A5033329636- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Family and Disability Support Research
- Anesthesia and Pain Management
- Pancreatic function and diabetes
- Genetic Mapping and Diversity in Plants and Animals
- Multiple Myeloma Research and Treatments
- Corneal Surgery and Treatments
- HIV Research and Treatment
- Adipose Tissue and Metabolism
- Traumatic Brain Injury Research
- Innovations in Medical Education
- Ophthalmology and Eye Disorders
- Assistive Technology in Communication and Mobility
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Function and Risk Factors
- Ergonomics and Musculoskeletal Disorders
- Vestibular and auditory disorders
- Reproductive tract infections research
- Intraocular Surgery and Lenses
University of Wisconsin–Madison
2016-2025
Johnson & Johnson (United States)
2024
UW Health University Hospital
2019-2024
Berman Center for Outcomes and Clinical Research
2021
Google (United States)
2019
University of Wisconsin Carbone Cancer Center
2019
Sanford Burnham Prebys Medical Discovery Institute
2014
Duke University
2014
National Eye Institute
2005-2011
Dana (United States)
2004-2011
<h3>Objective</h3> To estimate the prevalence of refractive errors in persons 40 yearsand older. <h3>Methods</h3> Counts with phakic eyes and without spherical equivalentrefractive error worse eye +3 diopters (D) or greater, −1D less, −5 D less were obtained from population-based eyesurveys strata gender, race/ethnicity, 5-year age intervals. Pooledage-, gender-, race/ethnicity–specific rates for each refractiveerror applied to corresponding stratum-specific US, Western European,and...
<h3>Objective</h3> To determine the prevalence and causes of low vision in a large sampleof nursing home residents. <h3>Methods</h3> Twenty-eight homes on Eastern Shore Maryland Delawarewere enrolled clinical trial to assess impact restoration/rehabilitationon Visual acuity was measured using both recognitioncharts preferential looking techniques. An ophthalmologist examined allresidents with visual worse than 20/40 better-seeing eye anddetermined primary cause for decreased vision. Results...
To determine the association between performance on selected tasks of everyday life and impairment in visual acuity contrast sensitivity.Visual sensitivity were obtained a population-based sample 2520 older African American white subjects. Performance was assessed mobility, daily activities with strong component, visually intensive tasks. Disability defined as less than 1 SD below mean. Receiver operating characteristic curve analyses used to evaluate specificity thresholds loss for...
An unbiased systems approach was used to define energy metabolic events that occur during the pathological cardiac remodeling en route heart failure (HF).Combined myocardial transcriptomic and metabolomic profiling were conducted in a well-defined mouse model of HF allows comparative assessment compensated decompensated (HF) forms hypertrophy because pressure overload. The overload data sets also compared with transcriptome metabolome for an adaptive (physiological) form endurance exercise...
Highlights•Host genotype affects the abundance of taxa associated with metabolic disease•Gut microbiota susceptibility to diet-induced disease•The gut microbiome modulates insulin secretionSummaryGenetic variation drives phenotypic diversity and influences predisposition disease. Here, we characterize phenotypes eight genetically distinct inbred mouse strains in response a high-fat/high-sucrose diet. We found significant diabetes-related composition among different dietary challenge...
Purpose. To determine the association between visual field loss and orientation mobility (O&M) performance in a population-based sample of older adults to identify specific regions that are most strongly associated with O&M performance. Methods. A 1504 persons ages 72 92 was enrolled third round Salisbury Eye Evaluation. Monocular fields (60° radius) were tested 81-point, single intensity (24 dB) screening test strategy on Humphrey Field Analyzer. Binocular estimated from combination...
Purpose To estimate the relationships between ocular parameters and tonometrically measured intraocular pressure (IOP), to determine influence of on different instrument measurements IOP, evaluate association with a parameter called hysteresis. Methods Patients presenting at glaucoma clinic were recruited for this study. Subjects underwent IOP measurement Goldmann applanation tonometer (GAT), TonoPen, Reichert Ocular Response Analyzer (ORA), also central corneal thickness (CCT), axial...
OBJECTIVES The prevalence rate of diabetes is probably higher in Hispanics than Caucasians, although there controversy about differences the risk diabetic retinopathy. purpose study to determine rates and retinopathy a population-based aged ≥40 years. RESEARCH DESIGN AND METHODS—Proyecto VER random sample Hispanic populations years Arizona. A total 4,774 individuals (71.6% eligible sample) completed examinations. Diabetes was defined as self-report physician diagnosis or HbA1c value ≥7.0%....
purpose. To estimate the rate of visual field progression in open-angle glaucoma (OAG) subjects, by using data from population-based cross-sectional studies. methods. Subjects with OAG were identified nine surveys randomly sampled populations standard criteria for glaucomatous optic neuropathy. European, African, Chinese, and Hispanic ethnicity. The measure damage was mean deviation (MD) an automated test (Humphrey Field Analyzer; Carl Zeiss Meditec, Inc., Dublin, CA). all subjects' worse...
Significance The hallmark of remyelination in the CNS has been proposed to be presence thin myelin sheaths. This demonstrated multiple experimental models and sclerosis. It is only surrogate marker remyelination, therefore a crucial fingerprint repair. However, this challenged recently separate studies, which, by implication, degree or remyelinated axons underestimated. In article, we provide evidence from two different that sheaths short internodes persist almost indefinitely. Future...
The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the expression etiology diabetes, we sensitized genetically diverse mouse population Western diet high fat (45% kcal) and sucrose (34%) carried out genome-wide association mapping diabetes-related phenotypes. We quantified mRNA abundance islets identified 18,820 QTL. applied mediation analysis to identify candidate causal driver genes at affect numerous transcripts....
Abstract Natural variation in gene expression is pervasive within and between species, it likely explains a significant fraction of phenotypic individuals. Phenotypic acute systemic responses can also be leveraged to reveal physiological differences how individuals perceive respond environmental perturbations. We previously found extensive the transcriptomic response ethanol exposure two wild isolates common laboratory strain Saccharomyces cerevisiae. Many persisted across several modules...
Blastomyces is a dimorphic fungus that infects persons with or without underlying immunocompromise. To date, no study has compared the clinical features and outcomes of blastomycosis between immunocompromised immunocompetent persons.A retrospective adult patients proven from 2004-2016 was conducted at University Wisconsin. Epidemiology, features, were analyzed among solid-organ transplantation (SOT) recipients, non-SOT immunocompromise (non-SOT IC), (NIC).A total 106 cases met inclusion...
Fc-mediated antibody effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can contribute to the containment HIV-1 replication but whether activities are sufficient for protection is unclear. We previously identified an variable 2 (V2) apex of Env trimer (PGT145) that potently directs lysis SIV-infected cells by NK poorly neutralizes SIV infectivity. To determine if ADCC protection, separate groups six rhesus macaques were treated with PGT145 or a control (DEN3)...