A5050802580- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Bacterial Infections and Vaccines
- Genomics and Phylogenetic Studies
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Microbial Natural Products and Biosynthesis
- bioluminescence and chemiluminescence research
- Marine and coastal plant biology
- Food composition and properties
- Microbial Community Ecology and Physiology
- Antibiotic Resistance in Bacteria
- Aquaculture disease management and microbiota
- SARS-CoV-2 and COVID-19 Research
- Cellular transport and secretion
- COVID-19 Clinical Research Studies
- Photoreceptor and optogenetics research
- Vibrio bacteria research studies
- Fungal and yeast genetics research
- Marine Invertebrate Physiology and Ecology
- Advanced Chemical Sensor Technologies
- Microbial Metabolic Engineering and Bioproduction
- Protist diversity and phylogeny
- Bioenergy crop production and management
- RNA modifications and cancer
University of Salento
2016-2025
Interface (United Kingdom)
2019
John Wiley & Sons (United States)
2019
CoNISMa
2016
Istituto Nazionale di Fisica Nucleare, Sezione di Lecce
1999-2013
In-Q-Tel
2008-2011
Food Research Institute
2008
University of Naples Federico II
1990-2001
Institute for Experimental Endocrinology and Oncology
1988-1999
Texas Medical Center
1992
Charcot-Marie-Tooth (CMT) type 2 neuropathies are a group of autosomal-dominant axonal disorders genetically and clinically heterogeneous. In particular, CMT 2B (CMT2B) characterized by severe sensory loss, often complicated infections, arthropathy, amputations. Recently, four missense mutations in the small GTPase Rab7 associated with Charcot-Marie Tooth phenotype have been identified. These target highly conserved amino acid residues. However, nothing is known about whether how these...
While much data exist in the literature about how Neisseria meningitidis adheres to and invades human cells, its behavior inside host cell is largely unknown. One of essential meningococcal attributes for pathogenesis polysaccharide capsule, which has been shown be important bacterial survival extracellular fluids. To investigate role capsule intracellular survival, we used B1940, a serogroup B strain, isogenic derivatives, lack either or both lipooligosaccharide outer core, infect...
Wheat (Triticum spp. L.), rye (Secale cereal and barley (Hordeum vulgare L.) seeds contain peptides toxic to celiac patients. Maize (Zea mays rice (Oryza sativa are distant relatives of wheat as well sorghum (Sorghum bicolor (L.) Moench) known be safe for celiacs. Both immunochemical studies in vitro vivo challenge wheat-free food products support this conclusion, although molecular evidence is missing. The goal the present study was provide biochemical genetic that In silico analysis...
Grain sorghum (Sorghum bicolor) is a gluten-free cereal grown around the world and food staple in semi-arid subtropical regions. Sorghum diverse crop with range of pericarp colour including white, various shades red, black, all which show health-promoting properties as they are rich sources antioxidants such polyphenols, carotenoids, well micro- macro-nutrients. This work examined grain composition three varieties possessing colours (white, black) Mediterranean region. To determine...
Abstract Background Among the mechanisms of mitochondrial quality control (MQC), generation mitochondria-derived vesicles (MDVs) is a process to avoid complete failure mitochondria determining lysosomal degradation damaged proteins. In this context, RAB7, late endocytic small GTPase, controls delivery MDVs endosomes for subsequent degradation. We previously demonstrated that RAB7 has pivotal role in response cisplatin (CDDP) regulating resistance drug by extracellular vesicle (EVs)...
The polycistronic mRNA of the histidine operon is subject to a processing event that generates rather stable transcript encompassing five distal cistrons. molecular mechanisms by which such produced were investigated in Escherichia coli strains carrying mutations several genes for exo- and endonucleases. experimental approach made use S1 nuclease protection assays on vivo synthesized transcripts, site-directed mutagenesis construction chimeric plasmids, dissection reaction RNA mobility...
ABSTRACT Crenothrix polyspora Cohn 1870 and Clonothrix fusca Roze 1896 are two filamentous, sheathed microorganisms exhibiting complex morphological differentiation, whose phylogeny physiology have been obscure for a long time due to the inability cultivate them. Very recently, DNA sequencing data from uncultured C. -enriched material suggested that is methane-oxidizing γ-proteobacterium (39). In contrast, possible ecological function of , originally considered developmental stage unknown....
In this article, we report on the nucleotide sequences of rol genes Escherichia coli O75 and Salmonella typhimurium LT2. The gene in E. was previously shown to encode a 36-kDa protein that regulates size distribution O-antigen moiety lipopolysaccharide. S. consist 978 984 nucleotides, respectively. homology between these two found be 68.9%. Both are transcribed counter histidine operon code for deduced polypeptides 325 327 amino acids, identified unknown function share transcription...
The Italian Toscano cigar production includes a fermentation step that starts when dark fire-cured tobacco leaves are moistened and mixed with ca. 20% prefermented to form 500-kg bulk. dynamics of the process, lasting 18 days, has never been investigated in detail, limited information is available on microbiota involved. Here we show invariably associated following: (i) an increase temperature, pH, total microbial population; (ii) decrease reducing sugars, citric malic acids, nitrate...
Summary Vetiver is the only grass cultivated worldwide for root essential oil, which a mixture of sesquiterpene alcohols and hydrocarbons, used extensively in perfumery cosmetics. Light transmission electron microscopy demonstrated presence bacteria cortical parenchymatous oil‐producing cells lysigen lacunae close association with oil. This finding evidence that axenic produces vitro trace amounts oil strikingly different composition compared oils from vivo plants stimulated hypothesis an...
In bacterial genomes, there are two mechanisms to terminate the DNA transcription: "intrinsic" or Rho-independent termination and Rho-dependent termination. Intrinsic terminators characterized by a RNA hairpin followed run of 6-8 U residues relatively easy identify using one numerous available prediction programs. contrast, is mediated Rho protein factor that, firstly, binds ribosome-free mRNA in site C > G content then reaches polymerase induce its release. Conversely on intrinsic...
Tidally-influenced subterranean settings represent natural geomicrobiological laboratories, relatively unexplored, that facilitate the investigation of new biomineralization processes. The unusual water chemistry Zinzulùsa Cave and its oligotrophic aphotic conditions have allowed development a unique ecosystem in which complex bacterial activities induce rare A diversified microbial community develops on centimeter-thick crusts form submerged part cave. are formed Ca-phosphate minerals,...