A5052759042- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Synthesis and Reactions of Organic Compounds
- Parasite Biology and Host Interactions
- Diabetes Treatment and Management
- Calcium signaling and nucleotide metabolism
- Enzyme function and inhibition
- HIV/AIDS Research and Interventions
- Insect symbiosis and bacterial influences
- SARS-CoV-2 and COVID-19 Research
- Pesticide and Herbicide Environmental Studies
- Parasites and Host Interactions
- Synthesis and Catalytic Reactions
- Pancreatic function and diabetes
- Parasitic Infections and Diagnostics
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial bioremediation and biosurfactants
- Environmental Toxicology and Ecotoxicology
- Diverse Scientific Research Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
Instituto Politécnico Nacional
2020-2025
Methylmalonic acidemia (MMA) is a genetic condition associated with intellectual disability and high mortality rate. It caused by pathogenic variants in the MMUT gene, which codes methylmalonyl-CoA mutase enzyme (MUT). In Mexican population, variant NM_000255.4:c.322C>T or p.(Arg108Cys) most frequently found, but its structural effect scarcely studied. To describe clinical picture of homozygous patients to predict effect, we performed an analysis medical files from six MMA patients. The...
The primary strategy for managing Nacobbus aberrans has traditionally relied on synthetic chemicals. However, increasing regulatory pressure unsafe products led to a growing research focus nematicides. Despite this, chemical nematicides remain more effective than other control methods. Consequently, there is pressing need develop novel that are both and environmentally safer. This study aimed evaluate the nematocidal efficacy of various molecules against second-stage juveniles N. aberrans,...
In this study, n-butyl and iso-butyl quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives were evaluated in vitro against Giardia lamblia (G. lamblia), Trichomonas vaginalis (T. vaginalis), Entamoeba histolytica (E. histolytica). The potential mechanism of action determination was approached by silico analysis on G. T. triosephosphate isomerase (GlTIM TvTIM, respectively), E. thioredoxin reductase (EhTrxR). Enzyme inactivation assays performed recombinant GlTIM EhTrxR. Compound T-167 showed...
Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. depends on glycolysis as source of adenosine triphosphate (ATP) supply, triosephosphate isomerase (TIM) plays key role in this metabolic pathway. This enzyme an attractive target for the design new trypanocidal drugs. In study, ligand-based virtual screening (LBVS) from ZINC15 database using benzimidazole scaffold was accomplished. Later, molecular docking interface TIM (TcTIM) performed compounds were...
Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries worldwide. No vaccine available to prevent the disease, and medical treatments cause serious side effects. Additionally, treatment failure parasite resistance have made development of new drugs against CL necessary. In this work, virtual screening natural products from BIOFACQUIM Selleckchem databases was performed using method molecular docking at triosephosphate isomerase (TIM) enzyme interface...
Leishmania mexicana (L. mexicana) is a causal agent of cutaneous leishmaniasis (CL), “Neglected disease”, for which the search new drugs priority. Benzimidazole scaffold used to develop antiparasitic drugs; therefore, it interesting molecule against L. mexicana. In this work, ligand-based virtual screening (LBVS) ZINC15 database was performed. Subsequently, molecular docking predict compounds with potential binding at dimer interface triosephosphate isomerase (TIM) (LmTIM). Compounds were...
In the last years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused more than 760 million infections and 6.9 deaths. Currently, remains a public health problem with limited pharmacological treatments. Among virus drug targets, SARS-CoV-2 spike protein attracts development of new anti-SARS-CoV-2 agents.
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a fast-spreading viral pathogen and poses serious threat to human health. New SARS-CoV-2 variants have been arising worldwide; therefore, necessary explore more therapeutic options. interaction of the spike (S) protein with angiotensin-converting enzyme (ACE2) host receptor an attractive drug target prevent infection via inhibition virus cell entry. In this study, Ligand- Structure-Based Virtual Screening (LBVS SBVS) was...
Cypermethrin (CYP) is an insecticide pyrethroid used in the agriculture for its broad-spectrum activity. However, recent studies have shown accumulation of CYP soil, and water a high toxicity against different species, including humans. On other hand, use bacteria bioremediation represents eco-friendly alternative removal xenobiotics. In this study, aim was to isolate identify from agricultural soils determine their ability tolerate biodegrade CYP. Additionally, some metabolites...
Abstract A series of novel 4‐acetyl‐1,3,4‐oxadiazole derivatives was designed and synthesized for their biological evaluation in vitro against Trypanosoma cruzi ( T. ) Leishmania mexicana L. ). Additionally, all compounds were evaluated by molecular docking on the cruzain Tc Cz) cysteine protease B (CPB) Lm CPB) to know potential mechanism binding. Compound OX‐12 had better trypanocidal activity NINOA (IC 50 =10.5 μM) A1 =21.7 strains that reference drug benznidazole =30.3 μM 39.8 μM,...
Phenanthrene is classified as a priority environmental pollutant because of its impact on the environment and human health mutagenic carcinogenic agent. The aim this study was isolated identified new bacteria with capability to degrade phenanthrene from Reynosa, Mexico.