A5070767630- Cellular Mechanics and Interactions
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Silicon Carbide Semiconductor Technologies
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Immune Cell Function and Interaction
- TGF-β signaling in diseases
- Nanowire Synthesis and Applications
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Uterine Myomas and Treatments
- Hippo pathway signaling and YAP/TAZ
Karolinska Institutet
2022-2024
University of Oxford
2023
Svenska Örtmedicinska Institute
2022
Successful translation of chimeric antigen receptor (CAR) T cell therapy for the treatment solid tumors has proved to be troublesome, mainly due complex tumor microenvironment promoting dysfunction and heterogeneity. Mesothelin (MSLN) emerged as an attractive target CAR several malignancies, including ovarian cancer. To improve clinical response rates with MSLN-CAR cells, a better understanding mechanisms impacting functionality in vitro is crucial. Here, we demonstrated superior cytolytic...
Fibrillar collagen deposition, stiffness and downstream signalling support the development of leiomyomas (LMs), common benign mesenchymal tumours uterus, are associated with aggressiveness in multiple carcinomas. Compared epithelial carcinomas, however, impact fibrillar collagens on malignant tumours, including uterine leiomyosarcoma (uLMS), remains elusive. In this study, we analyse network morphology density combined gene expression within uLMS, LM normal myometrium (MM). We find that,...
Despite the considerable progress in acute myeloid leukemia (AML) treatment, relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is still frequent and associated with a poor prognosis. Relapse has been shown to be correlated an incomplete eradication of CD34+ leukemic cells prior HSCT. Previously, we have that novel CD34-directed, bispecific T-cell engager (BTE) can efficiently redirect effector function toward cancer cells, thus eliminating vitro vivo. However, its...
Abstract The expression, abundance, and microarchitecture of fibrillar collagens are associated with tumor development aggressiveness in various carcinomas. However, the impact on mesenchymal tumors is less understood. While uterine leiomyomas, also known as fibroids, characterized by high collagen deposition depend ECM signaling for cell proliferation, malignant leiomyosarcomas has not been explored. Thus, identifying malignancy aggressiveness-associated features collagen-leiomyosarcoma...
Abstract Fibrillar collagen deposition, stiffness, and downstream signalling support the development of leiomyomas (LM), common benign mesenchymal tumours uterus, are associated with aggressiveness in multiple carcinomas. Compared to epithelial carcinomas, however, impact fibrillar collagens on malignant tumours, including uterine leiomyosarcoma (LMS), remains elusive. In this study, we analyse network morphology density combined gene expression LMS, LM normal myometrium (MM). We find that,...
Abstract Lipids play a major role in inflammatory diseases by altering cell functions, through their use as energy substrates or lipid mediators such oxylipins. Autophagy, lysosomal degradation pathway that limits inflammation, is known to impact on availability, however whether this controls inflammation remains unexplored. We found upon intestinal visceral adipocytes upregulate autophagy and adipocyte-specific loss of the gene Atg7 exacerbates inflammation. While decreased lipolytic...