A5035513527- Neuroinflammation and Neurodegeneration Mechanisms
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Viral Infections and Outbreaks Research
- Infectious Encephalopathies and Encephalitis
- Inflammasome and immune disorders
- Ion channel regulation and function
- GABA and Rice Research
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Autism Spectrum Disorder Research
- Caveolin-1 and cellular processes
- Genetics, Aging, and Longevity in Model Organisms
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Cell Adhesion Molecules Research
- Environmental DNA in Biodiversity Studies
- Diet and metabolism studies
- Mitochondrial Function and Pathology
Rutgers, The State University of New Jersey
2022-2025
Rutgers Sexual and Reproductive Health and Rights
2024
Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence activity astrocytes poorly understood. Receptor interacting protein kinase-3 (RIPK3) signaling has recently been described as key regulator neuroinflammation, but whether this kinase mediates astrocytic responsiveness to neuronal death not yet studied. Here, we used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model Parkinson's disease show that RIPK3 drives...
Abstract Background Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection the central nervous system has been linked to a variety clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease adults. However, potential for influence brain physiology host behavior following apparently mild or subclinical less well understood. Furthermore, though deficits cognitive function are well-documented after recovery from neuroinvasive viral...
Abstract Potassium (K + ) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K channel KCNB1 (Kv2.1) neocortical development. Neuronal migration glutamatergic neurons was impaired neocortices null mice. Migratory defects persisted into adult brains, along with disrupted morphology synaptic connectivity. Mice developed seizure phenotype,...
Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In setting of neuroinvasive flavivirus infection, neurons employ immunologic kinase receptor-interacting 3 (RIPK3) to promote an antiviral transcriptional program, independently traditional function this enzyme promoting necroptotic death. However, while recent work has established roles for neuronal RIPK3 controlling mosquito-borne infections,...
Summary While recent work has identified roles for immune mediators in the regulation of neural activity, capacity cell intrinsic innate signaling within neurons to influence neurotransmission remains poorly understood. However, existing evidence linking with neuronal function suggests that modulation may serve previously undefined host protection during infection central nervous system. Here, we identify a specialized RIPK3, kinase traditionally associated necroptotic death, preserving...
Abstract Flaviviruses pose a significant threat to public health due their ability infect the central nervous system (CNS) and cause severe neurologic disease. Astrocytes play crucial role in pathogenesis of flavivirus encephalitis through maintenance blood-brain barrier (BBB) integrity modulation immune cell recruitment activation within CNS. We have previously shown that receptor interacting protein kinase-3 (RIPK3) is coordinator neuroinflammation during CNS viral infection, function...
Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In setting of neuroinvasive flavivirus infection, neurons employ immunologic kinase receptor-interacting 3 (RIPK3) to promote an antiviral transcriptional program, independently traditional function this enzyme promoting necroptotic death. However, while recent work has established roles for neuronal RIPK3 controlling mosquito-borne infections,...