A5043619939- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Lipid Membrane Structure and Behavior
- Synthesis of Tetrazole Derivatives
- Single-cell and spatial transcriptomics
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Acute Kidney Injury Research
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Central Venous Catheters and Hemodialysis
- Nuclear Receptors and Signaling
- Muscle Physiology and Disorders
- MicroRNA in disease regulation
- Dialysis and Renal Disease Management
- Genetic Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Macrophage Migration Inhibitory Factor
University of Michigan
2024
The University of Texas Health Science Center at San Antonio
2019-2022
Asia University
2020
Allen Institute for Brain Science
2017-2018
Icahn School of Medicine at Mount Sinai
2017-2018
China Medical University
2011-2013
A brain network comprising the medial prefrontal cortex (mPFC) and amygdala plays important roles in developmentally regulated cognitive emotional processes. However, very little is known about maturation of mPFC-amygdala circuitry. We conducted anatomical tracing mPFC projections optogenetic interrogation their synaptic connections with neurons basolateral (BLA) at neonatal to adult developmental stages mice. Results indicate that mPFC-BLA exhibit delayed emergence relative other pathways...
Duchenne muscular dystrophy (DMD), the most common form of childhood dystrophy, is caused by mutations in dystrophin gene. In addition to debilitating muscle degeneration, patients display a range cognitive deficits thought result from loss normally expressed brain. While function tissue well characterized, its role brain still poorly understood. The highest expression mouse cerebellar Purkinje cells (PCs), where it colocalizes with GABA A receptor clusters. Using ex vivo...
In previous study, n-butylidenephthalide (BP), a natural compound from Angelica sinensis, has anti-glioblastoma multiform (GBM) cell effects. this we modified BP structure to increase anti-GBM The effects of one derivative BP, (Z)-N-(2-(dimethylamino)ethyl)-2-(3-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)phenoxy)acetamide (PCH4) were tested in vitro and vivo.MTT assay PI/Annexin V performed evaluate the PCH4. Nur77 expression translocation assayed by RT-PCR Western blot. siRNA was used...
Abstract Autism spectrum disorder (ASD) is characterized by a complex etiology, with genetic determinants significantly influencing its manifestation. Among these, the Scn2a gene emerges as pivotal player, crucially involved in both glial and neuronal functionality. This study elucidates underexplored roles of oligodendrocytes, subsequent impact on myelination auditory neural processes. The results reveal nuanced interplay between oligodendrocytes axons, where deletion causes alterations...
<title>Abstract</title> Autism spectrum disorder (ASD) is a neurodevelopmental characterized by complex sensory processing deficits. A key unresolved question how alterations in neural connectivity and communication translate into the behavioral manifestations seen ASD. Here, we investigate oligodendrocyte dysfunction alters myelin plasticity neuronal activity, leading to auditory associated with We focus on <italic>SCN2A</italic> gene, an ASD-risk factor, understand its role myelination...
Many synapses, including parallel fiber synapses in the cerebellum, express presynaptic GABA A receptors. However, reports of functional consequences receptor activation are variable across from inhibition to enhancement transmitter release. We find that function is bidirectional at depending on concentration and modulation receptors mice. Activation by low concentrations enhances glutamate release, whereas higher inhibits Furthermore, blocking B reduces currents shifts responses toward...
Abstract Many neurons, including cerebellar granule cells, exhibit a tonic GABA current mediated by extrasynaptic A receptors. This is critical regulator of firing and the target many clinically relevant compounds. Using combination patch clamp electrophysiology photolytic uncaging RuBi-GABA we show that B receptors are tonically active enhance receptor currents in cells. enhancement not associated with meaningful changes potency, mean channel open-time, open probability, or single-channel...
Background Genetic, environmental, immunological, and hormonal factors contribute to the etiology of Tourette syndrome (TS). From genetic standpoint, TS is a heterogeneous disorder. In our previous study, we found that single nucleotide polymorphism (SNP) x‐ray repair cross‐complementing group 1 ( XRCC1 ), DNA gene, was associated with TS. Previous studies also showed tyrosyl‐DNA phosphodiesterase (TDP1) interacts damaged DNA. However, relationship between SNPs TDP1 gene unknown. Therefore,...
Temporary vascular access (TVA) is frequently used during the first dialysis in patients with chronic kidney disease (CKD), and it associated an increased risk of infection, central vein stenosis, mortality. Here, factors TVA CKD were explored.This study included a single-center care program who initiated long-term renal replacement therapy. The primary outcome was use at dialysis. Factors possibly analyzed using Cox regression.Temporary 53.2% In total, 73.2% (n = 865) 26.8% 317) on...