A5003033078- Cancer Immunotherapy and Biomarkers
- Cleft Lip and Palate Research
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Reproductive System and Pregnancy
- Eosinophilic Esophagitis
- Immunotherapy and Immune Responses
- Sports Performance and Training
- Neuropeptides and Animal Physiology
- Chemokine receptors and signaling
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Drug-Induced Hepatotoxicity and Protection
- Advanced Biosensing Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Genomics and Diagnostics
- Craniofacial Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Preterm Birth and Chorioamnionitis
- Genetic factors in colorectal cancer
- Muscle metabolism and nutrition
- Ferroptosis and cancer prognosis
Universidade Estadual de Montes Claros
2024
University of Coimbra
2019-2024
Genomics (United Kingdom)
2022
: Introdução: A Síndrome do Túnel Carpo (STC) é uma neuropatia compressiva causada pela compressão nervo mediano no punho, com maior prevalência entre mulheres de 45 a 60 anos. O diagnóstico clínico complementado por eletroneuromiografia, e o tratamento inclui abordagens conservadoras, como fisioterapia corticosteroides, ou cirúrgicas em casos graves. Os tratamentos minimamente invasivos vêm ganhando destaque eficácia alívio dos sintomas recuperação funcional. Metodologia: Foi realizada...
Drug-induced liver injury (DILI) is an unpredictable and feared side effect of antituberculosis treatment (AT). The present study aimed to identify clinical genetic variables associated with susceptibility AT-associated hepatotoxicity in patients pulmonary tuberculosis treated a standard protocol. Of 233 enrolled, 90% prospectively, 103 developed injury: 37 mild 66 severe phenotype (DILI). All hepatitis had RUCAM score ≥4 all DILI ≥ 6. Eight variants six candidate genes were assessed. A...
Abstract Background Preterm birth (PTB) is one of the major causes neonatal morbidity and mortality worldwide. It commonly accepted that act giving final step in a proinflammatory signaling cascade, orchestrated by an intrauterine milieu coupled to hormonal cues. Consequently, inflammatory process plays pivotal role during pathogenesis human labor, both term preterm deliveries. The ability innate lymphoid cells (ILCs) as pro-inflammatory mediators arose interest study their normal...
Non-syndromic orofacial cleft (NSOC) is a complex phenotype, involving multiple genetic and environmental factors. Association studies exploring the susceptibility to this prevalent oral malformation show variability of results in different populations. Using candidate gene approach, we aimed verify role four single-nucleotide polymorphisms (SNPs) NSOC Portuguese patients.
In the management of early-stage breast cancer (BC), lymph nodes (LNs) are typically characterised using One-Step Nucleic Acid Amplification (OSNA) assay, a standard procedure for assessing subclinical metastasis in sentinel LNs (SLNs). The pivotal role coordinating immune response against BC is often overlooked. Our aim was to improve prognostic information provided by OSNA assay and explore immune-related gene signatures SLNs. expression an panel analysed SLNs from 32 patients with Luminal...
The One Step Nucleic Acid Amplification (OSNA) is being adopted worldwide for sentinel lymph nodes (SLNs) staging in breast cancer (BC). As major disadvantage, OSNA precludes prognostic information based on structural evaluation of SLNs. Our aim to identify biomarkers related tumor-microenvironment interplay exploring gene expression data from the remaining lysate. This study included 32 patients with early stage hormone receptors-positive BC. Remaining lysates were prepared targeted...
Abstract Background: Preterm labor (PTL) is one of the major causes neonatal morbidity and mortality worldwide. It commonly accepted that act giving birth final step in a proinflammatory signaling cascade, orchestrated by an intrauterine milieu coupled to hormonal cues. Consequently, inflammatory process plays pivotal role during pathogenesis human labor, both term preterm deliveries. The aim this work was analyze abilities innate lymphoid cells (ILCs), specifically ILC3 NCR- cells, as...
Abstract Introduction : Cardiotoxicity is one of the possible consequences treating Hodgkin's lymphoma. This assumes a very important role in patients outcomes since, increasingly, theyhave higher survival rate, better quality life and inherently longer survival. due to improvement treatment this pathology. Material methods: Clinical information was collected from 103 about their age at diagnosis, sex, cardiovascular risk factors, anthracycline dose which they were subjected use mediastinal...
Abstract Background Lymph nodes (LNs) are the main doorway for tumor cell metastases from primary site and its evaluation is a major prognostic factor. The One Step Nucleic Acid Amplification (OSNA) being adopted worldwide sentinel-LNs (SLNs) staging in breast cancer (BC). SLNs´ OSNA lysate may be used gene expression studies, potentially ideal samples to search new markers related immune response. Using targeted approach, we aim identify transcriptomic patterns of SLNs response biomarkers...