A5012997583- Neurological disorders and treatments
- Epilepsy research and treatment
- Multiple Sclerosis Research Studies
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Vagus Nerve Stimulation Research
- Genetic Neurodegenerative Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroscience and Neuropharmacology Research
- Vascular Malformations Diagnosis and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Hereditary Neurological Disorders
- Prion Diseases and Protein Misfolding
- RNA and protein synthesis mechanisms
- Dermatological and Skeletal Disorders
- Pharmacological Effects and Toxicity Studies
- Venous Thromboembolism Diagnosis and Management
- Fetal and Pediatric Neurological Disorders
- Electroconvulsive Therapy Studies
- Stroke Rehabilitation and Recovery
- Neurofibromatosis and Schwannoma Cases
Pitié-Salpêtrière Hospital
2015-2023
Sorbonne Université
2014-2023
Inserm
2014-2023
Hôpital Charles-Foix
2023
Assistance Publique – Hôpitaux de Paris
2019
Institut Mondor de Recherche Biomédicale
2019
Institut du Cerveau
2015
Hôpitaux Universitaires Henri-Mondor
2015
University of Geneva
2014
Université Paris Cité
2007-2008
The DEPDC5 (DEP domain-containing protein 5) gene, encoding a repressor of the mTORC1 signaling pathway, has recently emerged as major gene mutated in familial focal epilepsies. We aimed to further extend role cortical dysplasias (FCDs).Seven patients from 4 families with mutations and epilepsy associated FCD were recruited investigated at clinical, neuroimaging, histopathological levels. was sequenced genomic blood brain DNA.All had drug-resistant epilepsy, 5 them underwent surgery, 1...
Patients undergoing surgical resection of medial frontal lesions may present a transient postoperative deficit that remains largely unpredictable. The authors studied the role supplementary motor area (SMA) in occurrence this using fMRI.Twenty-three patients underwent preoperative fMRI before lesions. Tasks included self-paced flexion/extension left and right hand, successively. Preoperative data were compared with MRI neurologic outcome.Following surgery, 11 had from which all recovered...
To study the prevalence of DEPDC5 mutations in a series 30 small European families with phenotype compatible autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).Thirty unrelated referred ADNFLE were recruited France, Italy, Germany, Belgium, and Norway. Whole-exome sequencing was performed 10 probands direct coding sequence 20 probands. Testing for nonsense-mediated messenger RNA decay (NMD) lymphoblastic cells.Exome revealed splice acceptor mutation (c.2355-2A>G) proband German...
Bradykinin-mediated angioedema (AE) is a complication associated with thrombolysis for acute ischemic stroke. Risk factors are unknown and management discussed.To clarify risk bradykinin-mediated AE after stroke.In case-control study conducted at French reference centre bradykinin angiœdema, patients stroke diagnosis of were compared to controls treated treatment without angiœdema.Fifty-three thrombolysis-related matched 106 control subjects. The sites attacks following mainly included...
Abstract Aims . To evaluate the safety and effectiveness of lacosamide in a real‐life setting with use flexible dose titration schedule individualised maintenance doses up to maximum approved 400 mg/day. Methods Adults diagnosis focal seizures, or without secondary generalization, were enrolled this open‐label Phase IV trial (NCT01235403). Lacosamide was initiated at 100 mg/day (50 mg bid) uptitrated over 12‐week period 200, 300 mg/day, based on seizure control. Although increases be...
AbstractObjective: To evaluate the effectiveness and safety of enfuvirtide–based therapy in treatment–experienced patients a clinical setting. Method: Retrospective study receiving enfuvirtide-based for minimum 2 months. Endpoints included virologic suppression, rebound, immunologic response, adverse events. Results: Sixty-four were eligible inclusion analysis. Median baseline viral load CD4+ count 4.7 log10 copies/mL (interquartile range [IQR], 4.0–5.2) 150 cells/mm3 (IQR, 60–250),...
OBJECTIVE: To clarify the MRI protocol required for exploration of cortical malformations.Cortical malformations are recognized as a frequent cause drug-resistant epilepsy. BACKGROUND: Mr D, 50 years old man, has severe epilepsy since he was 18 old. found malformation complex involving complete agenesis corpus callosum, cleft left parietal schizencephalic, whose walls lined by looking pachyric cortex malformation. DESIGN/METHODS: Our patient had neurological examination, EEG and...