A5039299406- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Vascular Procedures and Complications
- Cardiac Imaging and Diagnostics
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Renal and Vascular Pathologies
- Peripheral Artery Disease Management
- Extracellular vesicles in disease
- Inflammation biomarkers and pathways
- Colorectal Cancer Screening and Detection
- Circular RNAs in diseases
- Homelessness and Social Issues
- Traumatic Brain Injury Research
- Lung Cancer Research Studies
- Platelet Disorders and Treatments
- Animal Behavior and Reproduction
- Advanced X-ray and CT Imaging
- Mathematics Education and Programs
- Mathematics Education and Teaching Techniques
- Metal complexes synthesis and properties
- Cognitive and developmental aspects of mathematical skills
- S100 Proteins and Annexins
- Lymphoma Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
University of Toronto
2008-2024
Unity Health Toronto
2023
St. Michael's Hospital
2014-2022
Dalhousie University
2019
University of Rome Tor Vergata
2010-2013
Istituti di Ricovero e Cura a Carattere Scientifico
2012
European University of Rome
2011
Fondazione IRCCS Istituto Nazionale dei Tumori
1988
Prostate cancers show a slow progression from local lesion (primary tumor) to metastatic and hormone-resistant phenotype. After an initial step of hyperplasia, in high percentage cases neoplastic transformation event occurs that, less frequently, is followed by epithelial mesenchymal transition invasion healthy tissues (usually bones). MicroRNA-203 (miR-203) tumor suppressor microRNA often silenced different malignancies. Here, we that miR-203 downregulated clinical primary prostatic tumors...
MicroRNAs are tiny non-coding small endogenous RNAs that regulate gene expression by translational repression, mRNA cleavage and inhibition. The aim of this study was to investigate the hypermethylation miR-34b/c miR-148a in colorectal cancer, correlate data clinicopathological features. We also aimed evaluate faeces specimens as a novel non-invasive faecal-DNA-based screening marker.The 5-aza-2'-deoxycytidine treatment methylation-specific PCR were carried out detect miR-148a.The found...
Journal Article Activity of a Monoclonal Antibody-Saporin-6 Conjugate Against B-Lymphoma Cells Get access Marco Bregni, Bregni 3C. Gandini Bone Marrow Transplantation Unit, Division Medical Oncology, Istituto Nazionale TumoriVia Venezian 1, 20133 Milan, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Douglas A. Lappi, Lappi 4Laboratory Molecular Biology, Farmitalia-Carlo ErbaViale Bezzi 24, Milan Salvatore Siena, Siena Anna Formosa, Formosa Silvia Villa,...
Saliva's ability to mirror the internal physiological environment of an organism coupled with its facile accessibility makes it attractive diagnostic medium. The finding microRNAs (miRNAs) in saliva has expanded field biomarker discovery since these tiny non-coding RNAs affect various processes and diseases. Few reports have linked miRNAs tooth development eruption, none having studied this humans. As a first initiative describe whose modulations may reflect developing erupting teeth, we...
The COVID-19 pandemic has created an urgency to study the host gene response that leads variable clinical presentations of disease, particularly critical illness response. miRNAs have been implicated in mechanism immune dysregulation and thus hold potential as biomarkers and/or therapeutic agents with application. Hence, further analyses their altered expression is warranted. An important basis for this identifying appropriate reference genes high quality analysis studies. In current report,...
Abstract Background: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. However, prevention possible by early detection. In present work, we have demonstrated and validated a novel quantitative method based on DNA integrity assay mutation in faeces CRC patients using denaturing high performance liquid chromatography (dHPLC). Methods: Faecal (fDNA) was isolated from 28 CRC, 96 healthy 61 with adenomas. Adenomatosis polyposis coli (APC)-Long-DNA its mutations were...
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Fazit Vor einer Reihe komplexer vaskulärer Eingriffe ist die Untersuchung mittels CCTA mit etwa um den Faktor 5 – 10 geringeren KM-Mengen möglich, ohne dass Bildqualität darunter leidet, fassen Autoren zusammen. Einschränkend gilt allerdings, keine Aussagen über das tatsächliche Auftreten KM-Nephropathie möglich waren, zu deren Vermeidung ja erfolgt war. Weiterhin fand im Hinblick auf diagnostische Aussagekraft der Aufnahmen und benötigte kein direkter Vergleich zwischen konventioneller...