A5026656918- Neurobiology of Language and Bilingualism
- Stroke Rehabilitation and Recovery
- EEG and Brain-Computer Interfaces
- Reading and Literacy Development
- Developmental and Educational Neuropsychology
- Language Development and Disorders
- Advanced Neuroimaging Techniques and Applications
- Obsessive-Compulsive Spectrum Disorders
- Text Readability and Simplification
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological Disorders and Treatments
- Voice and Speech Disorders
- Multisensory perception and integration
- Stuttering Research and Treatment
- Aging, Health, and Disability
- Agriculture and Rural Development Research
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Neonatal and fetal brain pathology
- Interpreting and Communication in Healthcare
- Educational and Psychological Assessments
- Spatial Neglect and Hemispheric Dysfunction
Universidad de Málaga
2015-2025
Instituto de Investigación Biomédica de Málaga
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2022
Global Brain Health Institute
2022
Universidad de Santiago de Chile
2022
University of San Andrés
2022
Motor speech function, including timing, is a key domain for diagnosing nonfluent/agrammatic variant primary progressive aphasia (nfvPPA). Yet, standard assessments use subjective, specialist-dependent evaluations, undermining reliability and scalability. Moreover, few studies have examined relevant anatomo-clinical alterations in patients with pathologically confirmed diagnoses. This study overcomes such caveats using automated timing analyses unique cohort of autopsy-proven cases.In...
Neuropsychiatric symptoms (NPS) have been insufficiently examined in persons with aphasia (PWA) because most previous studies exclude participants language and communication disorders.To report a two-part study consisting of literature review an observational on NPS post-stroke aphasia.Study 1 reviewed articles obtained from PubMed, PsycINFO, Google Scholar Cochrane databases after cross-referencing key words to disorders. Study 2 deficits activities daily living 20 PWA (median age: 58,...
This study explored the feasibility and effectiveness of a short-term (10-week) intervention trial using Donepezil administered alone combined with intensive language action therapy (ILAT) for treatment apathy depression in ten people chronic post-stroke aphasia. Outcome measures were Western Aphasia Battery Stroke Depression Questionnaire-21. Structural magnetic resonance imaging 18fluorodeoxyglucose positron emission tomography acquired at baseline after two endpoints (Donepezil...
OPINION article Front. Hum. Neurosci., 03 April 2017Sec. Cognitive Neuroscience Volume 11 - 2017 | https://doi.org/10.3389/fnhum.2017.00164
Donepezil (DP), a cognitive-enhancing drug targeting the cholinergic system, combined with massed sentence repetition training augmented and speeded up recovery of speech production deficits in patients chronic conduction aphasia extensive left hemisphere infarctions (Berthier et al., 2014). Nevertheless, still unsettled question is whether such improvements correlate restorative structural changes gray matter white pathways mediating production. In present study, we used pharmacological...
Lesion-symptom mapping studies reveal that selective damage to one or more components of the speech production network can be associated with foreign accent syndrome, changes in regional (e.g., from Parisian Alsatian accent), stronger accent, re-emergence a previously learned and dormant accent. Here, we report loss after rapidly regressive Broca's aphasia three Argentinean patients who had suffered unilateral bilateral focal lesions network. All were monolingual speakers different native...
Foreign accent syndrome (FAS) is a speech disorder that defined by the emergence of peculiar manner articulation and intonation which perceived as foreign. In most cases acquired FAS (AFAS) new secondary to small focal lesions involving components bilaterally distributed neural network for production. past few years has also been described in different psychiatric conditions (conversion disorder, bipolar schizophrenia) well developmental disorders (specific language impairment, apraxia...
Background: Mitigated echolalia (ME) is a symptom of aphasia which refers to seemingly deliberate repetition just-heard words and phrase fragments. ME has historically been viewed as compensatory strategy aimed strengthen auditory comprehension. Nevertheless, this hypothesis other possible functional deficits underlying have not evaluated so far.Aims: This study (a) reappraise in the frame modern neuroscience; (b) report effects Constraint-Induced Aphasia Therapy (CIAT) cognition-enhancing...
Linguistic anxiety (LA) is an abnormal stress response induced by situations that require the use of verbal behaviour, and it accentuated during language testing in persons with aphasia (PWA). The presence LA PWA may jeopardize interpretation cognitive evaluations, leading to biased conclusions about severity alteration effectiveness treatments. In present study, we report case a woman (Mrs. A) severe chronic mixed transcortical due left frontal parietal haemorrhages partially spared...
Abstract Despite its prolific growth, neurolinguistic research on phonemic sequencing has largely neglected the study of individuals with highly developed skills in this domain. To bridge gap, we report multidimensional signatures two experts backward speech, that is, capacity to produce utterances by reversing order phonemes while retaining their identity. Our approach included behavioral assessments and forward speech alongside neuroimaging measures voxel-based morphometry, diffusion...
At present, language therapy is the only available treatment for childhood aphasia (CA). Studying new interventions to augment and hasten benefits provided by in children strongly needed. CA frequently emerges as a consequence of traumatic brain injury and, case adults, it may be associated with dysfunctional activity neurotransmitter systems. The use cognitive-enhancing drugs, alone or combined therapy, promotes improvement deficits aphasic adults. In this study we report 9-year-old...
Mixed transcortical aphasia (MTCA) is characterized by non-fluent speech and comprehension deficits coexisting with preserved repetition. MTCA may evolve to less severe variants of aphasias or even full language recovery. Mechanistically, MCTA has traditionally been attributed a disconnection between the spared left perisylvian network (PSLN) responsible for verbal repetition, damaged extrasylvian networks, which are production impairments. However, despite significant advances in vivo...
Background Perseverations in speech production tasks represent a pervasive symptom of chronic aphasia. Semantic perseverations (SPs) are defined as repetitive and unconscious specific linguistic forms previously produced, heard, or seen which share semantic relatedness with the target word. Neurochemically, SPs have been attributed to weakened activation word due depletion neurotransmitter systems (acetylcholine dopamine) occurring context competitors.Aims The present pilot study seeks...
The acquisition and evolution of speech production, discourse communication can be negatively impacted by brain malformations. We describe, for the first time, a case developmental dynamic dysphasia (DDD) in right-handed adolescent boy (subject D) with cortical malformations involving language-eloquent regions (inferior frontal gyrus) both left right hemispheres. Language evaluation revealed markedly reduced verbal output affecting phonemic semantic fluency, phrase sentence generation...
Abstract Background and Objectives Motor speech function, including timing, is a key domain for diagnosing non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). Yet, standard assessments employ subjective, specialist-dependent evaluations, undermining reliability scalability. Moreover, few studies have examined relevant anatomo-clinical alterations in patients with pathologically-confirmed diagnoses. This study overcomes such caveats via automated timing analyses unique cohort...