A5068869485- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- T-cell and B-cell Immunology
- Trypanosoma species research and implications
- IL-33, ST2, and ILC Pathways
- Genetic factors in colorectal cancer
- Reproductive System and Pregnancy
- Parasitic Infections and Diagnostics
- HIV Research and Treatment
- Colorectal Cancer Screening and Detection
- Peptidase Inhibition and Analysis
- Nutrition, Genetics, and Disease
- Coconut Research and Applications
- MicroRNA in disease regulation
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Toxoplasma gondii Research Studies
- Consumer Attitudes and Food Labeling
- Food Security and Health in Diverse Populations
- Urticaria and Related Conditions
- Research on Leishmaniasis Studies
- Reproductive tract infections research
Universidad de Costa Rica
2013-2024
Instituto de Investigaciones en Ciencias de la Salud
2014
NYU Langone Health
2008
Yokohama City University Hospital
2008
Yokohama City University
2008
Karolinska Institutet
1989-2003
Memorial Sloan Kettering Cancer Center
1989
Natural killer (NK) cells can spontaneously lyse certain virally infected and transformed cells. However, early in immune responses NK are further activated recruited to tissue sites where they perform effector functions. This process is dependent on cytokines, but it unclear if regulated by cell recognition of susceptible target We show here that infiltration into the peritoneal cavity response tumor controlled major histocompatibility complex (MHC) class I phenotype. Tumor lacking...
Abstract By using mice genomically lacking IFN-γR, IL-12, perforin, and recombination-activating gene-1 (RAG-1), we analyzed the regulation importance of IFN-γ in control infection with Chlamydia pneumoniae. IL-12 participates resistance to C. pneumoniae, probably by regulating protective levels mRNA. In turn, is necessary for increased IL-12p40 mRNA accumulation that occurs lungs during suggesting a positive feedback between these two cytokines. experiments including RAG-1−/−/IFN-γR−/−...
SUMMARY Control of Trypanosoma cruzi infection depends largely upon the production interferon (IFN)-γ. During experimental this cytokine is produced early, mainly by natural killer (NK) cells and later T cells. As NK have been reported to participate in defence against T. cruzi, it importance study regulation cell functions during with parasite. Several innate cytokines regulate activity, among them being (IFN)-α IFN-β (type 1 IFNs) interleukin (IL)-12, which all be involved protection...
Helicobacter pylori colonizes the gastric mucosa and induces chronic inflammation. Using a mouse model of H. pylori-induced gastritis, we evaluated mRNA protein expression levels proinflammatory proangiogenic factors, as well histopathological changes in response to infection. Five- six-week-old female C57BL/6N mice were challenged with SS1 strain. Animals euthanized after 5-, 10-, 20-, 30-, 40- 50-weeks post Angpt1, Angpt2, VegfA, Tnf-α, bacterial colonization, inflammatory lesions...
To determine the association of Helicobacter pylori (H pylori) CagA(+) infection and pro-inflammatory polymorphisms genes interleukin (IL)-1RN IL-1B with risk gastric atrophy peptic ulcers in a dyspeptic population Costa Rica, country high incidence mortality cancer.Seven biopsy specimens, fasting blood sample questionnaire concerning nutritional sociodemographic factors were obtained from 501 consecutive patients who had undergone endoscopy for symptoms. A histopathological diagnosis was...
Resistance to the Leishmaniae is associated with interferon (IFN)‐γ mediated activation of macrophages. In this study, Balb/c mice were infected three Leishmania strains that cause progressively growing cutaneous lesions without obvious dissemination; L. mexicana giving rise rapidly lesions, and (Viannia) panamensis ‐like, which both slowly developing lesions. The rate lesion growth was compared induction early local systemic IFN‐γ responses. All parasite induced increased levels transcripts...
SUMMARY Early immunological activation involves an initial phase of cytokine activity and involvement cell types such as NK cells. Such early immune responses are often decisive in resolution microbial infection. cells reduce parasitaemia enhance survival experimental Trypanosoma cruzi infection, although the nature these protective effects is not well understood. In this study, a detailed analysis innate induction absence presence during first 8 days infection was performed. Following...
Gastric cancer is the second most common associated death cause worldwide. Several factors have been with higher risk to develop gastric cancer, among them genetic predisposition. The p53 gene has a polymorphism located at codon 72. which of several types including cancer. aim this study was determine association p53, 72 polymorphism. and pre-malignant lesions in high-risk population from Costa Rica. genotyping carried out by PCR-RFLP 58 patients, 99 controls 41 individuals classified as...
Infection by Helicobacter pylori is a major risk factor for gastric cancer (GC), the second leading cause of cancer-related death worldwide. Although biomarkers such as pepsinogens (PGs) and soluble urokinase plasminogen activator receptor (suPAR) may have diagnostic and/or prognostic value in patients with GC, their levels be affected H. infection. The aim this study was to investigate association presence antibodies cytotoxin-associated gene A (CagA) plasma PGs suPAR cohort Guatemalan GC...
Helicobacter pylori infects a significant proportion of the world population and it is associated with pathologies which include chronic atrophic gastritis, peptic ulcer, gastric neoplasias such as adenocarcinoma MALT lymphoma. Costa Rica has high prevalence infection an elevated incidence cancer its mortality. The global structure for H. been established using MLST scheme. strains circulating in currently unknown. We characterized geographical origin 24 isolates from Rican patients....
Although the intestinal subtype of gastric cancer (GC) is most prevalent around world, a relatively high prevalence diffuse has been reported in some populations Central American countries, including Guatemala. This study aimed to investigate whether differences exist two GC subtypes main ethnic groups Guatemala, namely Mayan and Mestizo (known as Ladino Guatemala), between whom significant socioeconomic disparities exist, determine there an association with Helicobacter pylori
El cáncer gástrico es la neoplasia más frecuente del tubo digestivo, Guatemala posee altas tasas de incidencia y mortalidad. Helicobacter pylori se ha identificado como un carcinógeno gástrico, especialmente si infección por cepas que expresen factor virulencia CagA, asociado a lesiones atróficas precancerosas. Reportes previos indican el análisis biopsias gástricas en pacientes positivos para H. pylori, muestran incremento expresión activador plasminógeno uroquinasa (uPA) su receptor...
Phosphatidylinositol-specific phospholipase C (PI-PLC) treatment of the human natural killer (NK) target cells Molt-4, Jurkat, and U937 reduced their susceptibility to killing by NK in a dose-dependent fashion. This indicates that cell surface structure, anchored glycosyl-phosphatidylinositol (G-PI) moiety, is important cytotoxicity. In contrast, another common line, K562, remained susceptible after enzyme treatment, suggesting distinct structures are expressed this line. PI-PLC Molt-4 also...
La infección por Helicobacter pylori produce, en algunos pacientes, inflamación crónica el estómago, gastritis atrófica y cáncer gástrico. Los mecanismos moleculares que conducen de la a al son desconocidos. magnitud proceso dependen del tipo cepa H. respuesta hospedero ante infección. Esta inflamatoria está regulada citoquinas, algunas las cuales han sido asociadas con cambios secreción ácido estómago riesgo desarrollar gástrico varias lesiones gástricas precancerosas. Sin embargo, relación...
Introducción: Helicobacter pylori es una bacteria Gram negativa capaz de sobrevivir y multiplicarse en la mucosa gástrica humana. Es el factor más importante desarrollo gastritis atrófica crónica, úlcera péptica, linfoma MALT adenocarcinoma. Se estima que mitad población mundial está infectada con esta bacteria. La baja calidad vida costo económico causados por infección H. son importantes. Existen varios métodos para su diagnóstico, pero algunos invasivos, alto o ambos. Objetivo: Comparar...