A5071336899- Parasitic Diseases Research and Treatment
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Insects and Parasite Interactions
- Mosquito-borne diseases and control
- Lymphatic System and Diseases
- Insect symbiosis and bacterial influences
- Dermatological diseases and infestations
- Malaria Research and Control
- Planarian Biology and Electrostimulation
- Mobile Health and mHealth Applications
- Diagnosis and Treatment of Venous Diseases
- Bird parasitology and diseases
- Cultural Competency in Health Care
- COVID-19 epidemiological studies
- Blood Pressure and Hypertension Studies
- Tendon Structure and Treatment
- Coccidia and coccidiosis research
- Effects of Environmental Stressors on Livestock
- Cancer Treatment and Pharmacology
- Zoonotic diseases and public health
- Lower Extremity Biomechanics and Pathologies
- Telemedicine and Telehealth Implementation
- Toxoplasma gondii Research Studies
- Research on Leishmaniasis Studies
The Task Force for Global Health
2017-2024
Liverpool School of Tropical Medicine
2014-2024
Michigan State University
2002-2018
Michigan United
2014-2017
Western Michigan University
2003-2014
Imaging Center
2003
The pathogenesis of fatal cerebral malaria (CM) is not well understood, in part because data from patients whom a clinical diagnosis was established prior to death are rare. In murine CM model, platelets accumulate brain microvasculature, and antiplatelet therapy can improve outcome. We determined whether also found vessels human CM, we performed immunohistopathology for platelet-specific glycoprotein, GPIIb-IIIa, on tissue multiple sites Malawian children whose illness severe malarial...
Neglected Tropical Diseases (NTDs) afflict around one billion individuals in the poorest parts of world with many more at risk. Lymphatic filariasis is most prevalent infections and causes significant morbidity those who suffer clinical conditions, particularly lymphedema hydrocele. Depressive illness has been recognised as a disability disease because stigmatising nature condition. No estimates burden depressive any neglected tropical have undertaken to date despite recognition that such...
A clinically significant endemic focus of onchocerciasis existing in Esmeraldas Province, coastal Ecuador has been under an ivermectin mass drug administration program since 1991. The main transmitting vector this area is the voracious blackfly, Simulium exiguum. This paper describes assessments made that support decision to cease treatment.Thirty-five rounds treatment occurred between 1991-2009 with 29 these carrying >85% coverage. Following guidelines set by WHO for ceasing distribution...
Lymphatic filariasis (LF) is a parasitic disease transmitted by mosquitoes, causing severe pain, disfiguring, and disabling clinical conditions such as lymphoedema hydrocoele. LF global public health problem affecting 72 countries, primarily in Africa Asia. Since 2000, the World Health Organization (WHO) has led Global Programme to Eliminate Filariasis (GPELF) support all endemic regions. This paper focuses on achievements of Malawi Elimination between 2000 2020 eliminate problem, making it...
Background Lymphatic filariasis (LF) is best known for the disabling and disfiguring clinical conditions that infected patients can develop; providing care these individuals a major goal of Global Programme to Eliminate LF. Methods locating patients, knowing their true number thus them, remains challenge national medical systems, particularly when endemic zone large urban area. Methodology/Principle findings A health community-led door-to-door survey approach using SMS reporting tool...
Abstract Background As new lymphatic filariasis infections are eliminated through mass chemotherapy, previously affected individuals left with the sequellae, especially chronic progressive lymphoedema. Currently this is managed by careful attention to limb hygiene prevent infection. Studies over past 15 years have suggested that incorporation of doxycycline treatment may arrest or even reverse progression Most work has been observational based on small studies, and if intervention effective,...
Background Bangladesh had one of the highest burdens lymphatic filariasis (LF) at start Global Programme to Eliminate Lymphatic Filariasis (GPELF) with an estimated 70 million people risk infection across 34 districts. In total 19 districts required mass drug administration (MDA) interrupt transmission, and 15 were considered low endemic. Since 2001, National LF has implemented MDA, reduced prevalence, been able scale up WHO standard Transmission Assessment Survey (TAS) all endemic as part...
Background Onchocerciasis transmission across international borders is not uncommon, yet a coordinated cross border stops mass drug administration (MDA) decision has been documented. Methods/Principle findings The Galabat-Metema focus involves neighboring districts on the between Sudan and Ethiopia. Mass was provided once subsequently twice per year in this focus, with twice-per-year beginning Ethiopia's Metema subfocus 2016 Sudan's Galabat 2008. Ov16 ELISA-based serosurveys were conducted...
Lymphedema (LE) is one the most disfiguring chronic manifestations of lymphatic filariasis. Its management relies primarily on limb hygiene and local care. A previous study in Ghana demonstrating a beneficial effect doxycycline LE led to current multicenter trial efficacy filarial LE. randomized placebo-controlled was initiated two rural health districts Mali. Patients with stages 1-3 were receive either (200 mg/day) or placebo over 6-week monitored treatment period then followed every 6...
Lymphedema, hydrocele, and acute adenolymphangitis (ADL) are chronically disabling consequences in patients with lymphatic filariasis (LF). Provision of morbidity management disability prevention concurrent mass drug administration anthelmintics two pillars for elimination LF. This study assessed the impact strict hygiene protocols or without doxycycline on progression filarial lymphedema. A randomized, placebo-controlled, double-blind trial was conducted regions Tanzania. We enrolled 362...
Filarial lymphedema (LE) remains a significant global problem despite the progress made toward elimination of lymphatic filariasis (LF). In Ghana, main approach to LF is preventive chemotherapy, but this has minimal impact on individuals who have already developed LE. 2018-2020, 24-month randomized, double-blind, placebo-controlled trial was conducted evaluate efficacy stringent hygiene measures using Essential Package Care with or without additional administration doxycycline (DOX) improve...
The objective of this study was to examine nodules from Mexico, Guatemala, and Ecuador collected over a one-year period (2001) determine the effects semi-annual ivermectin treatments on Onchocerca volvulus macrofilarial populations. Nodules were sectioned, stained with hematoxylin eosin, histologic findings compared between countries historical data prior introduction into region. had 10 times more dead or moribund worms than control (66.6% versus 6.5%); patients Mexico Guatemala did not...
Background Lymphatic filariasis (LF) is a mosquito-borne parasitic infection that causes significant disabling and disfiguring clinical manifestations. Hydrocoele (scrotal swelling) the most common condition, which affects an estimated 25 million men globally. The recommended strategy surgical intervention, yet little known about impact of hydrocoele on men's lives, how it may change if they have access to surgery. Methodology/Principal findings We prospectively recruited followed-up who...
Abstract Clinical lymphatic filariasis (LF) is a debilitating, disfiguring medical condition with severe psychosocial consequences for patients and their families. Addressing these patients’ needs major component of the global programme to eliminate (GPELF). In 20 y providing minimal package care many thousands surgical operations correct LF hydrocoeles been performed national programmes in >90% endemic countries have received training needed patients. The creation educational...
The induction of pathological changes in Onchocerca volvulus infections is directly related to the presence microfilarial stage this filarial nematode. Patients with either 2 major forms clinical disease (i.e., asymptomatic/mild [n=12] and severe [n=16] dermatopathology) were studied. cellular immune responses (cell proliferation) those stronger (stimulation index [SI], 12.3±1.9) than mild dermatopathological effects (SI, 2.9±0.6) or control patients 4.5±0.4). Cytoadherence antibody greatest...
The defining images of lymphatic filariasis are the horrendous disfigurements lymphoedema, elephantiasis and hydrocele. These clinical presentations, although obviously important life changing, not, however, only outcomes this wide-spread filarial infection. other effects disease range from severe, acute but short-term bouts sickness to psychological impairment, poverty family hardship. It is support cases through all means available, such as reparative hydrocelectomy, hygiene training...
The onchocerciasis focus in Yemen has been known for many years as an endemic area with unique characteristics, notably the atypical and most severe form of onchodermatitis, sowda or reactive onchodermatitis (ROD). national effort to control disease began 1992 individual case treatment program by administering ivermectin those presenting ROD. challenging geography current political military unrest both underscore a need special approaches when attempting eliminate from this country. An...
Fourteen miniature donkeys (Equus asinus) in a mid-Michigan herd of 38 animals presented with clinical signs besnoitiosis, including the presence typical tissue cysts ocular sclera, buccal and nasal mucosa, together characteristic dermatitis specific areas body. The common histopathological change seen was many 100-200-microm diameter, thick walled, Besnoitia sp. chronic cellular response associated degenerating cysts. Microscopy isolated scleral skin biopsies showed protozoal organisms...
The nematodes Wuchereria bancrofti and Brugia spp. infect over 120 million people worldwide, causing lymphedema, elephantiasis hydrocele, collectively known as lymphatic filariasis. Most infected individuals appear to be asymptomatic, but many exhibit sub-clinical manifestations including the lymphangiectasia that likely contributes development of lymphedema elephantiasis. As adult worm excretory-secretory products (ES) do not directly activate endothelial cells (LEC), we investigated role...
Mupanomunda, Maria, Jeffrey F. Williams, Charles D. Mackenzie, and Lana Kaiser. Dirofilaria immitis:heartworm infection alters pulmonary artery endothelial cell behavior. J. Appl. Physiol. 82(2): 389–398, 1997.—The pathogenesis of filariasis has generally been attributed to either physical presence the adult parasites or host’s immune response parasites. However, spectrum cannot be entirely explained by these causes, other mechanisms must operative. It is now evident that factors released...
A prospective study was carried out in an area of unstable malaria transmission central Sudan to determine the efficacy and toxicity quinine pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum at mean 28.8 weeks gestational age were treated for 7 days. The body temperature on presentation 3 patients who delivered prematurely significantly higher than those term (39.2 +/- 0.7 degrees C versus 38.7 1.3 C). There no significant difference between 2 groups other clinical or...