A5055657547- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Microbial Natural Products and Biosynthesis
- COVID-19 Clinical Research Studies
- Genomics and Phylogenetic Studies
- Bacterial biofilms and quorum sensing
- Bacterial Infections and Vaccines
- Biochemical and Molecular Research
- RNA modifications and cancer
- Advanced Photocatalysis Techniques
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Insect Pest Control Strategies
- ATP Synthase and ATPases Research
- Gut microbiota and health
- Phytochemicals and Antioxidant Activities
- Bacteriophages and microbial interactions
- Geochemistry and Elemental Analysis
- Aquaculture disease management and microbiota
- Helicobacter pylori-related gastroenterology studies
- TiO2 Photocatalysis and Solar Cells
- Copper-based nanomaterials and applications
- Mitochondrial Function and Pathology
- Food composition and properties
- Force Microscopy Techniques and Applications
University of Salento
2018-2025
Interface (United Kingdom)
2019
John Wiley & Sons (United States)
2019
Grain sorghum (Sorghum bicolor) is a gluten-free cereal grown around the world and food staple in semi-arid subtropical regions. Sorghum diverse crop with range of pericarp colour including white, various shades red, black, all which show health-promoting properties as they are rich sources antioxidants such polyphenols, carotenoids, well micro- macro-nutrients. This work examined grain composition three varieties possessing colours (white, black) Mediterranean region. To determine...
Abstract The current SARS covid-19 epidemic spread appears to be influenced by ethnical, geographical and sex-related factors that may involve genetic susceptibility diseases. Similar SARS-CoV, SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor invade cells, notably type II alveolar epithelial cells. Importantly, ACE2 gene is highly polymorphic. Here we have used in silico tools analyze the possible impact of single-nucleotide polymorphisms (SNPs) on interaction with...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplasia, characterized by early metastasis, low diagnostic rates at stages, resistance to drugs, and poor prognosis. There an urgent need better characterize this disease in order identify efficient diagnostic/prognostic biomarkers. Since microRNAs (miRNAs) contribute oncogenesis metastasis formation PDAC, they are considered potential candidates for fulfilling task. In work, levels two miRNA subsets (involved...
Tidally-influenced subterranean settings represent natural geomicrobiological laboratories, relatively unexplored, that facilitate the investigation of new biomineralization processes. The unusual water chemistry Zinzulùsa Cave and its oligotrophic aphotic conditions have allowed development a unique ecosystem in which complex bacterial activities induce rare A diversified microbial community develops on centimeter-thick crusts form submerged part cave. are formed Ca-phosphate minerals,...
Biofilm formation in common public places and hospitals is of great concern. Active antimicrobial coatings can prevent the bacterial biofilms spreading primary secondary infections caused by contagious bacteria viruses. In present work, we report a simple spray coating process using copper oxide (CuO) nanoparticles (NPs) dispersed titanium dioxide (TiO
Sorghum (Sorghum bicolor L.) is a gluten-free cereal with many varieties containing greater amounts of bioactive compounds than other grains. In this work, the phenolic composition and antioxidant capacity were compared in three sorghum grown Mediterranean, consisting different pericarp colors: white, red, black. The qualitative quantitative profiles acidified aqueous methanol extracts whole grain flours elucidated through ultrahigh performance liquid chromatography (UHPLC) coupled to...
Spiramycin is a 16-membered macrolide antibiotic currently used in therapy to treat infections caused by Gram-positive bacteria responsible for respiratory tract infections, and it also effective against some Gram-negative Toxoplasma spp. In contrast, Pseudomonas aeruginosa, which one of the pathogens most concern globally, intrinsically resistant spiramycin. this study we show that spiramycin inhibits expression virulence determinants P. aeruginosa absence any significant effect on...
Abstract Maculinea (= Phengaris ) are endangered butterflies that characterized by a very complex biological cycle. larvae behave as obligate parasites whose survival is strictly dependent on both particular food plants and species-specific Myrmica ants. In this interaction, caterpillars induce workers to retrieve rear them in the nest chemical acoustic deception. Social insect symbiotic microorganisms play key role intraspecific interspecific communication; therefore, it possible...
RAB7A is a small GTPase that controls the late endocytic pathway but also cell migration through RAC1 (Ras-related C3 botulinum toxin substrate 1) and vimentin. In fact, regulates vimentin phosphorylation at different sites assembly, and, in this study, we identified domains interacting with RAB7A. As several kinases could be responsible for phosphorylation, investigated whether modulation of expression affects activity these kinases. We discovered AKT PAK1, demonstrated increased Ser38...
Due to the increased resistance all available antibiotics and lack of vaccines, Neisseria gonorrhoeae (the gonococcus) poses an urgent threat. Although mechanisms virulence antibiotic have been largely investigated in this bacterium, very few studies addressed stringent response (SR) that pathogenic bacteria controls expression genes involved host-pathogen interaction tolerance persistence toward antibiotics. In study, results transcriptome analysis a clinical isolate N. gonorrhoeae, after...
In Neisseria meningitidis the HrpA/HrpB two-partner secretion system (TPS) was implicated in diverse functions including meningococcal competition, biofilm formation, adherence to epithelial cells, intracellular survival and vacuolar escape. These could be attributed distinct domains of secreted HrpA.A yeast two-hybrid screening, vitro pull-down assay immunofluorescence microscopy experiments were used investigate interaction between HrpA dynein light-chain, Tctex-type 1 (DYNLT1). silico...
The underwater environment of Grotta Giusti (Monsummano Terme, Italy) is a suggestive setting with different types speleothems including "leafy" and "cauliflower" concretions along the walls roof, conical pseudo-stalagmites on floor. Very high calcium dissolved CO2 levels, massive carbonate precipitation characterize this cave environment. Yet, life thrives leafy concretion surfaces loads cultivable heterotrophic microorganisms around 105 colony-forming units per cm2. Bacillus licheniformis...
Spiramycin is a macrolide antibiotic and antiparasitic that used to treat toxoplasmosis various other infections of soft tissues. In the current study, we evaluated effects α-cyclodextrin, β-cyclodextrin, or methyl-β-cyclodextrin supplementation synthetic culture medium on biomass spiramycin production by Streptomyces ambofaciens ATCC 23877. We found high stimulatory effect when was supplemented with 0.5% (w/v) methyl-β-cyclodextrin, whereas α-cyclodextrin β-cyclodextrin weakly enhanced...
Reactive intermediate deaminase (Rid) proteins are enzymes conserved in all domains of life. UK114, a mammalian member RidA subfamily, has been firstly identified as component liver perchloric acid-soluble (L-PSP). Although still poorly defined, several functions have attributed to the protein UK114/RIDA, including reactive deamination activity. The expression UK114/RIDA observed some tumors, arousing interest this an evaluable tumor marker. However, other studies reported negative...