Marina Derkho

ORCID: 0000-0003-3818-0556
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About
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Research Areas
  • Animal Nutrition and Health
  • Agriculture and Biological Studies
  • Human Health and Disease
  • Animal Nutrition and Physiology
  • Food Industry and Aquatic Biology
  • Effects of Environmental Stressors on Livestock
  • Meat and Animal Product Quality
  • Animal Virus Infections Studies
  • Reproductive Physiology in Livestock
  • Diverse Scientific Research Studies
  • Viral gastroenteritis research and epidemiology
  • Physical Education and Training Studies
  • Medicinal Plant Research
  • Biochemical effects in animals
  • Animal Diversity and Health Studies
  • Immune Response and Inflammation
  • Genetic and phenotypic traits in livestock
  • Animal health and immunology
  • Environmental Science and Water Management
  • Exercise and Physiological Responses
  • Advanced Scientific Research Methods
  • Rabbits: Nutrition, Reproduction, Health
  • vaccines and immunoinformatics approaches
  • Viral Infections and Vectors
  • Monoclonal and Polyclonal Antibodies Research

Ural State Agrarian University
2016-2025

Moscow State University of Technologies and Management named after K.G. Razumovskiy
2023

South Ural State University
2022

Tun Hussein Onn University of Malaysia
2021

University of Anbar
2021

Universidad Estatal de Bolívar
2021

GLA University
2021

Yanka Kupala State University of Grodno
2021

Iraqi University
2021

University of Mosul
2021

Context: The COVID-19 outbreak is caused by the transmission and infection of SARS-CoV-2 at end 2019. It has led many countries to implement lockdown policies prevent viral spreading. Problems arise in a patient because that leads systemic response immune system, specifically due cytokine storm. Moreover, antiviral drugs have not been found. Indonesia had variety traditional medicines, such as ‘jamu’. consists mixture natural ingredients Moringa oleifera Lam. Curcuma longa L. Aims: To...

10.56499/jppres21.1174_10.1.138 article EN cc-by-nc-nd Journal of Pharmacy & Pharmacognosy Research 2022-01-01

The aim of the study is analytical substantiation perspective trend – development specialized fermented foods. According to stable using a balanced diet for prevention and treatment gastrointestinal diseases (for which dairy products are enriched with probiotics), bioproduct has been developed, formulation includes cottage cheese, cream, starter cultures probiotic cultures, berry syrup, wheat bran. Cottage cheese prepared by fermentation mixture consisting buttermilk, bran biologically...

10.35940/ijrte.b3158.078219 article EN International Journal of Recent Technology and Engineering (IJRTE) 2019-07-30

The present research was carried out in an attempt to identify the problems associated with morphofunctional analysis of vertebrate animal’s leukocyte blood cells. For this samples four age groups chickens (Gallus gallus L.) were collected and as per recommendations International Council for Standardization Hematology identifying morpho-physiological characteristics leukocytes peripheral birds. Results current study based on sample early postnatal ontogenesis high-resolution color...

10.18006/2020.8(spl-2-aabas).s374.s380 article EN Journal of Experimental Biology and Agricultural Sciences 2020-12-15

Quercetin, a natural compound present in various fruits and vegetables, shows promise as potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM of Quercetin. The protein target Quercetin is identified analyzed using databases such NCBI, SEA, CTD, STRING. Protein-protein interaction (PPI) functional annotation are carried out based on obtained proteins. Molecular docking dynamics simulations employed AutoDock Vina WebGro tools analyze...

10.33640/2405-609x.3312 article EN cc-by-nc-nd Karbala International Journal of Modern Science 2023-08-06

High cattle productivity related with intensive metabolism and intake of all nutrients in a certain amount. The blood chemistry value cows taken biopreparation "Albit-Bio" was determined this study. Thus, there correlation between the protein composition cow's colostrum. In particular, first batch colostrum, dry matter content control experimental groups 32.59±1.87%, 38.09±0.93%, respectively. Similar differences were found other components which result intensity animals. A positive total...

10.1063/5.0000317 article EN AIP conference proceedings 2020-01-01

Physical and chemical changes caused by oxidative stress in the spermatozoa membrane can reduce function even lead to death. Cystamine (NH2-CH2-CH2-SH, β-mercaptoethylamine) is a natural substance that modulates endocrine metabolic status of animals. This has antioxidant anti-apoptotic effects inducing intracellular cysteine accumulation. used treat many diseases despite its side effects. Sheep semen sensitive stressful condition chilling storage, which restricts storage for artificial...

10.22092/ari.2021.355901.1735 article EN DOAJ (DOAJ: Directory of Open Access Journals) 2021-10-01

Relevance. Lysosomal cationic proteins (LCP) of granulocytic leukocytes: elastase, cathepsin G, proteinase-3, calgranulin, cathelicidins, defensins, lactoferrin, protegrins are active against viruses, bacteria, fungi, protozoa. The issues physiological regulatory, immune and pathological effects LCP their derivatives – neutrophil (heterophil) extracellular traps (NETs) on pathogens, healthy cellular tissue structures the body noted. Results. increment granulocytes is realized by: 1....

10.32634/0869-8155-2025-390-01-57-70 article EN Agrarian science 2025-01-28

The endophytic fungi that reside inside medicinal plants have the potential to produce various pharmaco-potential bioactive compounds. Graminicolous helminthosporium, Bipolaris australiensis and Cladosporium cladosporioides were isolated from different plants. GC-MS analysis of intra- extracellular products revealed presence metabolites, such as Anthracene, Brallobarbital, Benzo [h] quinolone, Ethylacridine, 2-Ethylacridine, Cyclotrisiloxane, 5 methyl 2 phenylindolizine,...

10.3390/antibiotics11111533 article EN cc-by Antibiotics 2022-11-02

Relevance. An overview is presented of the patterns appearance, physiological and clinical significance shadows cells, a comparative experimental cytomorphological analysis using example polychromatophilic erythroblasts ( PolyErythro ), erythroblast ShadErythro ) undifferentiated cells in peripheral blood smears chickens Gallus gallus L. Methods. The studied individuals were divided into four groups n = 40) depending on age Postembryonalis — P1, P7, P23, P42 : 1, 7, 23, 42 days postembryonic...

10.32634/0869-8155-2024-378-1-65-74 article EN Agrarian science 2024-01-19

Relevance . Immunometabolic status plays an important role in the formation of post-vaccination immunity against porcine circovirus type 2 sows. Methods The object study was sows that were vaccinated with “Ingelvac CircoFLEX” vaccine (Germany) on 21st day lactation after weaning their piglets (control group). In experimental group, vaccination combined administration “Transfer Factor” obtained from leukocytes hyperimmunized animals. effectiveness assessed by parameters immunometabolic and...

10.32634/0869-8155-2024-384-7-38-48 article EN Agrarian science 2024-07-23

Abstract This article presents relevance of distance learning technologies in the current stage public relations evolution owing to development level electronic devices for data transfer, processes economic integration, need “socialize” people with limited mobility, lifelong learning, and changing conditions interaction during 2020 th pandemic. Based on analysis legal as well organizational methodological documentation, available educational experience general higher education teachers our...

10.1088/1755-1315/699/1/012026 article EN IOP Conference Series Earth and Environmental Science 2021-03-01

The pathogenicity of PCV 2 in the body vaccinated piglets was studied based on results pathomorphological changes lungs and liver animals. work carried out commercial with vaccine Ingelvak CircoFLEX (Germany) against circovirus. used clinical, zootechnical, enzyme immunoassay research methods. It has been established that under conditions ongoing vaccination PCV2, 30.3% still do not have virus-neutralizing antibodies. main reason for culling animals are circovirus diseases respiratory...

10.21323/2414-438x-2023-8-1-4-11 article EN cc-by Theory and practice of meat processing 2023-04-02

Context: Mangosteen (Garcinia mangostana L.) is used in traditional medicine as an antibacterial, antioxidant, and anti-inflammatory. Aims: To determine the molecular mechanism potential of garciniaxanthone derivate compounds from G. SARS-CoV-2 antiviral prevent cytokine storm through silico approach. Methods: Ligand protein samples were obtained databases such PubChem Protein Databank, then drug-likeness analysis using Lipinski, Ghose, Veber, Egan, Muege rules on SwissADME server,...

10.56499/jppres23.1650_11.5.743 article EN cc-by-nc-nd Journal of Pharmacy & Pharmacognosy Research 2023-08-16

The results of a microscopic examination the internal organs virally aborted fetuses are presented in order to determine causes reproductive losses conditions subclinical circovirus infection sows. material study was tissues liver, placenta, umbilical cord, spleen and brain abortion sows whose pregnancy interrupted last trimester pregnancy. They had clinical signs diseases associated with PCV-2 infection. It has been established that virus ability penetrate feto-placental barrier from...

10.32634/0869-8155-2023-373-8-27-35 article EN Agrarian science 2023-08-25

Abstract The relevance of the problem under consideration is due to need use hardware cover a wide range in determination toxic elements (heavy metals) food. primary and important task ensure control quantitative content cadmium, introduction application fast reliable methods their research. analysis data obtained shows that all results on study milk for by stripping voltammetry atomic absorption spectrometry assessing precision operational error using method additions, are satisfactory....

10.1088/1755-1315/677/5/052051 article EN IOP Conference Series Earth and Environmental Science 2021-03-01

In numerous studies related to tumor prognosis, programmed death-ligand 1 (PD-L1) has been identified as a biomarker. This work aimed determine the prognostic importance of PD-L1 in breast cancer. We searched electronic databases such PubMed, Google scholar, home pages publishing groups, medical, clinical, and pharmaceutical sciences journals, well other relevant sources discover PD-1 expression cancer therapies also recurrence. The keywords used this search were autoimmunity, cell death, or...

10.3233/hab-220001 article EN Human Antibodies 2022-08-02

Relevance. Reproductive insufficiency of sows associated with circovirus infection is widespread in pig breeding enterprises. Therefore, an increase the effectiveness immunity formed animals during post-vaccination period crucial importance formation reproductive potential sows. Methods. The work was performed on sows, which at end suckling weaning piglets (on 21st day after delivery) were vaccinated against CVS-2 “Ingelvak Circoflex” vaccine (Germany). In experimental group, vaccination...

10.32634/0869-8155-2023-377-12-58-66 article EN Agrarian science 2023-12-20

Klebsiella pneumoniae is a gram-negative of bacteria that are known to cause variety nosocomial respiratory tract infections including pneumonia. K. also included in the ESKAPE group which has high resistance antibiotics. Therefore, alternative treatment for infection needed, one by developing vaccine. The aim this study was design vaccine against targeting outer membrane protein using immunoinformatics approaches. 1,708 then screened signalP, pred-TMBB2, and Blastp select proteins. selected...

10.52711/0974-360x.2024.00003 article EN Research Journal of Pharmacy and Technology 2024-01-19

Human immunodeficiency virus (HIV) is a genus of Lentivirus that triggers opportunistic diseases in the human body. HIV-1 has been major problem for world community long time and triggered pandemic. antiviral drugs with mechanism inhibiting specific proteins have found but some harmful side effects patients. Back to nature solutions can be used solve these problems. Natural ingredients as an alternative treatment infection allegedly more effective minimal effects. Antiviral candidate natural...

10.52711/0974-360x.2024.00282 article EN Research Journal of Pharmacy and Technology 2024-04-22
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