A5007621976- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Insects and Parasite Interactions
- HIV/AIDS Research and Interventions
- Allergic Rhinitis and Sensitization
- Helminth infection and control
- Adipose Tissue and Metabolism
- Planarian Biology and Electrostimulation
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Lymphatic System and Diseases
- Insect symbiosis and bacterial influences
- Muscle metabolism and nutrition
- Dermatological diseases and infestations
- Women's cancer prevention and management
- Male Reproductive Health Studies
- Exercise and Physiological Responses
- Child Nutrition and Water Access
- Global Maternal and Child Health
Universidade Positivo
2024
Ministerio de Salud Pública
2010-2018
University of Pennsylvania
2018
Centro Nacional de Epidemiología
2018
University of South Dakota
2010
Instituto Nacional de Investigación en Salud Pública
2007
Hospital Vozandes
1997-2001
Summary Background The low prevalence of allergic disease in the rural tropics has been attributed to protective effects chronic helminth infections. There is concern that treatment‐based control programmes for these parasites may lead an increase diseases. Objective We measured impact 15–17 years anthelmintic treatment with ivermectin on allergen skin test reactivity and symptoms school‐age children. Methods reactivity, exercise‐induced bronchospasm was compared between children living...
Control of soil-transmitted helminth (STH) infections relies on the periodic and long-term administration anthelmintic drugs to high-risk groups, particularly school-age children living in endemic areas. There is limited data effectiveness treatment prevalence STHs, from operational programmes. The current study investigated impact 15 17 years with broad-spectrum ivermectin, used for control onchocerciasis, STH intensity pre-school children.A cross-sectional was conducted communities that...
Objective The estimation of prevalence and intensity soil-transmitted helminth (STH) infections at a country-level is an essential prerequisite for the implementation rational control programme. aim this present study was to estimate distribution STH malnutrition in school-age children rural areas Ecuador. Design Cross-sectional from October 2011 May 2012. Setting Eighteen schools were randomly selected three ecological regions Ecuador (coastal, highlands Amazon basin). Participants 920 aged...
A clinically significant endemic focus of onchocerciasis existing in Esmeraldas Province, coastal Ecuador has been under an ivermectin mass drug administration program since 1991. The main transmitting vector this area is the voracious blackfly, Simulium exiguum. This paper describes assessments made that support decision to cease treatment.Thirty-five rounds treatment occurred between 1991-2009 with 29 these carrying >85% coverage. Following guidelines set by WHO for ceasing distribution...
The immune response after early exposure to or infection with Onchocerca volvulus was investigated in an autochthonous focus caused by the migration of infected persons a previously unaffected area Ecuador. Peripheral blood mononuclear cell (PBMC) proliferative and cytokine responses (interferon [IFN]–γ interleukin [IL]–5) filarial antigens were measured 14 subjects serologic evidence 7 dermal microfilarial DNA compared 43 chronic O. infections. PBMC (IFN-γ IL-5) parasite elevated...
Abstract Background Onchocerciasis is a leading cause of blindness worldwide, hence elimination the infection an important health priority. Community-based treatment programs with ivermectin form basis control for disease in Latin America. The long-term administration could eliminate Onchocerca volvulus from endemic areas Methods A strategy annual to twice-annual treatments has been used onchocerciasis communities Ecuador up 14 years. impact on ocular morbidity, and O. transmission was...
The Esmeraldas focus of onchocerciasis in Ecuador expanded geographically during the 1980s and was associated with severe ocular skin disease. Mass drug administration (MDA) ivermectin started 1991, initially once but later twice a year, principle endemic followed by all satellite foci. Treatment stopped 2009 when entomological assessments determined that transmission Onchocerca volvulus had been interrupted. Three years after cessation treatment 2012, as defined WHO guidelines for...
Immunocytochemical examination of onchocercal nodule tissues containing adult Onchocerca volvulus using immuno-markers for blood and lymphatic vessels (vWF, D2-40, podoplanin, Prox-1, Lyve1) shows a distinct pattern distribution these within nodules. Blood were commonly seen associated with organized lymphoid cellular aggregates in the both outer inner areas In contrast, majority vessel positivity was central zone close apposition to parasites, remainder usually microfilariae nodule. These...
A retrospective study was performed comparing the number of spontaneous abortions in a hyperendemic area for onchocerciasis Ecuador before and after invermectin treatment with that comparable non-endemic area. The frequency associated change community microfilarial load, suggesting there may be relationship between infection Onchocerca volvulus. In endemic area, significantly greater rate seen period ivermectin distribution compared to start treatments every 6 months. no over same time...
Introduction: Premenstrual Dysphoric Disorder (PMDD) is a severe form of Syndrome (PMS) characterized by psychological or behavioral symptoms that significantly impact woman’s quality life. Due to its recent recognition as mental health disorder, many healthcare professionals remain unfamiliar with PMDD, complicating diagnosis and management. Objective: To evaluate the perception medical students in Curitiba, Paraná, regarding premenstrualdysphoric disorder. Methods: This descriptive...
Control and elimination of filarial pathogens is a central focus major global health efforts directed at parasitic diseases developing countries. Accomplishment these goals would be markedly enhanced by the destruction adult stage filariae. The identification new, more quantitative biomarkers that correlate with mortality or chemotherapeutic damage to filariae, greatly facilitate, for example, development new macrofilaricides. An immunocytochemical approach using an antibody against human...