To investigate risk factors for delayed sputum culture conversion to negative during anti-tuberculosis treatment, with an emphasis on smoking.Nested case-control study of adults non-cavitary, culture-confirmed pulmonary tuberculosis (TB) participating in treatment trial Brazil. A case was a patient who remained culture-positive after 2 months treatment. Odds ratios 95% confidence intervals were calculated.Fifty-three cases and 240 control patients analyzed. Smokers had three-fold greater...

Background One of the three main targets World Health Organization (WHO) End TB Strategy (2015-2035) is that no tuberculosis (TB) patients or their households face catastrophic costs (defined as exceeding 20% annual household income) because disease. Our study seeks to determine, a baseline, magnitude and drivers associated with disease for monitor proportion experiencing in Brazil. Methods A national cross-sectional cluster-based survey was conducted Brazil 2019-2021 following WHO...

OBJETIVO: Determinar os principais efeitos adversos causados pelo esquema de tratamento da tuberculose preconizado Ministério Saúde. MÉTODOS: Estudo descritivo e prospectivo envolvendo 79 pacientes com tratados no Centro Pesquisa Clínica do Hospital Universitário Cassiano Antônio Moraes, município Vitória, ES, entre 2003 2006. O regime consistiu em isoniazida, rifampicina, pirazinamida etambutol por quatro meses, seguido rifampicina isoniazida dois meses. Durante o tratamento, foram...

The objective of this study was to compare the costs and outcomes associated with guardian-supervised directly observed treatment relative standard care Directly Observed Therapy, Short Course (DOTS) provided by community health workers (CHW). New cases culture-positive pulmonary tuberculosis (TB) treated in Vitória, Espírito Santo State, Brazil, between January 2005 December 2006 were interviewed chose their preferred strategy. Costs incurred providers patients (and patients' families)...

Chemical and structural modifications in multilayer liposomes of synthetic phosphatidylcholine induced by gamma irradiation are investigated with different techniques. Fluorescence anisotropy the DPH probe differential scanning calorimetry reveal a broadening main lipid transition disappearance pretransition. is shown to be higher irradiated sample particularly so at low temperatures. NMR TLC results show that lysolecithin palmitic acid formed consequent change bilayer organization. The...

To compare tuberculosis cure rates among patients supervised by household members or health care workers.Prospective cohort study of 171 treated the program in Vitoria, Southeastern Brazil, from 2004 to 2007. Each patient was followed-up for six months until end treatment. Of studied, a member 59 and healthcare workers 112 patients. Patients' sociodemographic clinic data were analyzed. Differences between groups assessed using chi-square test Student's t-test. Significance level set at...

To evaluate the impact of catastrophic costs on unfavorable tuberculosis treatment outcomes.This was a prospective cohort study, conducted in five Brazilian state capitals (Manaus, Recife, Vitória, Campo Grande and Porto Alegre) from June 2016 to July 2018. Logistic regression used calculate odds ratio (OR) 95% confidence intervals (95%CI).Of 350 participants, 310 were included, whom 30 presented outcomes. Catastrophic cost (OR=2.53 -95% CI 1.13;5.67) divorce (OR=5.29 1.39;20.05) increased...

NMR relaxation times and of agarose Fricke gels have been measured in the range 17 - 51 MHz. The analysis spin echo curves indicates a multi-exponential behaviour, characterized by three components, at all examined frequencies. relative values, ranging from few to hundred milliseconds, can be attributed different species water molecules present gel. Two these components are rates , more sensitive than gamma irradiation, sensitivity S being . values decrease as function frequency, but no gain...

OBJETIVO: Descrever os fatores associados ao abandono de quimioprofilaxia TB em maiores 15 anos atendidos programas referência controle da doença. MÉTODOS: Realizou-se um estudo coorte histórica com análise prontuários preenchidos entre 2002 e 2007 nos doença no município Vitória (ES). Os casos infecção por Mycobacterium tuberculosis foram estratificados dois grupos- profissionais saúde (grupo PS) indivíduos não NPS). RESULTADOS: Um total 395 foi incluído estudo: 35 grupo PS 360 NPS. A média...

Objective: To evaluate the implications of proportion annual family income spent in pre- and post-diagnosis periods tuberculosis patients followed for after at least one year completing treatment Brazil. Methods: This was a cross-sectional study five Brazilian capitals (one each region country). Results: A total 62 were included analysis. The overall average cost 283.84 reals (R$) pre-diagnosis period R$4,161.86 period. After costs disease, 71% became unemployed, with an increase...

Resumo Objetivo avaliar o impacto econômico domiciliar do adoecimento pela tuberculose no Brasil. Método pesquisa transversal multicêntrica de 2016 a 2018, em cinco capitais Brasil, pacientes diagnosticados com tuberculose. Os custos totais foram soma dos diretos e indiretos incorridos antes durante diagnóstico tratamento. A regressão logística foi utilizada para estudar determinantes catastróficos. pobreza medida como renda familiar per capita diária < U$ 5,5. Resultados trezentos...

In Fricke-agarose gels, an accurate determination of the spatial dose distribution is hindered by diffusion ferric ions. this work, a model was developed to describe process within gel samples finite length and, thus, permit reconstruction initial The temporal evolution ion concentration as function derived solving Fick's second law in two dimensions with boundary reflections. applied magnetic resonance imaging data acquired at high resolution (0.3 mm) and found accurately observed effects.

Structural changes induced by the fat‐soluble vitamins A, D 3 , E and K 1 in natural membranes were studied 31 P NMR fluorescence anisotropy on erythrocyte ghosts; occurrence of cell fusion following vitamin addition was detected optical microscopy intact cells. Vitamins which produce fusion, also induce formation configurational phases other than bilayer increase, at a different extent for vitamins, membrane fluidity. Vitamin contrary, induces aggregation without paralleled phase...

SummaryAn investigation of the structural and thermodynamical modifications induced by γ-irradiation in model membranes is reported. Differential scanning calorimetry X-ray diffraction were used to study different phases associated transitions distearoylphosphatidylcholine multilamellar liposomes after 60Co γ-irradiation. Changes observed shape calorimetric peaks corresponding phase transition temperatures. In particular a shoulder was at about 20 kGy. The three characteristic lecithins with...

Abstract Introduction: Tuberculosis is historically associated with poverty, generating costs that can influence treatment. Considering the impact of illness, importance adapting instrument highlighted. Objective: To adapt transculturally to Brazilian Portuguese Tool Estimate Patient's Costs. Methods: Study type transcultural adaptation instrument. The translation followed criteria described by Herdman, 1998, in order preserve functional equivalence as much possible. questionnaire...

Abstract A modified Prony method (MPM) was applied to analyze the main signals present in spatially resolved 31 P NMR spectra of MCF7 breast tumors implanted nude mice. First, tested on synthetic data establish its limits reliability. Its performance with respect peak identification and quantification signal intensities then exploited from three during hormonal manipulation estrogen antiestrogenic drug tamoxifen. The phosphomonoester into phosphocholine (PC) phosphoethanolamine (PE)....

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Fricke-agarose gels have elicited much interest in the field of radiation dosimetry, as tissue-equivalent dosemeters. magnetic resonance (MR) relaxation rates are measured for dose reconstruction. A major problem is diffusion ferric ions formed after irradiation. Knowledge coefficient may be necessary. Xylene orange, a dye that specifically chelates ions, was added to Fricke gel system reduce ion and, binding gives coloured complex, allow optical detection ions. Diffusion two dimensions and...

Objective: To compare, on the basis of clinical, radiological and epidemiological aspects, all cases tuberculosis (TB) diagnosed in tertiary healthcare services to those at primary providers municipality Vitoria-ES. Methods: Cross- sectional, retrospective study, with analysis SINAN’s database, identify among residents Vitoria-ES TB 2006 2007. Patients were divided into two groups: Primary Health Care (PHC) Tertiary (THC). For statistical analysis, it was used software STATA CORP 9.0....