A5000029644- Malaria Research and Control
- Parasitic Diseases Research and Treatment
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Computational Drug Discovery Methods
- Digital Imaging for Blood Diseases
- Lymphatic System and Diseases
- Mobile Health and mHealth Applications
- Parasite Biology and Host Interactions
- Viral Infections and Outbreaks Research
- Clinical Laboratory Practices and Quality Control
- Insects and Parasite Interactions
- Drug Transport and Resistance Mechanisms
- Trypanosoma species research and implications
- Mollusks and Parasites Studies
- FinTech, Crowdfunding, Digital Finance
- Research Data Management Practices
- Pharmacological Effects and Toxicity Studies
National Institute for Medical Research
2011-2024
Kilimanjaro Christian Medical Centre
2018
Abstract Background Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle the control of malaria. In 2001 Tanzania replaced chloroquine (CQ) with sulphadoxine-pyrimethamine (SP) as first-line drug, which in turn was by artemisinin combination therapy 2006. SP has however, continued be used intermittent preventive treatment malaria pregnancy (IPTp) despite reports high levels due lack alternatives for IPTp. Recent have indicated recovery CQ-susceptibility Malawi,...
In 2006, the first-line anti-malarial drug treatment in Tanzania was changed from sulphadoxine-pyrimethamine (SP) to artemether-lumefantrine (ALu), an artemisinin-based combination (ACT), since when use of SP has been restricted for intermittent preventive pregnancy (IPTp). A number Plasmodium falciparum mutations are known be associated with resistance SP, but it is not if prevalence these increasing or decreasing under conditions reduced levels use. This study reports on current resistant...
Resistance to anti-malarials is a major public health problem worldwide. After deployment of artemisinin-based combination therapy (ACT) there have been reports reduced sensitivity ACT by malaria parasites in South-East Asia. In Tanzania, artemether-lumefantrine (ALu) the recommended first-line drug treatment uncomplicated malaria. This study surveyed distribution Plasmodium falciparum multidrug resistance protein-1 single nucleotide polymorphisms (SNPs) associated with increased parasite...
Lymphedema, hydrocele, and acute adenolymphangitis (ADL) are chronically disabling consequences in patients with lymphatic filariasis (LF). Provision of morbidity management disability prevention concurrent mass drug administration anthelmintics two pillars for elimination LF. This study assessed the impact strict hygiene protocols or without doxycycline on progression filarial lymphedema. A randomized, placebo-controlled, double-blind trial was conducted regions Tanzania. We enrolled 362...
Filarial lymphedema (LE) remains a significant global problem despite the progress made toward elimination of lymphatic filariasis (LF). In Ghana, main approach to LF is preventive chemotherapy, but this has minimal impact on individuals who have already developed LE. 2018-2020, 24-month randomized, double-blind, placebo-controlled trial was conducted evaluate efficacy stringent hygiene measures using Essential Package Care with or without additional administration doxycycline (DOX) improve...
Malaria remains as an important public health and a major cause of childhood death paediatric hospital admission in sub-Saharan Africa. This prospective based cross sectional study was conducted from April 2007 to 2008. The main objective assess clinical manifestations outcomes severe malaria children admitted district Rungwe Kyela south-western Tanzania. A total 1371 were selected screening group which 409 (29.8%) tested positive for malaria. Mean age the 2.7 (95%CI= 2.5, 2.8) years...
Although microscopy is a standard diagnostic tool for malaria and the gold standard, it infrequently used because of unavailability laboratory facilities absence skilled readers in poor resource settings. Malaria rapid tests (RDT) are currently instead or as an adjunct to microscopy. However, at very low parasitaemia (usually < 100 asexual parasites/µl), test line on can be faint consequently hard visualize this may potentially affect interpretation results. Fio Corporation (Canada),...
Background Lymphatic filariasis is a mosquito transmitted parasitic infection in tropical regions. Annual mass treatment with ivermectin and albendazole used for transmission control of Wuchereria bancrofti , the infective agent lymphatic many African countries, including Tanzania. Methodology In general population study Southwest Tanzania, individuals were tested circulating filarial antigen, an indicator W . adult worm burden 2009 before drug administration commenced that area. Seven...
Background: Despite a decrease in malaria burden reported between 2000 and 2015, an increasing trend of transmission has been recently some endemic countries including Tanzania. Periodic monitoring to identify pocket areas for asymptomatic Plasmodium falciparum infection is vital elimination efforts. The objective this study was determine prevalence infections among military recruits selected camps Tanzania.
 Methods: A cross-sectional conducted 2015 at four (Bulombora, Mgambo, Ruvu,...
Globally, there is recognition of the value using mobile phones among health providers in improving systems performance. However, many Low- and Middle-income countries where shortage providers, Community Health Workers have assumed some responsibilities especially relating to identifying reporting on problems within their communities. Despite known benefits phone technology deliver services, limited information extent which are able effectively use data collection reporting. The aim this...
Internal and external quality control (QC) of rapid diagnostic tests (RDTs) is important to increase reliability RDTs currently used diagnose malaria. However, cross-checking as part assurance can rarely be done by off-site personnel because there no guarantee retaining visible test lines after manufacturers' recommended reading time. Therefore, this study examined the potential using Fionet™ technology for remote RDT monitoring at seven clinics, identifying reasons making processing...
Chronic lymphedema caused by infection of Wuchereria bancrofti is a disfiguring disease that leads to physical disability, stigmatization, and reduced quality life. The edematous changes occur mainly on the lower extremities can progress over time due secondary bacterial infections. In this study, we characterized participants with filarial from Ghana Tanzania as having low (stage 1-2), intermediate 3-4), or advanced 5-7) determine CD4+ T cell activation patterns markers associated immune...
There are currently 11–13 foci of human onchocerciasis recognised in Tanzania (Raybould and White, 1979; Maegga, 1991). The disease was first recorded the country by Fischer (1932), from Rungwe (within modern-day Tukuyu focus). Nine years later Gabathuler (1947), Ulanga district, what is now known as Mahenge focus. It not until 1957 that a third focus discovered Tanzania, eastern block Usambara mountains (in Tanga region), Mario Giaquinto-Mira (Woodman, 1958). Another found 1964, western...
<sec> <title>BACKGROUND</title> Digital platforms play a vital role in improving the availability and access to health research outputs enhancing engagement of policymakers practitioners processes. Despite its potential, it needs be explored how digital are utilised manage share datasets publications for translating findings among networks or institutions Sub-Saharan Africa (SSA). </sec> <title>OBJECTIVE</title> To explore experiences sharing data using researchers three large innovation SSA...
Abstract Objective Good quality microscopy is critical for accurate detection and confirmation of malaria parasite infections. Microscopy relies on the skills technicians to prepare read slides, high reagents, a good program internal external control (EQA), which are lacking in most endemic settings. This study was undertaken between January 2016 December 2018 pilot an EQA improved diagnosis patient care Tanzanian Military health facilities. Results Of all blood smears crosschecked (n =...
Abstract Background Globally, there is recognition of the value using mobile phones among health providers in improving systems performance. However, many Low- and Middle-income countries where shortage providers, Community Health Workers have assumed some responsibilities especially relating to identifying reporting on problems within their communities. Despite known benefits phone technology deliver services, limited information extent which are able effectively use data collection...