A5033275468- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Alzheimer's disease research and treatments
- Supramolecular Self-Assembly in Materials
- Magnetism in coordination complexes
- Crystallization and Solubility Studies
- Analytical Chemistry and Sensors
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Oxidative Organic Chemistry Reactions
- Photochemistry and Electron Transfer Studies
- Computational Drug Discovery Methods
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Porphyrin Metabolism and Disorders
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Electrochemical Analysis and Applications
- Transition Metal Oxide Nanomaterials
- Luminescence and Fluorescent Materials
- Vanadium and Halogenation Chemistry
- Gas Sensing Nanomaterials and Sensors
- Synthesis and Characterization of Heterocyclic Compounds
- Cellular transport and secretion
National Academy of Sciences of Ukraine
2009-2024
Palladin Institute of Biochemistry
2010-2021
Institute of General and Inorganic Chemistry
2020
Functionalized β-ketoenoles for efficient fluorescence sensing of protein amyloid fibrils giving strong emission increase up to 0.5 QY are designed.
Methods for the synthesis of various coordination compounds iron phthalocyanines and their closest structural analogues, viz., porphyrazines naphthalocyanines, structures, properties applications are surveyed. The bibliography includes 230 references.
Keywords: amyloid fibril, phthalocyanines, inhibitors of fibril formation, insulin, aggregation fluorescent dye
Abstract Amyloid fibrils are rigid β‐pleated protein aggregates that connected with series of harmful diseases and at the same time promising as base for novel nanomaterials. Thus, design compounds able to inhibit or redirect those formation is important both biomedical aims nanotechnology applications. Here, we studied effect tetraphenylporphyrins (metal free, their Cu Pd complexes, functionalized by carboxy amino groups on periphery) insulin amyloid self‐assembling. The strongest impact...
Amyloid fibrils are widely studied both as target in conformational disorders and basis for the development of protein-based functional materials. The three Zr phthalocyanines bearing dehydroacetic acid residue (PcZr(L1)2) its condensed derivatives (PcZr(L2)2 PcZr(L3)2) out-of-plane ligands were synthesized their influence on insulin fibril formation was by amyloid-sensitive fluorescent dye based assay, scanning electron microscopy, absorption spectroscopies. presence shown to modify...
Two complexes of bis(aminobenzoato)zirconium(IV) phthalocyanine and their graphite oxide-based composites were synthesized characterized in respect photochemical properties. Structures phthalocyanines confirmed by Mass infrared spectroscopies. The absorption photoluminescence spectra investigated to show various behavior the different media (dimethyl sulfoxide saline). Optical technique (monitoring variation diphenylisobenzofuran used as an indicator) was prove generation reactive oxygen...
Abstract Formation of the deposits protein aggregates—amyloid fibrils in an intracellular and intercellular space—is common to a large group amyloid‐associated disorders. Among approaches develop therapy such disorders is use agents preventing fibrillization. Polyaromatic complexes—porphyrins phthalocyanines—are known as compounds possessing anti‐fibrillogenic activity. Here, we explore impact related macrocyclic complexes—phthalocyanines (Pc) octaphenyl porphyrazines (Pz) Mg Zn—on...
Abstract This article is a part of scientific project focused on obtaining new type composite materials that are characterized by singlet oxygen generation upon irradiation with red light, which can be used as antibacterial agents. The material nanoscale graphite oxide (GO) particles covalently bonded to an axially substituted zirconium phthalocyanine complex. For this purpose, two complexes, mono-substituted 4-aminosalicylic or 4-aminophthalic acids, were prepared and measured in terms...
In this study, a series of condensed derivatives dehydroacetic acid with chalcone structure were synthesized by the Knevenagel reaction using isopropanol as solvent. The yield was 30–75%. It shown that obtained compounds are capable chelating rare earth metals, including La(III) ions. All complexes have distorted three coordinated ligands according to MALDI MS spectral data. presence water molecules in confirmed thermal study such TG and DTA is dehydration hydroxocomplexes occurs at...
The objective of this work was synthesizing Ti-, Zr-, Hf-phthalocyanines, containing chloride ions or dibenzoylmethanate fragments coordinated in out-of-plane positions to macrocycle.Spectroscopic and photophysical parameters phthalocyanines metallocomplexes with metal atoms Ti(IV), Zr(IV) Hf(IV) spectroscopic features Mg-and Zn-phthalocyanines have been detected characterized at ambient liquid nitrogen temperatures.The efficient intersystem crossing observed for Hf-phthalocyanine leads very...