A5059767036- Cholinesterase and Neurodegenerative Diseases
- Biochemical effects in animals
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Alzheimer's disease research and treatments
- Chemotherapy-induced organ toxicity mitigation
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Enzyme-mediated dye degradation
- Trace Elements in Health
- Coenzyme Q10 studies and effects
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Membrane Separation Technologies
- Plant tissue culture and regeneration
- Acute Lymphoblastic Leukemia research
- Private Equity and Venture Capital
- Drug Transport and Resistance Mechanisms
- Dialysis and Renal Disease Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Organophosphorus compounds synthesis
- Nanoparticles: synthesis and applications
- Transgenic Plants and Applications
- Histone Deacetylase Inhibitors Research
Tanta University
2020-2025
Kobe University
2020-2021
Breast cancer therapy options are limited due to its late diagnosis and poor prognosis. Doxorubicin is the fundamental approach for this disease. Because chemotherapy has numerous adverse effects, scope of existing research was appraise synergetic effect doxorubicin naringin explore underlying mechanism. The cytotoxicity on MCF-7 monitored. Furthermore, expression STAT3 JAK1 as well apoptotic metastatic related genes (Bax, Bcl-2, Survivin, VEGF) were conducted by immunoblotting assay...
Abstract Besides COVID‐19, two of the most critical outbreaks our day are insulin resistance, type 2 diabetes mellitus (T2DM), and Alzheimer's disease (AD). Each disease's pathophysiology is well established. Furthermore, a substantial overlap between them has coexisted. Uncertainty remains on whether T2DM AD parallel illnesses with same origin or separate linked through violent pathways. The current study was aimed at testing resistance in brain results symptoms not. Insulin induced brains...
In this study, the impact of chitosan (CS) and maitake (GF) nanoparticles towards renal toxicity induced by Ehrlich ascites carcinoma (EAC) in vivo model was conducted. Besides benchmark negative control group, EAC constructed intraperitoneal injection (i.p.) 2.5 × 10
Researchers are encountering challenges in addressing the issue of cancer cells becoming unresponsive to various chemotherapy treatments due drug resistance. This study was designed influence antioxidant resveratrol (RSV) sensitize resistant breast (BC) toward tamoxifen (TAM). The cytotoxic effects RSV and TAM against TAM-resistant LCC2 their parental michigan foundation-7 BC were determined by sulphorhodamine B assay. Further, expression levels multidrug resistance (MDR) genes including...
This study aims to investigate the interactions between osthole extracted from Egyptian citrus fruits as HDACs inhibitor by theoretical and practically. Besides, was assed anti-cancer activity. In this study, fruit characterized. The role of in vitro estimated evaluated antitumor activity against human lung cancer cells (A549), Caspase-9 detected. results obtained GC-MS indicate that grapefruit showed highest concentration compared other fruits. Moreover, competitively inhibits HDACs....
Abstract The reaction of (1,3‐diphenyl‐1H‐pyrazole‐4‐carbaldehyde) with different aromatic amines and triethylphosphite in the presence magnesium perchlorate as a catalyst resulted high yields new α‐aminophosphonates containing pyrazole moiety. structures newly prepared were confirmed using IR, elemental analysis, 1 H NMR, 13 C NMR spectra. antibacterial analysis compounds showed potential inhibitory effects against selected bacterial strains minimal concentrations (MIC) ranging from 12.5 to...
Introduction: Plant-mediated synthesis of silver nanoparticles (AgNPs) is accounted as an ecofriendly process. The present study was conducted to estimate the potency biogenic AgNPs against Ehrlich ascites carcinoma (EAC) cells in vitro and EAC-bearing mice vivo.
 Methods: were prepared using mango leaves extract characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission microscopy (TEM). mouse model established intraperitoneal injection 1 x 106 EAC...
A significant issue in cancer biology is finding anticancer therapies that effectively kill cells. Through the use of several aldehydes, Schiff bases based on branched poly (p-hydroxy styrene) are created. The polymer first chloroacetylated, then aminated with 1,4-phenylenediamine, and finally, aldehydes reacted to produce base compounds. utilization FTIR, TGA, XRD, NMR, elemental analysis, all synthesized Schiff-bases identified characterized. Further, antineoplastic potential evaluated...
The current study demonstrates the efficacy of Aspergillus niger (A. niger) in green synthesis iron oxide nanoparticles (IONPs). A. filtrate was employed as a biogenic source for IONP production. Characterization synthesized IONPs using ultraviolet -Visible spectroscopy revealed characteristic absorption peak around 320 nm, confirming nanoparticle formation. Fourier-transform infrared (FTIR) analysis identified presence fungal biomolecules, such proteins and carbohydrates, on surface,...
Background: The primary goal of researchers interested in the field oncology continues to be development a new anti-cancer medicine with minimal side effects. Due their toxicity and impressive performance, natural source-mediated treatments are attracting lot attention. Objective: purpose current work was extract purify resveratrol from local Leguminosae, such as peanut, beans, cowpea, lupine, fava bean, soybean, then assess its cyclooxygenase- 2 (COX-2) inhibition. aim evaluate anticancer...
Chemotherapeutic drugs for cancer treatment cause several side effects.Natural-derived constituents as anticancer agents are effective against various types.This study addressed the synergistic effect of co-treatment with avenanthramides (AVNS) and cisplatin (Cis) in Ehrlich ascites carcinoma-bearing mice.Seventy mice were divided into seven groups (n = 10) follows: Gp1 was used a negative control, from Gp2 to Gp7 inoculated 1 × 10 6 EAC-cells/mouse, then left EAC-bearing mice, Gp3 injected...
Among seven homologs of cytochrome b561 in a model organism C. elegans, Cecytb-2 was confirmed to be expressed digestive organs and considered as homolog human Dcytb functioning ferric reductase. protein Pichia pastoris cells, purified, reconstituted into phospholipid bilayer nanodisc. The nanodisc environments extremely stable more reducible with ascorbate than detergent-micelle state. We the reductase activity by analyzing oxidation ferrous heme upon addition substrate under anaerobic...
Amis: Alzheimer’s disease (AD) is one of the most rapidly growing diseases in recent times. Despite extensive research to find an appropriate medicine, there has been no effective drug until now.
 Study Design: The present study was designated investigate therapeutic impact antihyperglycemic dimethyl biguanide on symptoms.
 Methodology: induced male rats by AlCl3 and D-galactose at doses 50 120 mg/kg daily for month. Then, next four weeks, were given oral (200 daily).
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