A5060265528- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Sports Performance and Training
- Advanced DC-DC Converters
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Winter Sports Injuries and Performance
- Multilevel Inverters and Converters
- Hemodynamic Monitoring and Therapy
- Cardiovascular Function and Risk Factors
- Sports injuries and prevention
- Transplantation: Methods and Outcomes
- Education and Learning Interventions
- Energy Harvesting in Wireless Networks
- Wireless Power Transfer Systems
- Airway Management and Intubation Techniques
- Lower Extremity Biomechanics and Pathologies
- Sports Dynamics and Biomechanics
- Nutrition and Health in Aging
- Acute Kidney Injury Research
- Muscle activation and electromyography studies
- Educational Systems and Policies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Heart Rate Variability and Autonomic Control
- Soft Robotics and Applications
Ulsan College
2016-2025
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Electronics and Telecommunications Research Institute
2014-2024
Chungnam National University
2018-2024
Sungkyunkwan University
2023
CHA Bundang Medical Center
2023
CHA University
2023
Creative Commons
2019
Samsung (South Korea)
2014-2019
Physiologically based pharmacokinetic (PBPK) modeling and simulation is a tool that can help predict the pharmacokinetics of drugs in humans evaluate effects intrinsic (e.g., organ dysfunction, age, genetics) extrinsic drug-drug interactions) factors, alone or combinations, on drug exposure. The use this increasing at all stages development process. This report reviews recent instances PBPK decision-making during regulatory review. examples are Center for Drug Evaluation Research several...
A wide band CMOS LC-tank voltage controlled oscillator (VCO) with small VCO gain ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">KVCO</i> ) variation was developed. For variation, serial capacitor bank added to the parallel array. Implemented in a 0.18 mum RF technology, proposed can be tuned from 4.39 GHz 5.26 less than 9.56%. While consuming 3.5 mA 1.8 V supply, has -113.65 dBc/Hz phase noise at 1 MHz offset carrier.
Background Newly developed atrial fibrillation (AF) in patients who have undergone an esophagectomy increases the incidence of postoperative complications. However, clinical implications AF not been fully elucidated these patients. This retrospective observational study investigated predictors for and effect on mortality esophageal cancer undergoing esophagectomy. Methods evaluated 583 esophagectomy, from January 2005 to April 2012. was defined as newly requiring treatment. The risk factors...
A quasi-resonant (QR) controller with an adaptive frequency reduction scheme has been developed for a flyback converter. While maintaining the valley switching, QR reduces switching lighter load by skipping some valleys to reduce power loss and thereby achieve better light-load efficiency. If cannot detect any due damped oscillation of switch voltage, then is given up nonvalley employed keep reducing load. The proposed implemented in 0.35-μm 700-V BCDMOS process applied 40-W efficiency...
This study aimed to assess the effects of remote ischemic preconditioning (RIPC) on liver function in donors and recipients after living donor transplantation (LDLT).Ischemia reperfusion injury (IRI) is known be associated with graft dysfunction transplantation. RIPC used lessen harmful IRI.A total 148 were randomly assigned (n = 75) control 73) groups. involves 3 cycles 5-minute inflation a blood pressure cuff 200 mm Hg upper arm, followed by deflation. The primary aim was postoperative...
β2-Microglobulin (B2M) has garnered considerable interest as a potential pro-ageing factor, leading to speculation about its involvement in muscle metabolism and the development of sarcopenia, key component ageing phenotypes. To explore this hypothesis, we conducted comprehensive investigation into impact B2M on cellular animal biology, well clinical implications concerning sarcopenia parameters older individuals. In vitro myogenesis was induced mouse C2C12 myoblasts with 2% horse serum. For...
An active power-factor correction (PFC) circuit is presented that employs a newly proposed resistor-free zero-current detection (ZCD). While the conventional ZCD requires either sensing resistor or auxiliary transformer, only one OFF-chip capacitor. The PFC with has been implemented in 0.35-μm BCDMOS process and power factor improved up to 9% from employing ZCD. scheme can be applied any type of switch-mode dc-dc converter.
A dual-mode synchronous rectification (SR) controller supporting both the continuous-conduction mode and discontinuous-conduction is developed to improve power efficiency of a flyback converter. The SR ensures nonoverlapped turning-on primary secondary switches by monitoring voltage level switch. requiring four pins only one external resistor has been implemented in 0.35-μm BCDMOS process applied 50-W converter improved upto 6.8% when employed compared employing conventional controller.
A multiphase synchronous buck converter has been developed, in which the number of switching phases is determined by sensed average load current. The maximum four. dc resistance (DCR) inductor used to detect current, also utilized balance current among multiple phases. instantaneous as well generate pulsewidth modulation (PWM) signal switch inductors. implemented a 0.13-μm BCDMOS process shows 91.1% power efficiency when input voltage 2.8 V, output 1.0 and 2.0 A.
This paper presents a two-phase interleaved critical conduction mode (CRM) power factor correction boost converter with variation-tolerant phase shifter (VTPS), which ensures accurate 180° shift between the two converters. A feedback loop similar to phase-locked controls amount of shifting VTPS. The proposed VTPS has better immunity process, supply, and temperature variations than conventional shifter. 320-W CRM prototype been implemented, while interleaving can be selectively applied...
The performance of soft robots depends in large part on the actuation actuators used to drive them, and those making use fluidic have gained most traction form pneumatic artificial muscles (PAMs). These PAMs make change volume a structure through pressurization their produce mechanical work. However, how this deforms throughout motion. Pouch motors been proposed as lightweight yet powerful actuator, but sealed ends limit performance. This article addition gussets onto pouch gusseted for...
Enhanced sympathetic nervous activation and peripheral vasodilation in end-stage liver disease (ESLD) may limit the importance of left ventricular ejection fraction (LVEF) as an influential prognosticator. We sought to understand LVEF cardiac dimensions ESLD patients order define threshold predict all-cause mortality after transplantation (LT).Data were collected prospectively from Asan LT Registry between 2008 2016, outcomes retrospectively reviewed. LVEF, end-diastolic volume index (EDVI),...
A load-independent current control technique is applied to a single-inductor multiple-output switching dc-dc boost converter implemented in 0.5-μm standard CMOS technology. The total regulated by monitoring the instant of zero inductor current, and no additional power stage reactive components are required. output voltage settles within 25 μs with dip less than 50 mV when load other changes between 0 mA.
We aimed to determine if the severity of computed tomographic coronary angiography (CTCA)–diagnosed artery disease (CAD) is associated with postliver transplantation (LT) myocardial infarction (MI) within 30 days and early mortality. retrospectively evaluated 2118 consecutive patients who underwent CAD screening using CTCA. Post-LT type-2 MI, elicited by oxygen supply-and-demand mismatch a month after LT, was assessed according CTCA-diagnosed CAD. Obstructive (>50% narrowing, 9.2%...
This study presents an electromagnetic design methodology for a rotary magnetorheological (MR) fluid actuator. In order to improve the performance of MR actuator, magnetic field should be effectively applied fluid. Therefore, it is important that circuit composed fluid, ferromagnetic material flux path, and coil well designed. For this purpose, two effective approaches are proposed: one shorten path by removing unnecessary bulk yoke in static characteristic other increase reluctance...
Resonant magnetic coupling is utilized to transfer 3.0-W power without wire. The received AC rectified by an active rectifier and then converted the desired DC level a switching DC-DC converter. reverse leakage of prevented delay locked loop (DLL) based compensation circuit. overall efficiency wireless receiver implemented in 0.35-μm BCDMOS technology 75-% when resonant frequency resonator 3.23-MHz.
The inflammatory response has been shown to be a major contributor acute kidney injury. Considering that laparoscopic surgery is beneficial in reducing the response, we compared incidence of postoperative injury between liver resection and open resection. Among 1173 patients who underwent surgery, 222 926 were matched with 247 resection, by using propensity score analysis. assessed according creatinine criteria Kidney Disease: Improving Global Outcomes definition was those 1:1 groups. A...
Abstract Background & Aims Early allograft dysfunction (EAD) is predictive of poor graft and patient survival following living donor liver transplantation (LDLT). Considering the impact inflammatory response on injury extent LDLT, we investigated association between neutrophil‐to‐lymphocyte ratio (NLR) EAD, 1‐year failure, mortality compared it to C‐reactive protein (CRP), procalcitonin, platelet‐to‐lymphocyte Glasgow prognostic score. Methods A total 1960 consecutive adult LDLT...
A biosimilar is a biological medicinal product that highly similar to an authorized in terms of quality, activity, safety and efficacy. SB5 was developed by Samsung Bioepis as referencing adalimumab, the European Commission (EC) August 2017 (Imraldi®). Extensive characterization studies were performed demonstrate functional similarity reference adalimumab (Humira®, AbbVie Inc. Deutschland GmbH & Co. KG). Humira® showed soluble TNF-α binding neutralizing well transmembrane activity reverse...
Postreperfusion syndrome (PRS) has been shown to be related postoperative morbidity and graft failure in orthotopic liver transplantation. To date, little is known about the impact of PRS on prevalence acute kidney injury (AKI) outcomes after living donor transplantation (LDLT). The purpose our study was determine AKI LDLT surgery.Between January 2008 October 2015, we retrospectively collected evaluated records 1865 patients who underwent surgery. We divided into 2 groups according...