A5022530899- CAR-T cell therapy research
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
Universitätsklinikum Würzburg
2022-2023
In the past years, several studies investigated how distinct immune cell subsets affects post-myocardial infarction repair. However, whether and tissue environment controls these local responses has remained poorly understood. We sought to investigate antigen-specific T-helper cells differentiate under myocardial milieu's influence.
Abstract Background Myocardial infarction (MI) is a sterile inflammatory condition associated with tissue injury that results in the activation of T helper cell targeting cardiac antigens. However, differentiation trajectories and situ activity heart-specific CD4 + cells activated MI context remain poorly understood. Methods Herein, we combined T-cell receptor transgenic models myocardial protein, single-cell transcriptomics, functional phenotyping to elucidate how myosin-specific (TCR-M)...