A5088188206- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Alzheimer's disease research and treatments
- Protein Interaction Studies and Fluorescence Analysis
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Photochemistry and Electron Transfer Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Photochromic and Fluorescence Chemistry
- Supramolecular Self-Assembly in Materials
- Nonlinear Optical Materials Studies
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Hemoglobin structure and function
- Porphyrin Metabolism and Disorders
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Plasmonic and Surface Plasmon Research
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Metal-Catalyzed Oxygenation Mechanisms
- X-ray Diffraction in Crystallography
- Parkinson's Disease Mechanisms and Treatments
Taras Shevchenko National University of Kyiv
2014-2025
Institute of Molecular Biology and Genetics
2014-2023
National Academy of Sciences of Ukraine
2007-2019
Kyiv City Clinical Oncology Center
2018
The size dependence of the photoluminescence spectra from silver nanoparticles embedded in a silica host medium was observed. quantum yield increased when decreased. for 8 nm nanoparticle estimated to be on order ${10}^{\ensuremath{-}2}$ which is ${10}^{8}$ times higher than one observed bulk silver. two bands were rationalized as radiative electron interband transitions and decay surface plasmons nanoparticles. strong local electric field induced by surface-plasmon resonance enhances...
Biodistribution of photosensitizer (PS) in photodynamic therapy (PDT) can be assessed by fluorescence imaging that visualizes the accumulation PS malignant tissue prior to PDT. At same time, excitation during an assessment its biodistribution results premature photobleaching and cause toxicity healthy tissues. Combination with a separate fluorescent moiety, which excited apart from activation, provides possibility for (FI) guided delivery cancer site, followed PDT.In this work, we report...
Abstract The spectral luminescent properties of two groups monomethine cyanine dyes were studied in the presence DNA. first group included five with 5,6‐methylenedioxy‐[ d ]‐benzo‐1,3‐thiazole heterocycle and their unsubstituted analogs. Five pyrylium cyanines N ‐methyl‐pyridine analogs second group. In each pair pyridine had similar geometry but differed charge density distribution. results presented some evidence favor half‐intercalation interaction mode between When benzothiazole residue...
Abstract Amyloid fibrils are insoluble protein aggregates whose accumulation in cells and tissues is connected with a range of pathological diseases. We studied the impact 2 metal complexes (axially coordinated Hf phthalocyanine iron (II) clathrochelate) on aggregation insulin lysozyme. For both proteins, host‐guest interaction these compounds changes kinetics fibrillization affects morphology final aggregates. The very efficient inhibitor fibrillization; its presence, only low amounts...
Anomalous temperature dependence of surface plasmon enhanced photoluminescence from copper nanoparticles embedded in a silica host matrix has been observed. The quantum yield increases as the increases. key role such an effect is interplay between resonance and interband transitions occurring at change temperature. Namely, increase leads to red shift resonance. spectral overlap with band well decrease damping caused by transitions. Such mechanisms lead enhancement factor and, consequently,...
An ability of the ribbed-functionalized iron(ii) clathrochelates to induce a CD output in interactions with protein, covalent bonding or supramolecular low-molecular-weight chiral inductor, was discovered. The inactive, carboxyl-terminated serum albumin induced their molecular asymmetry, causing an appearance strong signals range 350-600 nm, whereas methyl ester and amide clathrochelate derivatives remained almost inactive. spectra on (R)-(+)-1-phenylethylamine gave substantially lower than...
Green-emitting water-soluble amino-ketoenole dye AmyGreen is proposed as an efficient fluorescent stain for visualization of bacterial amyloids in biofilms and the detection pathological vitro. This almost non-fluorescent solution, displays strong green emission presence amyloid fibril proteins. also weakly to biomolecules that are components cells, extracellular matrix or medium: nucleic acids, polysaccharides, lipids, Thus, luminescence turn-on behavior can be utilized biofilm matrix....