A5036867163- Porphyrin and Phthalocyanine Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Photodynamic Therapy Research Studies
- Magnetism in coordination complexes
- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Analytical Chemistry and Sensors
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Electrochemical Analysis and Applications
- Porphyrin Metabolism and Disorders
- Metalloenzymes and iron-sulfur proteins
- Click Chemistry and Applications
- Oxidative Organic Chemistry Reactions
- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Computational Drug Discovery Methods
- Molecular Sensors and Ion Detection
- Hemoglobin structure and function
- Protein Interaction Studies and Fluorescence Analysis
- Electrochemical sensors and biosensors
- Synthesis of Organic Compounds
- Supramolecular Chemistry and Complexes
National Academy of Sciences of Ukraine
2011-2024
Palladin Institute of Biochemistry
2000-2024
Institute of General and Inorganic Chemistry
2019-2020
Karpov Institute of Physical Chemistry
2005
A remetalation (a capping group exchange) reaction of the boron−antimony-capped iron(II) clathrochelates with zirconium and hafnium(IV) phthalocyanines in CH2Cl2/CH3OH medium afforded hybrid phthalocyaninoclathrochelates a practically quantitative yield. The complexes obtained have been characterized both on basis elemental analysis, PD mass spectrometry, IR, UV−vis, 57Fe Mössbauer, NMR spectroscopies, crystallographically. An encapsulated ion an intermediate between trigonal-prismatic...
Abstract Amyloid fibrils are insoluble protein aggregates whose accumulation in cells and tissues is connected with a range of pathological diseases. We studied the impact 2 metal complexes (axially coordinated Hf phthalocyanine iron (II) clathrochelate) on aggregation insulin lysozyme. For both proteins, host‐guest interaction these compounds changes kinetics fibrillization affects morphology final aggregates. The very efficient inhibitor fibrillization; its presence, only low amounts...
The reaction with sodium cyanide of the μ-oxo-bridged complex tetra-4-tert-butyl-substituted iron phthalocyanine (form ‘690’) and that product its treatment organic bases such as Py, Im, etc. ‘627’) result in formation same ferrous bis-cyanide Na 2 [ Pc t Fe II ( CN ) ] which can be readily oxidized to analogous ferric III ]. Form ‘690’ has been corresponding μ-oxo ‘630’). Data for all complexes (chemical behavior; electronic, NMR, Mössbauer, X-ray photoelectron ESR spectra; magnetic...
Green-emitting water-soluble amino-ketoenole dye AmyGreen is proposed as an efficient fluorescent stain for visualization of bacterial amyloids in biofilms and the detection pathological vitro. This almost non-fluorescent solution, displays strong green emission presence amyloid fibril proteins. also weakly to biomolecules that are components cells, extracellular matrix or medium: nucleic acids, polysaccharides, lipids, Thus, luminescence turn-on behavior can be utilized biofilm matrix....
Functionalized β-ketoenoles for efficient fluorescence sensing of protein amyloid fibrils giving strong emission increase up to 0.5 QY are designed.
Fourteen Zr IV and Hf phthalocyanines containing different β-diketone axial liangds were characterized in CH 2 Cl 0.1 M TBAP as to their electrochemical spectroelectrochemical properties.No significant difference behavior was seen between the complexes.These compounds exhibit up three oxidations four reductions under given solution conditions HOMO-LUMO gap ranges from 1.56 1.67 V.The changes redox potentials spectra of a function substituents attached on β-ketone ligands evaluated using...
A fluorescein-tagged iron(ii) cage complex was obtained in a moderate total yield using two-step synthetic procedure starting from its propargylamine-containing clathrochelate precursor. An 11-fold decrease fluorescence quantum is observed passing the given fluorescein-based dye to derivative. excitation energy transfer terminal fluorescent group of macrobicyclic molecule quasiaromatic highly π-conjugated framework can explain this effect. The kinetics hydrolysis acetyl groups acetylated...
A series of bisaxially co-ordinated low-spin iron(II) phthalocyanine complexes (pc)FeL2 with different types nitrogen bases as axial ligands has been prepared and characterised by electronic, 1H NMR Mössbauer spectroscopies. The influence electronic steric effects the on quadrupole splitting (ΔEQ) isomer shift (δ), parameters, metal-to-ligand charge transfer (MLCT) band position are discussed. partial (p.q.s.) (p.i.s.) parameters for have estimated rationalised overall data (nx)2FeL2 (nx =...
The mixed-ligand phthalocyanine lanthanide complexes [Ln(pc)X2] [pc = radical anion; Ln Sm, Eu, Gd or Lu; X 1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dionate (fod), 1,1,1-trifluoro-4-phenylbutane-2,4-dionate (btfa) 3-heptafluorobutyryl-D-camphorate (hfbc)] have been synthesized and characterized by electronic, ESR plasma desorption mass spectroscopy as well elemental analysis. Bands in the electronic spectra at 820, 716, 500, 425 330 nm typical for anions observed red initial...
Keywords: amyloid fibril, phthalocyanines, inhibitors of fibril formation, insulin, aggregation fluorescent dye
Abstract Amyloid fibrils are rigid β‐pleated protein aggregates that connected with series of harmful diseases and at the same time promising as base for novel nanomaterials. Thus, design compounds able to inhibit or redirect those formation is important both biomedical aims nanotechnology applications. Here, we studied effect tetraphenylporphyrins (metal free, their Cu Pd complexes, functionalized by carboxy amino groups on periphery) insulin amyloid self‐assembling. The strongest impact...
The electronic structures of a set PcFe(azole) 2 complexes (azole = imidazole, [Formula: see text]-methylimidazole, pyrazole, isoxazole, thiazole, 1,2,4-triazole, 3-amino-1,2,4,-triazole, and 5-amino-1,2,3,4-tetrazole) were examined by Mössbauer spectroscopy Density Functional Theory (DFT) calculations. In addition, the geometric distortions in these compounds elucidated X-ray crystallography for thiazole-containing compounds. Predicted DFT calculations, hyperfine parameters all are...
Amyloid fibrils are widely studied both as target in conformational disorders and basis for the development of protein-based functional materials. The three Zr phthalocyanines bearing dehydroacetic acid residue (PcZr(L1)2) its condensed derivatives (PcZr(L2)2 PcZr(L3)2) out-of-plane ligands were synthesized their influence on insulin fibril formation was by amyloid-sensitive fluorescent dye based assay, scanning electron microscopy, absorption spectroscopies. presence shown to modify...
Water-soluble phthalocyaninato zirconium(IV) and hafnium(IV) complexes have been synthesized for the first time. An increased solubility in comparison to PcZrCl 2 PcHfCl was caused by introduction of gallic, 1,8-dihydroxynaphthalene-3,6-disulfonic (chromotropic), 5-sulfosalicylic acids axial position. The new compounds were characterized 1 H NMR, IR, UV-vis elemental analysis.
The new axially substituted phthalocyanine (pc) complex of zirconium(IV) with citric acid is reported. It has been shown that the replacement two Cl-atoms fragments takes place as result reaction between [ZrCl2(pc)] and acid. [Zr(citrate)2(pc)] was formed. spectroscopic properties synthesized compound in DMSO, RPMI 1640 medium without fetal calf serum (FCS), H2O, buffer (Tris) solutions have described. Antitumor activity this studied. cytostatic observed concentration range 6.1-9.0x10(9)...