A5017508557- Uterine Myomas and Treatments
- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Gynecological conditions and treatments
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Gene expression and cancer classification
- Reproductive Health and Contraception
- Hernia repair and management
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Male Reproductive Health Studies
- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Vascular Anomalies and Treatments
- BRCA gene mutations in cancer
- Otitis Media and Relapsing Polychondritis
- Breast Implant and Reconstruction
University of Coimbra
2018-2024
Hospitais da Universidade de Coimbra
2016-2022
Institute of Immunology
2022
Genomics (United Kingdom)
2022
Both obesity and gestational diabetes mellitus are increasing in prevalence, being a major health problem pregnancy with independent additive impact on obstetrics outcomes. It is recognized that inadequate weight gain an risk factor for pregnancy-related morbidity. The aim of this study was to evaluate the effect obstetric neonatal outcomes obese women diabetes. Retrospective multicenter assessed group divided into three categories: who gained below (<5 kg), within (5–9 kg) above (>9 2009...
ObjectiveTo describe conditions regarding hysterectomies during the past 15 years in Portugal.Study designNationwide retrospective study of women who underwent hysterectomy Portuguese public hospitals period between 2000 and 2014. Patient data hospital codes, geography, patient age, indications, operative techniques, associated procedures, complications, admission dates, discharge dates 30-day postoperative readmissions were extracted from national database with information all Portugal. For...
Objective Metformin can be regarded as a first-line treatment in gestational diabetes mellitus (GDM) due to its safety and effectiveness. However, proportion of women do not achieve adequate glycemic control with metformin alone. We aim identify predictors this poor response metformin. Design methods Retrospective multicentre cohort study GDM who started treatment. The assessed was divided into group plus insulin group. Biometric demographic characteristics, data, obstetric, neonatal...
In the management of early-stage breast cancer (BC), lymph nodes (LNs) are typically characterised using One-Step Nucleic Acid Amplification (OSNA) assay, a standard procedure for assessing subclinical metastasis in sentinel LNs (SLNs). The pivotal role coordinating immune response against BC is often overlooked. Our aim was to improve prognostic information provided by OSNA assay and explore immune-related gene signatures SLNs. expression an panel analysed SLNs from 32 patients with Luminal...
Establishing an accurate prognosis for women diagnosed with breast cancer (BC) is extremely challenging. Axillary lymph node (ALN) evaluation considered of major prognostic value. The one-step nucleic acid amplification (OSNA) assay currently used assessing axillary sentinel (SLN) status in BC. Additionally, total tumor load (TTL) may help predict further metastatic involvement beyond the SLN. value primary BC location remains controversial due to lack consensus on biological differences...
This report describes a rare case of isolated fallopian tube torsion (IFTT) in premenarchal 11-year-old girl. The patient presented with subacute abdominal pain, associated nausea and vomiting. Sonographic findings revealed left enlargement free intraperitoneal fluid. Doppler mapping was not unequivocal. During exploratory laparoscopy, large pelvic necrotic mass found to be twisted tube. After detorsion, salpingectomy performed the recovered promptly, showing no complications 3 months post...
Uterine leiomyomas are the most common benign gynecological tumors. Symptomatic represent a major cause of hospitalization, particularly those associated with abnormal uterine bleeding (AUB) and anemia. The aim this study was to identify predictors anemia in women hospitalized due evaluate its impact on treatment management clinical outcomes.Population-based retrospective for fibroids public hospitals mainland Portugal between 2010 2015. Data were extracted from national database Central...
The One Step Nucleic Acid Amplification (OSNA) is being adopted worldwide for sentinel lymph nodes (SLNs) staging in breast cancer (BC). As major disadvantage, OSNA precludes prognostic information based on structural evaluation of SLNs. Our aim to identify biomarkers related tumor-microenvironment interplay exploring gene expression data from the remaining lysate. This study included 32 patients with early stage hormone receptors-positive BC. Remaining lysates were prepared targeted...
The one‑step nucleic acid amplification (OSNA) assay is a molecular method used for detecting breast cancer (BC) metastasis in sentinel lymph nodes (SLNs). However, this has major disadvantage, since it prevents tissue structure analysis, while only one marker can be evaluated, namely cytokeratin 19 mRNA. aim of the present study was to evaluate whether an OSNA‑discarded sample could suitable gene expression analysis SLN microenvironment. remaining intermediate phase centrifuged homogenate...
Background and Objectives: Ovarian surgical ablation (OSA) in estrogen receptor-positive (ER+) breast cancer is usually performed to halt ovarian function premenopausal patients. Since alternative pharmacological therapy exists few studies have investigated why surgery still performed, we aimed analyze the reasons for use of OSA despite remaining controversy. Materials Methods: Premenopausal ER+ patients treated at a tertiary center (2005–2011) were selected, with germline mutations...
Abstract Background Lymph nodes (LNs) are the main doorway for tumor cell metastases from primary site and its evaluation is a major prognostic factor. The One Step Nucleic Acid Amplification (OSNA) being adopted worldwide sentinel-LNs (SLNs) staging in breast cancer (BC). SLNs´ OSNA lysate may be used gene expression studies, potentially ideal samples to search new markers related immune response. Using targeted approach, we aim identify transcriptomic patterns of SLNs response biomarkers...