPB) Lm CPB) to know potential mechanism binding. Compound OX‐12 had better trypanocidal activity NINOA (IC 50 =10.5 μM) A1 =21.7 strains that reference drug benznidazole =30.3 μM 39.8 μM,...
In this study, the aim was to identify and quantify antibiotic residues in pork meat samples of supermarkets butcher shops two main cities northeast Mexico, using Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS). The results shown seven detected samples. Ampicillin with a higher positive rate (>59%) shops. Tetracycline sulfamethazine had high (>25%). Finally, quantification antibiotics that exceed minimum limits (MRL). study suggests an inadequate management food industry...
Currently, protozoan infectious diseases affect billions of people every year. Their pharmacological treatments offer few alternatives and are restrictive due to undesirable side effects parasite drug resistance.In this work, three ontology-based approaches were used identify shared potential targets in five species protozoa.In study, proteomes protozoa: Entamoeba histolytica (E. histolytica), Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), Trypanosoma cruzi cruzi),...
Diversos microorganismos han sido reportados por su eficacia en la biodegradación de contaminantes como plaguicidas gracias a sus características metabólicas. En este estudio, se aislaron e identificaron bacterias suelos agrícolas las cuales mostraron ser capaces tolerar pesticidas y utilizarlos única fuente carbono energía. Se evaluaron cinco más comúnmente utilizados (sales dimetilaminas, tri-isopropanolaminas glifosato, atrazina carbofuran) diferentes concentraciones utilizando dos medios...