A5077366373- Parasitic Diseases Research and Treatment
- Rabies epidemiology and control
- Venomous Animal Envenomation and Studies
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Malaria Research and Control
- Parasite Biology and Host Interactions
- Yersinia bacterium, plague, ectoparasites research
- Viral Infections and Outbreaks Research
- Insects and Parasite Interactions
- COVID-19 epidemiological studies
- Insect Pest Control Strategies
- Insect Resistance and Genetics
- Zoonotic diseases and public health
- Amphibian and Reptile Biology
- Global Maternal and Child Health
- Child Nutrition and Water Access
Liverpool School of Tropical Medicine
2011-2025
Background The prevalence of Wuchereria bancrofti, which causes lymphatic filariasis (LF) in Gambia was among the highest Africa 1950s. However, surveys conducted 1975 and 1976 revealed a dramatic decline LF endemicity absence mass drug administration (MDA). partly attributed to significant reduction mosquito density through widespread use insecticidal nets. Based on findings elsewhere that vector control alone can interrupt LF, we asked question 2013 whether rapid scale up nets had...
Significance Emerging insecticide resistance in malaria vectors could presage a catastrophic rebound morbidity and mortality. In areas of moderate levels to pyrethroids, long-lasting insecticidal nets (LLINs) indoor residual spraying (IRS) with carbamate were significantly more effective than IRS pyrethroid insecticide. The impact on the effectiveness LLINs not be quantified. incremental cost using which are susceptible was US $0.65 per person protected year, is considered acceptable by...
Lymphatic filariasis (LF) is a parasitic disease transmitted by mosquitoes, causing severe pain, disfiguring, and disabling clinical conditions such as lymphoedema hydrocoele. LF global public health problem affecting 72 countries, primarily in Africa Asia. Since 2000, the World Health Organization (WHO) has led Global Programme to Eliminate Filariasis (GPELF) support all endemic regions. This paper focuses on achievements of Malawi Elimination between 2000 2020 eliminate problem, making it...
A considerable number of patients present to hospitals in Eswatini each year following bites by venomous snakes. Effectively diagnosing and treating with snakebite envenoming requires healthcare workers have a variety generic snakebite-specific medical skills. In several countries, however, been found limited skills managing patients. We used the Delphi method adapt Hennessy-Hicks training needs analysis questionnaire context subsequently adapted assess self-perceived 90 from ten Eswatini....
Background Lymphatic filariasis (LF) is targeted for elimination through annual mass drug administration (MDA) 4–6 years. In 2006, Zanzibar stopped MDA against LF after five rounds of revealed no microfilaraemic individuals during surveys at selected sentinel sites. We asked the question if transmission was truly interrupted in 2006 when stopped. Methodology/Principal Findings line with ongoing efforts to shrink map, we performed WHO recommended assessment (TAS) January 2012 verify absence...
The Democratic Republic of Congo (DRC) has a significant burden lymphatic filariasis (LF) caused by the parasite Wuchereria bancrofti. A major impediment to expansion LF elimination programme is risk serious adverse events (SAEs) associated with use ivermectin in areas co-endemic for onchocerciasis and loiasis. It important analyse these other factors, such as soil transmitted helminths (STH) malaria co-endemicity, which will impact on elimination. We analysed maps community-directed...
The cornerstone of current schistosomiasis control programmes is delivery praziquantel to at-risk populations. Such preventive chemotherapy requires accurate information on the geographic distribution infection, yet performance alternative survey designs for estimating prevalence and converting this into treatment decisions has not been thoroughly evaluated.We used baseline mapping surveys from three countries (Malawi, Côte d'Ivoire Liberia) generate spatially realistic gold standard...
Long-lasting insecticidal nets (LLINs) (with pyrethroids) and indoor residual spraying (IRS) are the cornerstones of Sudanese malaria control program. Insecticide resistance to principal insecticides in LLINs IRS is a major concern. This study was designed monitor insecticide Anopheles arabiensis from 140 clusters four malaria-endemic areas Sudan 2011 2014. All received LLINs, while half (n = 70), distributed across regions, had additional campaigns. gambiae (s.l.) mosquitoes were identified...
Background Halving snakebite morbidity and mortality by 2030 requires countries to develop both prevention treatment strategies. The paucity of data on the global incidence severity envenoming causes challenges in prioritizing mobilising resources for treatment. In line with World Health Organisation’s 2019 Snakebite Strategy, this study sought investigate Eswatini’s epidemiology outcomes, identify socio-geographical factors associated risk. Methodology Programmatic from Ministry Health,...
Lymphatic filariasis (LF) is a mosquito-borne disease, broadly endemic in Zambia, and targeted for elimination by mass drug administration (MDA) of albendazole diethylcarbamazine citrate (DEC) to at-risk populations. Anopheline mosquitoes are primary vectors LF Africa, it possible that the significant scale-up malaria vector control over past decade may have also impacted transmission, contributed decrease prevalence Zambia. We therefore aimed examine putative association between decreasing...
Snakebite is a major public health concern in Eswatini, where treatment relies upon one antivenom-SAIMR Polyvalent. Although effective treating snakebite, SAIMR Polyvalent difficult to source outside its manufacturing country (South Africa) and dauntingly expensive. We compared the preclinical venom-neutralising efficacy of two alternative antivenoms with that against lethal tissue-destructive effects venoms from five species medically important snakes using vivo murine assays. The test were...
It is widely known that the recent Ebola Virus Disease (EVD) in West Africa caused a serious disruption to national health system, with many of ongoing disease focused programmes, such as mass drug administration (MDA) for onchocerciasis (ONC), lymphatic filariasis (LF) and schistosomiasis (SCH), being suspended or scaled-down. As these MDA programmes attempt restart post-EVD it important understand challenges may be encountered. This commentary addresses opinions major sectors involved,...
Abstract Background Snakebite is a major public health concern in Eswatini, where treatment relies upon one antivenom – SAIMR Polyvalent. Although effective treating snakebite, Polyvalent difficult to source outside its manufacturing country (South Africa) and dauntingly expensive. We compared the preclinical venom-neutralising efficacy of two alternative antivenoms against lethal tissue-destructive effects venoms from five species medically important snakes using vivo murine assays. The...
Snakebite envenoming is a debilitating neglected tropical disease disproportionately affecting the rural poor in low and middle-income countries tropics sub-tropics. Critical questions gaps public health policy need to be addressed if major progress made towards reducing negative impact of snakebite, particularly World Health Organisation (WHO) Africa region. We engaged key stakeholders identify barriers evidence-based snakebite decision making explore how development research hubs could...