Abstract We have successfully synthesized N‐substituted 7‐aminocoumarins by reacting 7‐hydroxycoumarins with amines using 5,6‐dichloro‐2,3‐dicyanopyrazine, a readily available multifunctional reagent. This reagent effectively brings both coupling partners into close proximity, facilitating dehydrative C─N reactions under mild, metal‐free conditions. Our approach demonstrates broad substrate scope and enables gram‐scale production.

Abstract Hypoxia is a condition caused by decrease in oxygen and often seen cases of cardiac ischemia, solid tumors, inflammation, other diseases. Tumor hypoxia can result cancer invasion, metastasis, decreased apoptosis, resistance to various therapies (chemotherapy, immunotherapy, radiotherapy), ultimately reducing overall survival rates. These effects underline the need monitor hypoxia‐associated specific markers for more effective therapeutic intervention. Nitroreductase (NTR) common...

We have performed K 2 S O 8 -glucose mediated oxidative coupling of alcohols with indoles in water for synthesis BIMs.

Abstract An efficient and regioselective trifluoromethylation method of indole at the C2 position with ecologically‐sound Langlois’ reagent (CF 3 SO 2 Na) under metal‐free conditions is described. K S O 8 in presence glucose room temperature has been utilized for generation CF radicals from Na. The desired product can be obtained good to excellent yields a wide scope substrate variability gram scalability.

A new type of fluorescent coumarin dye was synthesized using 7-azaspiroketals as the electron-donating auxochrome group. Such modifications resulted in high-quality fluorophores with improved solubility and brightness.

Abstract The majority of fluorescence imaging techniques make considerable use fluorescent dyes. Nevertheless, many structural modification currently in could not adjust the fluorophores′ properties (such as brightness, photostability, water solubility, and permeability). Herein, we report azaspiroketal‐based auxochrome on naphthalimide nitrobenzoxadiazole Their photophysical parameters revealed higher brightness solubility than their azetidine counterparts aqueous solution. Computational...

Herein, we demonstrate azacoumarins as potential fluorophores and their application in the synthesis of a “turn-on” fluorescent probe (PYCB) for detection H 2 O using carboxy benzyl boronic pinacol ester peroxide recognition unit.

Abstract A metal‐free formylation of imidazopyridines by direct decarboxylative cross‐coupling glyoxylic acid in presence K 2 S O 8 as oxidant under mild and neutral conditions is described. This reaction features a broad substrate scope, good functional group tolerance, generates products yields between 68–85 %. The translational capacity the from laboratory methodology to gram‐scale synthesis has also been ensured. involvement radical pathway demonstrated trapping experiments with...

A visible light-mediated, photocatalyst-free, persulfate-promoted approach has been explored for regioselective C-1 thiocyanation of imidazo[1,5- a ]pyridines.

Abstract Indole‐3‐carbinol is a natural compound present in cruciferous plants, which upon digestion, converts into 3,3′‐diindolylmethane (DIM) under acidic pH of the stomach. In recent years, various methods have been developed to improve synthesis DIM and its analogs because different pharmacological activities like anticancer, antimicrobial, anti‐inflammatory, etc. Among them, DIMs anticancer activity by modulation protein expression cell signaling pathways other factors has widely...

A highly inexpensive, and operationally simple seralite SRC-120 (strongly acidic cation exchange resin) catalyzed synthesis of 3,3′-bis(indolyl)methanes (BIMs) from indoles low/high boiling point carbonyl compounds under solvent-free condition is reported. Synthesis BIMs with low carbonyls at room temperature takes prolonged reaction time give yields high temperature. The reported method overcomes these limitations works remarkably well aldehydes/ketones in shorter times (5–10 min) microwave...

Abstract The Buchwald–Hartwig cross‐coupling reaction of 3‐bromo‐4‐indolylmaleimide with various anilines, aminopyridines and amides is described. A wide variety 3‐amino‐4‐indolylmaleimides 3‐amido‐4‐indolylmaleimides was prepared in good to excellent yields. We envisage that our protocol access 3‐(amino/amido)‐4‐indolylmaleimides will find use towards constituting new potentially biologically active compounds.

Abstract A transition metal‐free cascade synthesis of amides from alcohols was developed. Various reacted with N ‐hydroxyimides by tert ‐butyl nitrite to generate ‐hydroxyimide esters. The resulting active esters were subsequently amines in one pot. Further, we have illustrated the application developed protocol synthesizing anti‐Alzheimer compounds. detailed mechanistic exploration also carried out.

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Abstract A photoinduced approach for regioselective C-2 trifluoromethylation of indoles was achieved with CF3SO2Na under UV light irradiation (360–365 nm) at ambient conditions without any external photo activator. The key steps involve the in situ conversion reagent to CF3 • radical oxygen or air and irradiation. This proficient method has advantages mild reaction conditions, fair substrate tolerability, gram scalability.

An efficient copper iodide mediated synthesis of 3-cyanoimidazo[1,2-a]pyridines (4a-4m) from readily available methyl ketones, amino pyridines, and ethyl(ethoxymethylene)cyanoacetate is described. Copper(I)-catalyzed annulation between different aminopyridines various ketones resulted in formation imidazo[1,2-a]pyridines (IPs). The IPs undergo C3 cyanation by cyanide anion generated C(sp2)-CN bond cleavage ethyl(ethoxymethylene)cyanoacetate. Mechanistic studies indicate that the IP...