A5036206978- Food Chemistry and Fat Analysis
- Proteins in Food Systems
- Polysaccharides Composition and Applications
- Supramolecular Self-Assembly in Materials
- Advanced Drug Delivery Systems
- Surfactants and Colloidal Systems
- Hydrogels: synthesis, properties, applications
- Liquid Crystal Research Advancements
- Advancements in Transdermal Drug Delivery
- Influenza Virus Research Studies
- Malaria Research and Control
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Reproductive tract infections research
- Drug-Induced Hepatotoxicity and Protection
- biodegradable polymer synthesis and properties
- Ocular Surface and Contact Lens
- Mosquito-borne diseases and control
- Respiratory viral infections research
- Gut microbiota and health
- Bacterial Infections and Vaccines
- Urinary Tract Infections Management
- Virology and Viral Diseases
- Nanocomposite Films for Food Packaging
- Inhalation and Respiratory Drug Delivery
National Institute of Malaria Research
2024
Delhi Skill and Entrepreneurship University
2024
Directorate General of Training
2024
Panacea Biotec (India)
2017-2018
National Institute of Technology Rourkela
2011-2017
A large women population of the world is suffering from a vaginal infection commonly known as bacterial vaginosis. The disease associated with decrease in lactobacilli count vagina. Till date, there lack full proof treatment modalities for cure disease. includes use antimicrobials and/or acidifying agents and probiotics, either separately or combination. This note discusses about etiology various present-day
The current study explores the properties of starch and non‐starch polysaccharides based bigels containing sunflower oil their application in controlled delivery metronidazole probiotics. were prepared by mixing span‐40 organogels with aqueous polysaccharide sol. microstructure was characterized fluorescent microscope. then for mechanical using texture analysis. flow behavior gels studied rheometer. micrographs suggested uniform distribution continuous phase. viscoelastic nature a shear...
Abstract The present work deals with preparation of the olive oil (OO) based organogels using sorbitan monostearate (SMS) and monopalmitate (SMP) as organogelators for controlled drug delivery applications. Metronidazole (MZ) was used model drug. Gels were prepared by solubilizing in OO at 60°C under stirring. As solution cooled down, gelator molecules precipitate an isotropic phase having networked structures, which immobilized OO. Formation 3D structure confirmed light, contrast, scanning...
Abstract In this study, we dealt with the development of lecithin‐based organogels using sunflower oil as apolar phase. Metronidazole (MZ) was used a model drug. The were characterized by microscopy (light and phase contrast), Fourier transform infrared spectroscopy, X‐ray diffraction, differential scanning calorimetry, rheology, alternating‐current impedance, hemocompatibility, antimicrobial analysis, in vitro drug release. Microscopic analysis revealed presence spherical reverse micellar...
Polyoxyethylene sorbitan monooleate (Tween-80)/sorbitan (Span-80)-based organogels were prepared by a fluid-filled structure mechanism varying the composition of organogels. The microstructures studied light microscopy. subjected to accelerated stability test and time-dependent test. stable characterized X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) simultaneous differential thermal analysis (DTA)-thermal gravimetric (TGA), pH DC impedance measuring devices....
Abstract The current study describes the preparation and characterization of thermoreversible span‐60 sunflower oil (SO)‐based organogels as a matrix for drug delivery. Effect gelator concentration on properties was studied by physical property evaluation, stability, light microscopy, FTIR spectroscopy, XRD, thermal analysis, pH, hemocompatibility studies. release kinetics antimicrobial efficacy salicylic acid loaded were studied. rate gelation gels found to be quicker in with higher...
Abstract The present study deals with the modulation of sunflower oil (SO) and sorbitan monopalmitate (SM) organogels using water. gels were prepared by heating either SO–SM mixture or SO–SM–water at 60°C subsequently cooling to room temperature. characterized microscopy (light electron), Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), differential thermal analysis, rheometry, pH, dc impedance, hemocompatibility, antimicrobial studies. without water (G) found be pale...
The current study deals with the characterization of sunflower oil- and protein-based bigels for drug delivery applications. Span-40 was used as an organogelator preparation bigels. were characterized by microscopy, XRD, thermal, texture studies impedance spectroscopy. microscopic revealed that droplets apolar in nature (organogels), while continuum phase polar (protein hydrogel matrix). Incorporation proteins improved stability release drugs followed diffusion kinetics. showed good...
In recent years, chitosan, a biocompatible natural polymer, having cellulosic backbone has gained importance in various biomedical applications like wound healing, tissue engineering, surface modifications of implantable devices, and drug delivery. This may be attributed to the versatile chemistry polymer. Various chitosan-mediated delivery systems have been developed improve bioavailability drug(s) categorized either as nanoparticulate, microparticulate, or macro systems. All these their...
Abstract The current study deals with the development of lanolin‐based emulsion gels by hot emulsification method. Bright‐field, phase contrast, and fluorescent micrographs have shown uniform distribution circular water droplets in formulations. Coalescence was observed containing higher proportion water. Fourier transform infrared spectrophotometric studies indicated absence Ln‐drug chemical interactions. X‐ray diffraction suggested an increase amorphousness incorporation into gel...
ABSTRACT In this paper, the mechanical properties of sunflower oil‐span 40‐natural gum bigels were evaluated. The prepared by mixing oleogels 40 and hydrogels natural gums. types molecular interactions occurring studied FTIR spectroscopy. Rheological textural behavior was determined dynamic rheological studies a static tester. Peleg Normand equation used to determine viscoelastic bigels. efficiency these food‐grade as carriers for delivery metronidazole (model drug) studied. vitro drug...
Abstract The study describes the development of gelatin based emulsion hydrogels with different proportions sunflower oil. During preparation hydrogels, microstructures emulsions were studied under light microscope. characterized by microscopy, swelling property, mucoadhesivity, pH, dc impedance measurements, and hemocompatibility studies. Salicylic acid was incorporated within oil phase, its release behavior studied. microscopy indicated that droplet size distribution becomes monodispersed...
Abstract Background Plasmodium vivax remains a major challenge for malaria control and elimination due to its ability cause relapsing illness. To prevent relapses the Indian National Center Vector Borne Diseases Control (NCVBDC) recommends treatment with primaquine at dose of 0.25 mg/kg/day provided over 14 days. Shorter courses may improve adherence effectiveness. Methods This is hospital-based, randomised, controlled, open-label trial in two centres India. Patients above age 16 years,...
ABSTRACT. Surveillance for genetic markers of resistance can provide valuable information on the likely efficacy antimalarials but needs to be targeted ensure optimal use resources. We conducted a systematic search and review publications in seven databases compile marker data from studies India. The sample collection identified this was between 1994 2020, these were published 2022. In all, Plasmodium falciparum Kelch13 (PfK13), P. dihydropteroate synthase, dihydrofolate reductase (PfDHPS)...
An open-label, randomized, multi-center trial was conducted to compare the immunogenicity and safety of an indigenously developed tetravalent DTwP-Hib vaccine, Easyfour®-TT with a commercially available Quadrovax®. A total 244 infants in good health, aged 6–10 weeks, were randomized 1:1 allocation receive three doses test or comparator vaccine. Immunogenicity vaccines determined by measuring baseline post-vaccination antibody response against vaccine antigens; evaluated terms local systemic...