A5107973917- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- PARP inhibition in cancer therapy
- Gastric Cancer Management and Outcomes
- T-cell and Retrovirus Studies
- Digital Media and Philosophy
- Photodynamic Therapy Research Studies
- Cancer Risks and Factors
- Cancer Treatment and Pharmacology
- Neutropenia and Cancer Infections
- Cancer therapeutics and mechanisms
- Noise Effects and Management
- Fungal Plant Pathogen Control
- CNS Lymphoma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Cancer-related Molecular Pathways
- Health Promotion and Cardiovascular Prevention
- Plant Disease Resistance and Genetics
- CAR-T cell therapy research
- Climate Change and Health Impacts
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Chronic Myeloid Leukemia Treatments
West China Hospital of Sichuan University
2017-2023
Sichuan University
2017-2023
Xiamen University
2023
Lanzhou University
2018-2021
First Hospital of Lanzhou University
2018-2021
Northeast Agricultural University
2020
The Ohio State University
2012
3041 Background: Veliparib is a potent, oral inhibitor of PARP-1 and PARP-2. We previously reported phase I results veliparib cyclophosphamide (C). Evaluation C with doxorubicin (A) was conducted given activity anthracyclines in breast cancer treatment. Main objectives were to determine maximum tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetics (PK) AC PAR levels peripheral blood mononuclear cells (PBMCs). Methods: doses ranged from 50 150 mg every 12 h on days 1 - 4 fixed...
Introduction: Zanubrutinib is a selective and irreversible BTK inhibitor that has demonstrated potent inhibition of in prior studies, with minimal, off-target other kinases. We present updated safety efficacy results from phase 2 study zanubrutinib patients R/R MCL. Methods: In this single-arm, multicenter (ClinicalTrials.gov NCT03206970), oral (160 mg BID) was given to MCL until disease progression (PD) or unacceptable toxicity. Primary endpoint overall response rate (ORR) assessed by an...
2605 Background: Inhibition of poly (ADP-ribose) (PAR) polymerase (PARP) is expected to enhance the DNA-damaging effects chemotherapy. PARP has also been implicated in endothelial cell migration. A an orally available, potent inhibitor PARP-1 and PARP-2. C alkylator that on thrombospondin 1, cells T reg cells. Methods: Objectives were establish safety, tolerability, MTD combination with metronomic C; determine PK A; evaluate inhibition PBMCs tumor samples. Patients (pts) had histologically...
Objective: To investigate the efficacy and safety of pegaspargase, gemcitabine, oxaliplatin(P-Gemox) chemotherapy combined with radiotherapy in treatment newly diagnosed, stage IE to IIE Extranodal nasal type natural killer/T-cell lymphoma(ENKTL) patients.Method: P-Gemox was used analyze its clinical value factors affecting prognosis 43 diagnosed ENKTL patients. In addition, toxicity related assessed. Result: The complete remission rate 86.05% patients,the partial 6.98%, total effective...
Dandelion (Taraxacum mongolicum) is a perennial herb of the family Asteraceae, with high edible and medicinal value widely grown at medium low altitudes in China. In July 2019, purple spot dandelion was found field near Harbin City, Heilongjiang province, The disease incidence regionally reached 95% fields yield losses between 10 20%, seriously reducing economic food dandelion. Multiple, irregular brown spots were first observed on leaves this plant- that later developed into circular or...
Objective:The aim of this study is to comprehensively evaluate the values 18F-FDG PET/CT and PET in diagnosing extranodal nasal type natural killer/T cell lymphoma (ENKTL). Method:Studies about ENKTL diagnosed by until June 2018 were searched databases such as PubMed, Embase, Cochrane, Web Science, CNKI, CBM, VIP Wanfang. Two reviewers independently screened literature extracted data strictly according included excluded criterion, assessed bias risk 11 items using QUADAS-2 gulidline....
Objective: To evaluate the effect of daily average temperature on atteck allergic rhinitis (AR) by analyzing changes outpatient visits AR in Lanzhou. Methods: The meteorological and air pollution data Lanzhou City Departments Otorhinolaryngology head neck surgery First Hospital University, Second University Gansu Provincial People's from 2013 to 2017 were collected describe factors, pollutants AR. correlation among three factors was then analyzed Spearman rank analysis. Using distributed lag...
Background: The prognosis of patients with peripheral T-cell (PTCL) or lymphoblastic lymphoma (T-LBL) remains poor under current conditioning regimens before receiving autologous stem cell transplantation (ASCT). Methods: Patients PTCL T-LBL were enrolled to receiviing ASCT using the regimen chidamide, cladribine, gemcitabine and busulfan (ChiCGB). Positron emission tomography-computed tomography (PET/CT) was used evaluate response ASCT. Overall survival (OS) progression-free (PFS) employed...
With the development of globalization, culture convergence cities has become a common phenomenon, resulted in fading unique regional culture. How to utilize artworks convey local an important issue. This project explored connotations banyan tree, which symbolizes Minnan Southern China. The Kinect sensory device sensed number participants modulate visual representation tree's aerial roots, creating immersive interactive work that can establish connection between humans and tree. aims research...
4021 Background: Surgery alone has been proven inadequate to treat gastric carcinoma, which made combined therapy indispensable. This study is investigate potential role of perioperative chemotherapy and its long-term outcome. Methods: The objective safety efficacy FOLFOX7 regimen (oxaliplatin 130 mg/m2 iv 2 hr d1; lecovorin 400 5-fluorouracil 2,400 civ 46 hr, repeated every two weeks) as treatment for carcinoma. Eligible patients will be randomly assigned group A who receive 2-6 cycles...
3093 Background: Chemotherapies for cancer patients are often designed to inhibit growth or induce apoptosis in malignant cells. Several genotoxic agents have proved effective inducing significant DNA damage, such that is triggered the cell. Topotecan a chemical inhibitor of topisomerases. The inhibition topisomerases blocks ligation phosphate backbone and leads generation strand breaks. In this study we evaluated gamma-H2AX as marker drug efficacy, using antibodies recognize phosphorylated...
Introduction: Long-term survival of advanced-stage and relapsed extranodal NK/T cell lymphoma (ENKTL) is 33%–45%. Our previous study GLIDE (gemcitabine, L-asparaginase, ifosfamide, dexamethasone etoposide) chemotherapy reported complete response (CR) rate, 3-year overall (OS) these patients were 57.1% 56%, respectively. The role ASCT as consolidation in unclear. To address this issue, we analyzed the efficacy safety our treatment strategy, induction followed by ASCT, newly diagnosed stage IV...
Background: Double‐protein‐expression lymphomas (DEL) is a unique sub‐group of diffuse large B‐cell lymphoma (DLBCL) with co‐expression MYC and BCL‐2 on immunohistochemistry. Compared classic DLBCL, DEL has lower response to standard induction chemoimmunotherapy rituximab added cyclophosphamide, doxorubicin, vincristine, prednisone (R‐CHOP) poorer prognosis. Autologous stem cell transplant (ASCT) potentially curative treatment high‐risk relapsed/refractory lymphomas. However, the role ASCT...
Background: Effective treatment choices for patients (pts) with relapsed/refractory (R/R) mature T- and NK-cell neoplasms after failure of standard therapies are limited. Tislelizumab (TIS), a humanized anti–PD-1 mAb, demonstrated outstanding efficacy favorable safety in pts R/R classical Hodgkin lymphoma or solid tumors. Aims: To evaluate the TIS neoplasms. Methods: This was global, multicenter, single-arm, open-label, phase 2 study (NCT03493451). Pts were enrolled into 3 cohorts stratified...