A5101770293- Hair Growth and Disorders
- Dermatologic Treatments and Research
- Dyeing and Modifying Textile Fibers
- melanin and skin pigmentation
- Healthcare and Venom Research
- Wound Healing and Treatments
- Cancer and Skin Lesions
- Food Quality and Safety Studies
- Wnt/β-catenin signaling in development and cancer
- Skin Protection and Aging
- Magnolia and Illicium research
- Mast cells and histamine
- Ecology and Conservation Studies
- Polyamine Metabolism and Applications
- Pharmacological Effects of Natural Compounds
- Nerve injury and regeneration
- Vitamin C and Antioxidants Research
- Seaweed-derived Bioactive Compounds
- Dietary Effects on Health
- Growth Hormone and Insulin-like Growth Factors
- RNA regulation and disease
- Adipokines, Inflammation, and Metabolic Diseases
- Shoulder Injury and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Contact Dermatitis and Allergies
Jeju National University
2013-2024
Good Moonhwa Hospital
2019
Institute of Medical Sciences
2016
Seoul National University
2012
This study was conducted to evaluate the effect of Ecklonia cava, a marine alga native Jeju Island in Korea, on promotion hair growth. When vibrissa follicles were cultured presence E. cava enzymatic extract (which contains more than 35% dieckol) for 21 days, increased hair-fiber length. In addition, after topical application 0.5% onto back C57BL/6 mice, anagen progression hair-shaft induced. The treatment with resulted proliferation immortalized dermal papilla cells (DPC). Especially,...
In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased hair-fiber lengths. also accelerated anagen initiation in vivo. Moreover, found that was able to open KATP channel, which may contribute decreased 5α-reductase activity markedly proliferation dermal papilla cells, a central regulator cycle. levels cell cycle...
The hair cycle (anagen, catagen, and telogen) is regulated by the interaction between mesenchymal cells epithelial in follicles. proliferation of dermal papilla (DPCs), mesenchymal-derived fibroblasts, has emerged as a target for regulation cycle. Here, we show that vanillic acid, phenolic acid from wheat bran, promotes DPCs via PI3K/Akt/Wnt/β-catenin dependent mechanism. Vanillic promoted DPCs, accompanied increased levels cell-cycle proteins cyclin D1, CDK6, Cdc2 p34. also phospho(ser473)-...
Various studies addressing the increasing problem of hair loss, using natural products with few side effects, have been conducted. 5-bromo-3,4-dihydroxybenzaldehyde (BDB) exhibited anti-inflammatory effects in mouse models atopic dermatitis and inhibited UVB-induced oxidative stress keratinocytes. Here, we investigated its stimulating effect underlying mechanism action on growth rat vibrissa follicles dermal papilla cells (DPCs), required for regulation cycle length. BDB increased length...
People with obesity maintain low levels of inflammation; therefore, their exposure to foreign antigens can trigger an excessive immune response.In people or allergic contact dermatitis (ACD), symptoms are exacerbated by a reduction in the number regulatory T cells (Tregs) and IL-10/TGF-β-modified macrophages (M2 macrophages) at inflammatory site.Benefits intermittent fasting (IF) have been demonstrated for many diseases; however, responses regulated CD4+T obese ACD animal models poorly...
Androgenetic alopecia (AGA) is the most common type of hair loss, and characterized by transformation terminal scalp into vellus hair. The epidemiology AGA not fully understood. A strong genetic basis has long been identified, although little known its nongenetic causes.To evaluate association with a number environmental factors, including smoking, drinking sleeping habit.In total, 3114 Korean individuals who attended any one 17 dermatology clinics in 6 cities South Korea between March 2011...
This study was conducted to evaluate the promoting effect of Ishige sinicola, an alga native Jeju Island, Korea, on hair growth. When vibrissa follicles were cultured in presence I. sinicola extract for 21 days, increased hair-fiber length. After topical application onto back C57BL/6 mice, anagen progression shaft induced. The significantly inhibited activity 5α-reductase. Treatment immortalized dermal papilla cells (DPCs) with resulted increase cell proliferation, which accompanied by...
We investigated the neuritogenic effects of Tremella fuciformis (TF), which has been valued in traditional Chinese medicine as a remedy with nutritive and tonic actions, on PC12h cells. The cognitive improving TF scopolamine-induced (2 mg/kg, s.c.) amnesia rats were also evaluated using Morris water maze task by performing choline acetyltransferase (ChAT) immunohistochemistry. extract (0.01-1 microg/ml) promoted neurite outgrowth cells dose dependent manner. was highly efficient at...
Hair growth is regulated by the interaction between dermal papilla cells (DPC) and other inside hair follicle. Here, we show effect action mechanism of mackerel-derived fermented fish oil (FFO) extract its component docosahexaenoic acid (DHA) in control growth. The FFO was evaluated culture method vibrissa follicles vivo dotmatrix planimetry method. increased length hair-fibers enabled stimulated initiation into anagen phase cycle. As expected, significantly DPC proliferation. induced...
This study was conducted to evaluate the effects of Sargassum muticum extract and apo-9′-fucoxanthinone, a principal component S. muticum, on hair growth. When rat vibrissa follicles were treated with for 21 d, hair-fiber lengths increased significantly. Treatment EtOAc fraction markedly proliferation dermal papilla cells (DPCs) decreased 5α-reductase activity. In addition, significantly promoted anagen initiation in C57BL/6 mice. Especially, an active constituent from extract, caused...
This study was conducted to evaluate the effect of Schisandra nigra, a plant native Jeju Island, South Korea, on promotion hair growth. When rat vibrissa follicles were treated with 85% ethanol (EtOH) extract S. hair-fiber lengths increased significantly. In addition, after topical application EtOH nigra onto back C57BL/6 mice every other day, anagen progression shaft induced. Moreover, both expression proliferating cell nuclear antigen (PCNA) in bulb matrix region and proliferation...
This study was conducted to evaluate the effect of Crinum asiaticum, a plant native Jeju Island, Korea, on promotion hair growth. When rat vibrissa follicles were treated with 95% ethanol (EtOH) extract C. hair-fiber lengths increased significantly. In addition, after daily topical application EtOH asiaticum onto back C57BL/6 mice, anagen progression shaft induced. Moreover, proliferation immortalized dermal papilla cells. in phase extract, immunohistochemical analysis revealed that found...
Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in hair cycle. Dermal papilla cells (DPCs) regulate cycle play important roles growth regeneration. Myristoleic acid (MA) increases Wnt reporter activity DPCs. However, action mechanisms MA on stimulation anagen signaling DPCs not known. In this study, we evaluated effects anagen-activating pathways significantly increased DPC proliferation stimulated G2/M phase, accompanied increasing cyclin A,...
Hair loss remains a significant problem that is difficult to treat; therefore, there need identify safe natural materials can help patients with hair loss. We evaluated the anagen activation effects of limonin, which abundant in immature citrus fruits. Limonin increased proliferation rat dermal papilla cells (rDPC) by changing levels cyclin D1 and p27, increasing number BrdU-positive cells. autophagy decreasing phosphorylated mammalian target rapamycin phospho-Raptor, ATG7 LC3B. also...
The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. interaction of dermal papilla cells (DPCs) keratinocytes regulates the cycle growth. Humanin was discovered in surviving brain patients with Alzheimer’s disease. HNG, a humanin analogue, activates cell growth, proliferation, progression, it protects from apoptosis. This study performed to investigate promoting effect action mechanisms HNG on significantly increased DPC proliferation. shaft elongation...
Regulatory T cells (Tregs) play a crucial role in inflammatory responses by regulating the activity of various immune cells. M2 macrophages induced IL-10 and TGF-β exhibit anti-inflammatory functions induce Treg differentiation. Although beneficial effects 3-bromo-4,5-dihydroxybenzaldehyde (BDB) on diseases have been widely reported, mechanisms, through which it alleviates allergic contact dermatitis (ACD) via Tregs macrophages, are not well understood. Therefore, this study aimed to explore...