A5016395373- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Radiotherapy Techniques
- Tracheal and airway disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Pleural and Pulmonary Diseases
- Asthma and respiratory diseases
- Medical Imaging and Pathology Studies
- Antifungal resistance and susceptibility
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Respiratory viral infections research
- Head and Neck Cancer Studies
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Lymphoma Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Long-Term Effects of COVID-19
- Radiation Therapy and Dosimetry
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
University of Lausanne
2017-2025
Ospedale regionale di Lugano
2015-2025
Ente Ospedaliero Cantonale
2023-2025
Università della Svizzera italiana
2024-2025
University Hospital of Lausanne
2015-2023
Pulmonary Associates
2021
Hôpital Orthopédique de la Suisse Romande
2019-2020
Respiratory Clinical Trials
2016
Bronchiolitis Obliterans Syndrome (BOS), a fibrotic airway disease that may develop after lung transplantation, conventionally relies on pulmonary function tests (PFTs) for diagnosis due to limitations of CT imaging. Deep neural networks (DNNs) have not previously been used BOS detection. This study aims train DNN detect in scans using an approach tailored low-data scenarios. We trained co-training method designed enhance performance environments. Our employs auxiliary task makes the more...
Mental health disorders figure among the many comorbidities of obstructive respiratory diseases. The multisystemic characteristics chronic disease and its impact on quality life could affect depressive and/or anxiety disorders. We aimed to evaluate association spirometric indices, ventilatory disorders, self-reported diseases with psychiatric considering potential confounders.
Introduction Small airway dysfunction (SAD) may be an early sign of cardiopulmonary overload due to small mucosal thickening or related the oxidative stress characteristic cardiovascular diseases. A high prevalence SAD coexisting with chronic heart failure associated increase in all-cause mortality. We analysed association between and cardiac conditions PneumoLaus study. Methods is based on Swiss general urban population cohort CoLaus|PsyCoLaus. was defined by maximal mid-expiratory flow...
Lung transplant recipients (LTRs) are at increased risk for coronavirus disease 2019 (COVID-19)-associated complications.We aimed to describe the outcomes of polymerase chain reaction-documented severe acute respiratory syndrome 2 (SARS-CoV-2) infection in LTRs followed our institution from March 2020 July 2022. The primary outcome investigated was hospitalization or death COVID-19-related symptoms within 28 days diagnosis.Overall, 60 cases were included, which 18 (30%) reached outcome. Only...
This study investigated the effectiveness of stereotactic body radiotherapy with helical TomoTherapy (T-SBRT) for treating medically inoperable primary and second-primary early stage non-small-cell lung neoplasm (SPLN) evaluated whether movement organizing pneumonia (OP) within irradiation field (IF) can be detected via analysis radiological changes.Patients (n = 16) treated 1 year (2011-12) at our hospital by T-SBRT a total dose 60 Gy in five fractions were examined retrospectively. Outcome...
We assessed for the first time safety and efficacy of bronchoscopically inserted cs‐FM CyberKnife® SBRT delivery. show that this technique is safe resulted in a very high PPL tracking rate enabling optimal See Cover Image related Editorial
Stereotactic body radiotherapy (SBRT) is an effective method for the treatment of localized primary lung tumors. Cyberknife, a highly accurate SBRT technique, follows target during respiratory cycles using metallic fiducial marker (FM) previously inserted into lesion. Various methods have been described placement FM in peripheral pulmonary lesions; however, none these appropriate mediastinal or hilar The FMs central lesions to achieve particularly relevant due their higher mobility and...
Available data are limited concerning long-term lung function (LF) evolution after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in transplant (LT) recipients. The aim of this study is to determine the effect first SARS-CoV-2 on LF LT We analyzed spirometry results recipients followed at our institution (March 2020 July 2022) 3, 6, and 12 months infection. Overall, 42 patients cohort (70%) with COVID-19 were included for analysis. Forced expiratory volume 1 s (FEV1 )...
After basic immunization with 2 mRNA SARS-CoV-2 vaccine doses, only a small proportion of patients who are severely immunocompromised generate sufficient antibody response. Hence, we assessed the additional benefit third in different levels immunosuppression. In this observational extension COVERALL trial (Corona Vaccine Trial Platform), recruited from Swiss HIV Cohort Study and Transplant (ie, lung kidney transplant recipients). We collected blood samples before 8 weeks after vaccination...
Rationale and Objectives Computed tomography (CT) lung nodule assessment is routinely performed appears very promising for cancer screening. However, the radiation exposure through time remains a concern. With overall goal of an optimal management indeterminate nodules, objective this prospective study was therefore to evaluate potential optimized ultra-short echo (UTE) MRI detection volumetric assessment. Materials Methods Eight (54.9 ± 13.2 years) patients with at least 1 non-calcified ≥4...
To compare three different radiotherapy devices able to perform pulmonary stereotactic radiotherapy: CyberKnife® (CK), Helical Tomotherapy® (HT), and volumetric modulated arc therapy (VMAT). This study aims define the patients' outcome in terms of SBRT efficacy toxicities depending device choice.We retrospectively analyzed clinical, radiological, dosimetric data patients treated with lung between 2016 2020 at Lausanne University Hospital, using Chi2 test for proportions, t-test means...
Local recurrence after lung SBRT for early stage NSCLC is rare but its treatment remains a challenge due to limited surgical options. We report case series of 5 patients treated by stereotactic salvage reirradiation local relapse previous SBRT.Included presented an isolated primary within at least the 50% isodose treatment. Typical schedule was 60 Gy in 8 fractions 80% and delivered Cyberknife® using Synchrony® fiducial tracking system. Dose summations were performed evaluate safety...
Objective: The aim of this study is to characterize chest CT findings neutropenic patients with proven/probable invasive pulmonary aspergillosis (IPA). Methods: Hematological cancer admitted our institution (2007–2017) were retrospectively enrolled if the diagnostic criteria IPA during neutropenia met (EORTC/MSG). Galactomannan (GM) was routinely measured in serum and CT-scan performed case recurrent/persistent fever. Bronchoscopy abnormalities. Chest GM dosage analyzed at time suspicion....
Abstract Bronchiolitis Obliterans Syndrome (BOS), a fibrotic airway disease following lung transplantation, conventionally relies on pulmonary function tests (PFTs) for diagnosis due to limitations of CT images. Thus far, deep neural networks (DNNs) have not been used BOS detection. We optimized DNN detection solely using scans by integrating an innovative co-training method enhanced performance in low-data scenarios. The novel auxiliary task is predict the temporal precedence patients....
Acute fibrinous and organizing pneumonia (AFOP) is a severe form of acute lung injury which can occur after transplantation. Treatment empiric, based on immunosuppressive regimens the mortality rate very high. We report case young transplant (LT) recipient who developed AFOP following respiratory viral infection while suboptimal maintenance immunosuppression due to adherence issues. Diagnosis was confirmed by cryobiopsies showing intra-alveolar fibrin balls. Despite high dose systemic...
Background Recent evidence identified exposure to particulate matter of size ≤2.5 µm (PM 2.5 ) as a risk factor for high prevalence small airway dysfunction (SAD). We assessed the SAD in European region with low air pollution levels. Methods was defined maximum mid-expiratory flow (MMEF) <65% predicted value (PV) or MMEF <lower limit normal (LLN) measured by spirometry Swiss PneumoLaus cohort. performed bivariate and multivariable analysis criteria, age, sex, body mass index,...