A5006547806- Particle Accelerators and Free-Electron Lasers
- Advanced X-ray Imaging Techniques
- Gyrotron and Vacuum Electronics Research
- Particle accelerators and beam dynamics
- Advanced Electron Microscopy Techniques and Applications
- Advancements in Photolithography Techniques
- Advanced Optical Sensing Technologies
- Image Enhancement Techniques
- Laser-Plasma Interactions and Diagnostics
- Lymphoma Diagnosis and Treatment
- Ocular and Laser Science Research
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Image Fusion Techniques
- Spectroscopy and Laser Applications
- Photocathodes and Microchannel Plates
- Optical Systems and Laser Technology
- Semiconductor Quantum Structures and Devices
- Photonic and Optical Devices
- Data Visualization and Analytics
- Semiconductor Lasers and Optical Devices
- Chronic Lymphocytic Leukemia Research
- Advanced Image Processing Techniques
- Proteoglycans and glycosaminoglycans research
- Cell Image Analysis Techniques
- Advanced Vision and Imaging
Institute of Software
2024-2025
Chinese Academy of Sciences
2021-2025
Shanghai Advanced Research Institute
2025
Shanghai Institute of Applied Physics
2021-2024
University of Chinese Academy of Sciences
2021-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2022
Zhejiang Cancer Hospital
2022
The Shanghai High repetition rate XFEL and Extreme light facility (SHINE) is under construction aims at generating X-rays between 0.4 25 keV with three FEL beamlines rates of up to 1 MHz. soft X-ray beamline, FEL-II, will be ready for commissioning in 2025. It designed cover the photon energy from 3 keV, which baselines operation modes are self-amplified spontaneous emission (SASE), self-seeding, echo-enabled harmonic generation (EEHG), polarization control. Therefore, a high repetition-rate...
A critical technology for high-volume manufacturing of nanoscale integrated circuits is a high-power extreme ultraviolet (EUV) light source. Over the past decades, laser-produced plasma (LPP) sources have been actively utilized in this field. However, current LPP may provide insufficient average power to enable future at 3 nm node and below. In context,accelerator-based are being considered as promising tools EUV lithography. This paper proposes regenerative amplifier free-electron laser...
A critical technology for high-volume manufacturing of nanoscale integrated circuits is a high-power extreme ultraviolet (EUV) light source. Over the past decades, laser-produced plasma (LPP) sources have been actively utilized in this field. However, current LPP may provide insufficient average power to enable future at 3 nm node and below. In context, accelerator-based are considered be promising tools EUV lithography. This paper proposes regenerative amplifier free-electron laser source...
The spectroscopic methods for the ultrafast electronic and structural dynamics of materials require fully coherent extreme ultraviolet soft X-ray radiation with high-average brightness. Seeded free-electron lasers (FELs) are ideal sources delivering pulses. However, due to state-of-the-art laser system limitations, it is challenging meet seed laser's requirements sufficient energy modulation high repetition rates simultaneously. self-modulation scheme has been proposed recently demonstrated...
High-intensity, ultrashort, fully coherent X-ray pulses hold great potential for advancing spectroscopic techniques to unprecedented levels. Here, we propose a novel scheme generating high-brightness and femtosecond-scale soft radiation within seeded free-electron laser (FEL) operating at MHz repetition rates. This relies on the principles of self-modulation superradiance. A relatively weak energy modulation pre-bunched electron beam is significantly amplified by emitted in self-modulator....
The X-ray free-electron lasers (XFELs) are cutting-edge instruments pivotal in a broad range of fields, providing high-power pulses with durations spanning from femtoseconds to attoseconds. One the critical challenges XFEL facilities is simultaneous accommodation diverse requirements for operation modes and photon properties across different undulator lines. This paper proposes dipole-kicker combination bunch compressors vary electron length continuous-wave driven by superconducting linac....
Abstract Externally seeded free-electron lasers are promising for generating intense, stable, and fully coherent soft X-ray pulses. An earlier study demonstrates that high brightness radiation can be produced based on harmonic generation superradiant principles, termed high-brightness high-gain (HB-HGHG). However, the seed laser at ultraviolet region cannot induce sufficient energy modulation repetition rates due to state-of-the-art system limitations. A recently suggested self-modulation...
Abstract The X-ray free-electron laser (XFEL) is one of the most powerful tools in scientific frontiers due to its ultra-fast pulse duration and high peak brightness. non-invasive, energy spectrum monitoring XFEL pulses an emerging demand enhance operation. This work proposes a non-invasive photo-electron spectrometer equipped with four time-of-flight assemblies monitor high-repetition-rate XFEL. A comprehensive numerical model established for start-to-end simulations instrumentation,...
The formation of a double-horn current profile is challenging issue in the achievement electron bunch with high peak current, especially for high-repetition-rate X-ray free-electron lasers (XFELs) where more nonlinear and intricate beam dynamics propagation involved. Here, we propose to correct longitudinal phase space distortion photoinjector section dual-mode buncher. In combination evolutionary many-objective optimization, this method shown be effective manipulating at injector exit....
High-intensity, ultrashort, fully coherent X-ray pulses hold great potential for advancing spectroscopic techniques to unprecedented levels. Here, we propose a novel scheme generating high-brightness and femtosecond-scale soft radiation within seeded free-electron laser (FEL) operating at an MHz repetition rate. This relies on the principles of self-modulation superradiance. A relatively weak energy modulation pre-bunched electron beam is significantly amplified by emitted in self-modulator....
The wakefield is always an important issue in a free electron laser (FEL) facility. A longitudinal could lead to energy spread of bunch, and transverse deterioration quality bunch. As result, the performance FEL will be decreased under these impacts. Due discontinuous structures resistive wall chambers undulator section, ineluctable. Shanghai high-repetition-rate XFEL extreme light facility (SHINE) construction with three lines as planned. These have similar framework, thus we consider first...
Recently, the self-modulation scheme of a weakly pre-bunched electron beam has been proposed [Yan et al., Physical Review Letters 126, 084801 (2021)], which is great promise for high-repetition-rate seeded free-electron lasers (FELs), such as high-gain harmonic generation (HGHG). In this paper, systematically analyzed and optimized, further experiments in self-modulator resonant at second seed laser are conducted. The three-dimensional numerical simulations show that required intensity...
Background: Effective treatment choices for patients (pts) with relapsed/refractory (R/R) mature T- and NK-cell neoplasms after failure of standard therapies are limited. Tislelizumab (TIS), a humanized anti–PD-1 mAb, demonstrated outstanding efficacy favorable safety in pts R/R classical Hodgkin lymphoma or solid tumors. Aims: To evaluate the TIS neoplasms. Methods: This was global, multicenter, single-arm, open-label, phase 2 study (NCT03493451). Pts were enrolled into 3 cohorts stratified...