A5103127112- Sarcoma Diagnosis and Treatment
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
Universidade Federal do Rio Grande do Norte
2022
Universidade Federal do Rio Grande
2022
University of Southern California
2022
Uterine leiomyosarcoma (uLMS) are rare and malignant tumors that arise in the myometrium cells whose diagnosis is based on histopathological features. Identifying diagnostic biomarkers for uLMS a challenge due to molecular heterogeneity scarcity of samples. In vivo vitro models urgently needed. Knockout female mice catalytic subunit immunoproteasome PSMB9 (MIM:177045) develop spontaneous uLMS. This study aimed analyze role tumorigenesis patient outcome.Molecular data from 3 non-related...
Abstract Uterine leiomyosarcoma (uLMS) is a rare and aggressive malignant tumor with poor prognosis. In contrast, uterine leiomyoma (uLM) the most common benign of uterus found in women reproductive age. Extracellular matrix (ECM) accumulation remodeling are thought to be crucial for development these two tumors. To better understand differences ECM dynamics tumors, we have collected samples from 67 uLMS, 66 uLM 68 normal myometrium (MM) which were analyzed by RNAseq (Illumina)...
Abstract The expression, abundance, and microarchitecture of fibrillar collagens are associated with tumor development aggressiveness in various carcinomas. However, the impact on mesenchymal tumors is less understood. While uterine leiomyomas, also known as fibroids, characterized by high collagen deposition depend ECM signaling for cell proliferation, malignant leiomyosarcomas has not been explored. Thus, identifying malignancy aggressiveness-associated features collagen-leiomyosarcoma...