A5106524054- Paraoxonase enzyme and polymorphisms
- Single-cell and spatial transcriptomics
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- MicroRNA in disease regulation
- Hibiscus Plant Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Gene expression and cancer classification
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Cancer, Lipids, and Metabolism
- Biomedical Ethics and Regulation
- Hormonal Regulation and Hypertension
- Genetic Mapping and Diversity in Plants and Animals
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Autism Spectrum Disorder Research
- Neurogenetic and Muscular Disorders Research
- Adrenal Hormones and Disorders
- Gene Regulatory Network Analysis
- Apelin-related biomedical research
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Vector-Borne Animal Diseases
- Genomics and Chromatin Dynamics
University of Verona
1996-2025
ABSTRACT Previous studies in sports science suggested that regular exercise has a positive impact on human health. However, the effects of endurance and their underlying mechanisms are still not completely understood. One main debates regards modulation immune dynamics high‐intensity exercise. As part “Run 4 Science” project Verona, Italy, we conducted single‐cell RNA sequencing analysis half‐marathon amateur runners to investigate transcriptional peripheral blood mononuclear cells following...
The role of genetic and environmental factors, as well their interaction, in the natural history asthma, allergic rhinitis chronic obstructive pulmonary disease (COPD) is largely unknown. This mainly due to lack large-scale analytical epidemiological/genetic studies aimed at investigating these 3 respiratory conditions simultaneously. GEIRD project a collaborative initiative designed collect information on biomarkers inflammation oxidative stress, individual ecological exposures, diet,...
Low concentrations of plasma high-density lipoprotein (HDLs) are characteristic in metabolic syndrome (MS). The antioxidant ability HDLs is, at least part, attributable to pleiotropic serum paraoxonase (PON1). Different PON1 activities have been assessed 293 subjects with (n = 88) or without MS 205) and 195) 98) angiographically proven coronary artery disease (CAD). had low activities, a progressively decreasing trend by increasing the number abnormalities. activity versus 7-O-diethyl...
Gender disparity in melanoma is a complex issue where sex hormones could be engaged. Differences genetic variations are important understanding the mechanisms of melanoma. Post-transcriptional regulation prostaglandin-endoperoxide synthase (PTGS2) mRNA occurs through interplay specific trans-acting RNA-binding proteins and microRNAs. MiR-146a key player melanoma, modulating immune responses tumor microenvironment (TME). Polymorphisms PTGS2 gene rs20415G<C miR-146a rs2910164G>C have...
Variable number of tandem repeat (VNTR) DNA polymorphisms were studied in a random sample 100 Italians. The following systems used: YNH24/MspI, CMM101/Msp1, MLJ14/RsaI, EFD64.2/RsaI, EFD64.2/HinfI, JCZ3.1/HinfI and AW101/EcoRI. For each system, the allele size, frequency determined. alleles, for different VNTRs, varied from 21 to 44, heterozygosity 70 90%. All VNTRs showed modal distribution fragment size overrepresentation lower-molecular-weight fragments. them exhibited greater variability...
Background/Objectives: microRNAs (miRNAs) and circular RNA (circRNAs) show a close interconnection in the control of fundamental functions, such as cell proliferation tumor development. A full understanding this complex interconnected network is essential for better mechanisms underlying cancer progression. Hsa_circ_0079593 circRNA highly expressed melanoma associated with increased metastasis progression malignancy, whereas miR516b-5p microRNA whose expression lower several types, including...
Motivation and Objectives Many genetic variants mediate changes in gene expression. Some studies observed that variation of expression between alleles is common, this may contribute to human variability several traits (Lo et al, 2003, Main al.,2009). Next-generation sequencing (NGS) provides robust, comparable highly informative profiling data (Shendure al., 2008), rapidly replacing microarray methods gene-expression (GE) (Wold 2008, Wang 2009). In contrast microarrays, NGS based on counting...