A5107024052- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Biochemical Acid Research Studies
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Biotin and Related Studies
- Alcoholism and Thiamine Deficiency
- Ubiquitin and proteasome pathways
Centre National de la Recherche Scientifique
2013-2015
Inserm
2014-2015
Institut de Recherche en Cancérologie de Montpellier
2014-2015
Université de Montpellier
2015
Institut Regional du Cancer de Montpellier
2015
Institut de Génétique Moléculaire de Montpellier
2013
Synthesis and apoenzyme attachment of lipoic acid have emerged as a new complex metabolic pathway. Mutations in several genes involved the de novo pathway recently been described (i.e., LIAS, NFU1, BOLA3, IBA57), but no mutation was found so far specific process to apoenzymes pyruvate dehydrogenase (PDHc), α-ketoglutarate (α-KGDHc) branched chain α-keto (BCKDHc) complexes.Exome capture performed boy who developed Leigh disease following gastroenteritis had combined PDH α-KGDH deficiency with...
Highlights•Transcriptional target genes of E4F1 encode mitochondrial and checkpoint proteins•E4F1 controls the basal expression Chek1 gene•E4F1 transcriptional program impacts metabolism stress response•E4F1 is essential for cancer cell survival could be a therapiesSummaryRecent data support notion that group key regulators involved in tumorigenesis, including MYC, p53, E2F1, BMI1, share an intriguing capacity to simultaneously regulate cycle. Here, we show another factor, multifunctional...